Polymorphic Expression of UDP-Glucuronosyltransferase UGTlA Gene in Human Colorectal Cancer

  title={Polymorphic Expression of UDP-Glucuronosyltransferase UGTlA Gene in Human Colorectal Cancer},
  author={Min Wang and De-feng Sun and Shuai Ling Wang and Ying Qing and Shuo Chen and Dong Wu and Ying-min Lin and Ji-Zhuang Luo and Yan Qing Li},
  booktitle={PloS one},
BACKGROUND Polymorphism of genes encoding drug-metabolizing enzymes is known to play an important role in increased susceptibility of colorectal cancer. UGT1A gene locus has been suggested to define tissue-specific glucuronidation activity. Reduced capacity of glucuronidation is correlated with the development of colorectal cancer. Therefore, we sought to explore polymorphism of UGTlA gene in human colorectal cancer. METHODS Cancerous and healthy tissues were obtained from selectedpatients… CONTINUE READING


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