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Abnormalities in liver function are described in HIV-1-infected patients treated with atazanavir (ATV), an HIV-1 protease… Expand UDP-glucuronosyltransferase (UGT) is an enzyme that catalyses a major phase II reaction in drug metabolism. Glucuronidation… Expand Sunitinib (SUN) is a multi‐targeted tyrosine kinase inhibitor that was recently approved for the treatment of gastrointestinal… Expand PCDDs, PCDFs, and PCBs are persistent organic pollutants (POPs) that accumulate in animal products and may pose serious health… Expand Chemoresistance remains a major impediment in cancer therapy. Although major progress has been made in understanding the… Expand The aim of preclinical studies is to evaluate the safety and pharmacological effect of new drug entities through in vitro and in… Expand Resistance to chemotherapy is a major problem facing cancer treatment. Understanding the molecular basis for drug resistance has… Expand In humans, orally administered phenytoin, 5,5-diphenylhydantoin, is mainly excreted as 5-(4'-hydroxyphenyl)-5-phenylhydantoin (4… Expand BACKGROUND AND OBJECTIVE
The pathogenesis of the hyperbilirubinemia present in approximately 30% of neonates affected by glucose… Expand