U 0126

Known as: UO 126, U-0126, U126 cpd 
A synthetic organic compound that selectively inhibits the kinase activity of Mitogen-Activated Protein kinase, preventing cytokine and prostaglandin… (More)
National Institutes of Health

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Highly Cited
2008
Highly Cited
2008
Neuritic retraction represents a prominent feature of the degenerative phenotype associated with mutations in leucine rich repeat… (More)
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Highly Cited
2006
Highly Cited
2006
Although >66% of melanomas harbor activating mutations in BRAF and exhibit constitutive activity in the mitogen-activated protein… (More)
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Review
2006
Review
2006
Extracellular-signal-regulated kinase 5 (ERK5) is a member of the mitogen-activated protein kinase (MAPK) family and, similar to… (More)
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Highly Cited
2004
Highly Cited
2004
Adiponectin, an adipocyte-derived hormone, attenuates the production of TNFalpha by activated human macrophages. In the present… (More)
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Highly Cited
2003
Highly Cited
2003
Activating mutations in the BRAF kinase gene have recently been reported in human cancers. The aim of the present study was to… (More)
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Highly Cited
2003
Highly Cited
2003
Antimicrobial peptides produced by epithelial cells and neutrophils represent essential elements of innate immunity, and include… (More)
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Highly Cited
2002
Highly Cited
2002
Brain-derived neurotrophic factor (BDNF) is implicated in long-term synaptic plasticity in the adult hippocampus, but the… (More)
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Highly Cited
2000
Highly Cited
2000
The specificities of 28 commercially available compounds reported to be relatively selective inhibitors of particular serine… (More)
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Highly Cited
2000
Highly Cited
2000
Although much has been learned about the neurobiological mechanisms underlying Pavlovian fear conditioning at the systems and… (More)
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Highly Cited
1998
Highly Cited
1998
The compound U0126 (1,4-diamino-2,3-dicyano-1, 4-bis[2-aminophenylthio]butadiene) was identified as an inhibitor of AP-1… (More)
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