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U 0126

Known as: UO 126, U-0126, U126 cpd 
A synthetic organic compound that selectively inhibits the kinase activity of Mitogen-Activated Protein kinase, preventing cytokine and prostaglandin… 
National Institutes of Health

Related topics

Related topics

3 relations

Broader (3)

ButadienesEnzyme InhibitorsNitriles

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2009
Highly Cited
2009
Helminth Antigens Modulate Immune Responses in Cells from Multiple Sclerosis Patients through TLR2-Dependent Mechanisms1
To better understand the link between parasite infections and the course of multiple sclerosis (MS), we studied the role of TLRs… 
Highly Cited
2007
Highly Cited
2007
ERK2 but not ERK1 plays a key role in hepatocyte replication: An RNAi‐mediated ERK2 knockdown approach in wild‐type and ERK1 null hepatocytes
The mitogen‐activated protein kinases (MAPKs) ERK1 and ERK2 have been implicated in various physiological events, and specific… 
Highly Cited
2005
Highly Cited
2005
Redox control of angiogenic factors and CD31-positive vessel-like structures in mouse embryonic stem cells after direct current electrical field stimulation.
Highly Cited
2005
Highly Cited
2005
Cytoplasmic retention of peroxide‐activated ERK provides survival in primary cultures of rat hepatocytes
Reactive oxygen species (ROS) are implicated in tissue damage causing primary hepatic dysfunction following ischemia/reperfusion… 
Highly Cited
2003
Highly Cited
2003
Bombesin, Lysophosphatidic Acid, and Epidermal Growth Factor Rapidly Stimulate Focal Adhesion Kinase Phosphorylation at Ser-910
A rapid increase in the tyrosine phosphorylation of focal adhesion kinase (FAK) has been extensively documented in cells… 
Highly Cited
2003
Highly Cited
2003
Pituitary adenylate cyclase‐activating polypeptide prevents C2‐ceramide‐induced apoptosis of cerebellar granule cells
The sphingolipid metabolites, ceramides, are critical mediators of the cellular stress response and play an important role in the… 
Highly Cited
2003
Highly Cited
2003
Constitutively Active Gα16 Stimulates STAT3 via a c-Src/JAK- and ERK-dependent Mechanism*
The hematopoietic-specific Gα16 protein has recently been shown to mediate receptor-induced activation of the signal transducer… 
Highly Cited
2001
Highly Cited
2001
The polo-like kinase Plx1 is required for activation of the phosphatase Cdc25C and cyclin B-Cdc2 in Xenopus oocytes.
In the Xenopus oocyte system mitogen treatment triggers the G(2)/M transition by transiently inhibiting the cAMP-dependent… 
Highly Cited
2001
Highly Cited
2001
Persistent Activation of Nuclear Factor-&kgr;B by Interleukin-1&bgr; and Subsequent Inducible NO Synthase Expression Requires Extracellular Signal-Regulated Kinase
The role of extracellular signal-regulated kinase (ERK) was studied in the signaling pathway by which interleukin-1&bgr; (IL-1… 
Highly Cited
2001
Highly Cited
2001
Gram-Positive and Gram-Negative Bacteria Do Not Trigger Monocytic Cytokine Production through Similar Intracellular Pathways
ABSTRACT Toll-like receptors (TLRs) are involved in human monocyte activation by lipopolysaccharide (LPS) and Staphylococcus… 
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