Molecular mechanisms and regulation of opioid receptor signaling.
In the current review, recent advances in the delineation basis for the multiple opioid receptor signaling, and their regulation at multiple levels are examined.
Gz-mediated hormonal inhibition of cyclic AMP accumulation.
Mutationally activated alpha subunits of Gi2 (alpha i2) constitutively inhibit cAMP accumulation when transfected into cells and Gz can trigger an effector pathway in response to hormone receptors that ordinarily interact with PTX-sensitive Gi proteins.
Characterization and Channel Coupling of the P2Y12Nucleotide Receptor of Brain Capillary Endothelial Cells*
The presence in the brain capillary endothelial cell of the P2Y12 receptor is a significant extension of its functional range, and that action, like their cAMP response, was pertussis toxin-sensitive.
Regulation of Multiple Effectors by the Cloned δ‐Opioid Receptor: Stimulation of Phospholipase C and Type II Adenylyl Cyclase
Cotransfection studies revealed that the δ‐opioid receptor can utilize Gz to regulate cAMP accumulation and to stimulate the formation of inositol phosphates.
The cloned platelet thrombin receptor couples to at least two distinct effectors to stimulate phosphoinositide hydrolysis and inhibit adenylyl cyclase.
Melatonin mt1 and MT2 receptors stimulate c-Jun N-terminal kinase via pertussis toxin-sensitive and -insensitive G proteins.
Integration of Signals from Receptor Tyrosine Kinases and G Protein-Coupled Receptors
This review investigates recent advances that have been made in understanding the mechanisms of cross talk between GPCRs and RTKs, with a focus on GPCR-mediated activation of the Ras/MAPK pathway, GPCr-induced transactivation of RTks, G PCR- mediated activation of JNK, and p38 MAPK, integration of signals by RhoGTPases, and activation of G protein signaling pathways by RTKS.
The ORL1 Receptor: Molecular Pharmacology and Signalling Mechanisms
This review will attempt to summarize recent research by many groups that has revealed numerous subtleties of the ORL1 receptor and its signalling pathways, as well as document the efforts to produce high-affinity selective ligands for the ORl1 receptor that may be of value as research and therapeutic tools.
Cycloastragenol Is a Potent Telomerase Activator in Neuronal Cells: Implications for Depression Management
It is demonstrated that CAG stimulates telomerase activity and cell proliferation in human neonatal keratinocytes and rat neuronal cells, and induces CREB activation followed by tert and bcl2 expression, and may have a novel therapeutic role in depression.
Promoting axon regeneration in the adult CNS by modulation of the melanopsin/GPCR signaling
- Songshan Li, Chao Yang, Kai Liu
- BiologyProceedings of the National Academy of Sciences
- 1 February 2016
It is found that the light-responsive G protein-coupled receptor (GPCR) melanopsin could promote axonal regeneration after optic nerve crush by activating mTOR, and it is shown that light, Gq/11 signaling, and neuronal activity contribute to the mechanism that underlies this effect.