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cGMP-dependent protein kinase activates Ca-activated K channels in cerebral artery smooth muscle cells.
TLDR
It is demonstrated that NO and a membrane-permeable analogue of cGMP can activate KCa channels in on-cell patches approximately twofold and cG MP-PK, in the presence of ATP andcGMP added directly to the intracellular surface of inside-out patches, increases channel activity by approximately eightfold.
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Cardiomyocytes differentiated in vitro from embryonic stem cells developmentally express cardiac-specific genes and ionic currents.
TLDR
The data demonstrate that ES cell-derived cardiomyocytes represent a unique model to investigate the early cardiac development and permit pharmacological/toxicological studies in vitro.
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The GTP-binding protein, Go9 regulates neuronal calcium channels
TLDR
An inhibitory effect of the opioid D-Ala2, D-Leu5-enkephalin (DADLE) on the calcium current (ICa) in neuroblastoma x glioma hybrid cells (N x G cells) is reported and it is proposed that Go is involved in the functional coupling of opiate receptors to neuronal voltage-dependent calcium channels.
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Differentiation of pluripotent embryonic stem cells into the neuronal lineage in vitro gives rise to mature inhibitory and excitatory neurons
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Bone marrow–derived hematopoietic cells generate cardiomyocytes at a low frequency through cell fusion, but not transdifferentiation
TLDR
It is shown that unfractionated bone marrow cells and a purified population of hematopoietic stem and progenitor cells efficiently engraft within the infarcted myocardium, and that bone marrow–derived cardiomyocytes were observed outside the infarsia at a low frequency and were derived exclusively through cell fusion.
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Estimation of Action Potential Changes from Field Potential Recordings in Multicellular Mouse Cardiac Myocyte Cultures
TLDR
The characterization of the FP allows for the first time to estimate AP changes and the contribution of individual current components to the AP by the help of non-invasive recording within a multicellular cardiac preparation during long-term culture.
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Morphological, biochemical, and electrophysiological characterization of a clonal cell (H9c2) line from rat heart.
TLDR
In radioligand binding experiments, a specific, saturable, stereoselective and reversible high-affinity [3H]-(+)PN 200-110 binding with a dissociation constant Kd = 0.53 +/- 0.28 nM is identified, which is unlikely to be related to a Ca2+ channel protein.
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Comparison of the Ca2 +  currents induced by expression of three cloned α1 subunits, α1G, α1H and α1I, of low‐voltage‐activated T‐type Ca2 +  channels
TLDR
Comparing reactivation after long‐term inactivation was fastest for currents arising from expression of α1I and slowest in cells expressing α1H calcium channels, which may allow correlation of the α1G, α2 +  and α1i induced currents with their in vivo counterparts.
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Pluripotent mouse embryonic stem cells are able to differentiate into cardiomyocytes expressing chronotropic responses to adrenergic and cholinergic agents and Ca2+ channel blockers.
TLDR
Cardiomyocytes differentiating from pluripotent embryonic stem cells are able to develop adrenoceptor and cholinoceptors and signal transduction pathways as well as L-type Ca2+ channels as a consequence of cell-cell interactions during embryoid body formation in vitro, independent of the development in living organisms.
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Muscle cell differentiation of embryonic stem cells reflects myogenesis in vivo: developmentally regulated expression of myogenic determination genes and functional expression of ionic currents.
The mouse blastocyst-derived embryonic stem cell (ES cell) line BLC6 efficiently differentiates into myosin heavy chain-, desmin- and myogenin-positive skeletal muscle cells when cultivated in…
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