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Trioxsalen

Known as: 2',4,8-Trimethylpsoralen, Trioxysalen, Trioxysalene 
Pigmenting photosensitizing agent obtained from several plants, mainly Psoralea corylifolia. It is administered either topically or orally in… Expand
National Institutes of Health

Related topics

Related topics

24 relations

Narrower (6)

4,8-dimethyl-5'-carboxypsoralenTrisoralenaminomethyltrioxsalenhydroxymethyltrioxsalen
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AlbinismChildDisorders of Porphyrin MetabolismDrug Allergy
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Broader (2)

Photosensitizing AgentsTrimethylpsoralen

Papers overview

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Highly Cited
2000
Highly Cited
2000
Arrest of S-phase progression is impaired in Fanconi anemia cells.
Fanconi anemia (FA) is an inherited cancer-susceptibility disorder, characterized by genomic instability, hypersensitivity to DNA… Expand
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Highly Cited
1999
Highly Cited
1999
Trioxsalen bath PUVA did not increase the risk of squamous cell skin carcinoma and cutaneous malignant melanoma in a joint analysis of 944 Swedish and Finnish patients with psoriasis
It has been suggested that trioxsalen bath and ultraviolet (UV) A (PUVA) is associated with a very low or no risk of non‐melanoma… Expand
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Highly Cited
1996
Highly Cited
1996
Cancer incidence among Finnish patients with psoriasis treated with trioxsalen bath PUVA.
BACKGROUND Systemic methoxsalen PUVA increases nonmelanoma skin cancer risk in a dose-dependent manner, whereas trioxsalen bath… Expand
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1995
1995
A new psoralen‐containing gel for topical PUVA therapy: development, and treatment results in patients with palmoplantar and plaque‐type psoriasis, and hyperkeratotic eczema
Summary Topical photochemotherapy with psoralen and its derivatives 4.5′,8‐trimethylpsoralen (TMP) and 8‐methoxypsoralen (8‐MOP… Expand
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Highly Cited
1994
Highly Cited
1994
Trimethylpsoralen induces small deletion mutations in Caenorhabditis elegans.
To examine the mutagenic spectrum of 4,5',8-trimethylpsoralen (TMP) in Caenorhabditis elegans, we isolated mutations in the unc… Expand
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Review
1992
Review
1992
The evolution of photochemotherapy with psoralens and UVA (PUVA): 2000 BC to 1992 AD.
The therapeutic uses of naturally occurring psoralens in modern-day medicine (8-methoxypsoralen (8-MOP), 5-methoxypsoralen (5-MOP… Expand
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Highly Cited
1992
Highly Cited
1992
Comparison of the carcinogenic potential of trioxsalen bath PUVA and oral methoxsalen PUVA. A preliminary report.
BACKGROUND AND DESIGN There is an increasing concern about the long-term carcinogenic effect of oral psoralen with long-wave UV… Expand
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Highly Cited
1982
Highly Cited
1982
Psoralen-deoxyribonucleic acid photoreaction. Characterization of the monoaddition products from 8-methoxypsoralen and 4,5'8-trimethylpsoralen.
The isolation and structural characterization are described of the major monoaddition products formed in the photoreaction of two… Expand
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Highly Cited
1977
Highly Cited
1977
Synthesis and characterization of new psoralen derivatives with superior photoreactivity with DNA and RNA.
The synthesis of five new psoralen derivatives is described. Three of these, 4'-hydroxymethyl-4,5',8-trimethylpsoralen, 4… Expand
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Highly Cited
1976
Highly Cited
1976
Treatment of psoriasis with trioxsalen baths and dysprosium lamps.
Photochemotherapeutic treatment of psoriasis with trioxsalen baths (0.5 mg/1) for 15 minutes followed by irradiation with… Expand
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