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Pot1, the Putative Telomere End-Binding Protein in Fission Yeast and Humans
Telomere proteins from ciliated protozoa bind to the single-stranded G-rich DNA extensions at the ends of macronuclear chromosomes. We have now identified homologous proteins in fission yeast and inExpand
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The POT1–TPP1 telomere complex is a telomerase processivity factor
Telomeres were originally defined as chromosome caps that prevent the natural ends of linear chromosomes from undergoing deleterious degradation and fusion events. POT1 (protection of telomeres)Expand
  • 603
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Reverse transcriptase motifs in the catalytic subunit of telomerase.
Telomerase is a ribonucleoprotein enzyme essential for the replication of chromosome termini in most eukaryotes. Telomerase RNA components have been identified from many organisms, but no proteinExpand
  • 1,187
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Structure of human POT1 bound to telomeric single-stranded DNA provides a model for chromosome end-protection
The POT1 (protection of telomeres 1) protein binds the single-stranded overhang at the ends of chromosomes in diverse eukaryotes. It is essential for chromosome end-protection in the fission yeastExpand
  • 406
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Crystal Structure of a Group I Ribozyme Domain: Principles of RNA Packing
Group I self-splicing introns catalyze their own excision from precursor RNAs by way of a two-step transesterification reaction. The catalytic core of these ribozymes is formed by two structuralExpand
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Self-splicing RNA: Autoexcision and autocyclization of the ribosomal RNA intervening sequence of tetrahymena
In the macronuclear rRNA genes of Tetrahymena thermophila, a 413 bp intervening sequence (IVS) interrupts the 26S rRNA-coding region. A restriction fragment of the rDNA containing the IVS andExpand
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Self-splicing of group I introns.
  • T. Cech
  • Biology, Medicine
  • Annual review of biochemistry
  • 1990
PERSPECTlVES . ... . .... .. ..... ... . . ........ . .... ...... .... . ... 543 REACTION PATHWAY ... . . ... ...... . ....... .. ..... . ... . ..... .. . . ...... ... . . . 545 Splicing . . . . . .Expand
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Regulation of telomere length and function by a Myb-domain protein in fission yeast
Telomeres, the specialized nucleoprotein structures that comprise the ends of eukaryotic chromosomes1,2, are essential for complete replication3–5, and regulation of their length has been a focus ofExpand
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Saccharomyces cerevisiae telomerase is an Sm small nuclear ribonucleoprotein particle
Activation of the chromosome end-replicating enzyme telomerase can greatly extend the lifespan of normal human cells and is associated with most human cancers. In all eukaryotes examined, telomeraseExpand
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Conserved sequences and structures of group I introns: building an active site for RNA catalysis--a review.
  • T. Cech
  • Biology, Medicine
  • Gene
  • 20 December 1988
Group I introns fold to form an active site to mediate their own RNA splicing. Sequence elements conserved among the available set of 66 group I introns are compiled. Comparative sequence analysisExpand
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