• Publications
  • Influence
Pot1, the Putative Telomere End-Binding Protein in Fission Yeast and Humans
TLDR
It now appears that the protein that caps the ends of chromosomes is widely dispersed throughout the eukaryotic kingdom. Expand
The POT1–TPP1 telomere complex is a telomerase processivity factor
TLDR
The crystal structure of a domain of human TPP1 reveals an oligonucleotide/oligosaccharide-binding fold that is structurally similar to the β-subunit of the telomere end-binding protein of a ciliated protozoan, suggesting that TPP1 is the missing β- subunit of human POT1 protein. Expand
Reverse transcriptase motifs in the catalytic subunit of telomerase.
TLDR
The reverse transcriptase protein fold, previously known to be involved in retroviral replication and retrotransposition, is essential for normal chromosome telomere replication in diverse eukaryotes. Expand
Structure of human POT1 bound to telomeric single-stranded DNA provides a model for chromosome end-protection
TLDR
The crystal structure of the N-terminal half of human POT1 (hPOT1) protein bound to a telomeric single-stranded DNA (ssDNA) decamer, TTAGGGTTAG, is reported, providing an atomic-resolution model for chromosome end-capping. Expand
Crystal Structure of a Group I Ribozyme Domain: Principles of RNA Packing
TLDR
The structure indicates the extent of RNA packing required for the function of large ribozymes, the spliceosome, and the ribosome. Expand
Self-splicing RNA: Autoexcision and autocyclization of the ribosomal RNA intervening sequence of tetrahymena
TLDR
It is proposed that the IVS portion of the RNA has several enzyme-like properties that enable it to break and reform phosphodiester bonds and that enzymes, small nuclear RNAs and folding of the pre-rRNA into an RNP are unnecessary for these reactions. Expand
Self-splicing of group I introns.
  • T. Cech
  • Biology, Medicine
  • Annual review of biochemistry
  • 1990
TLDR
The Tetrahymena INTRON is described as a “spatially aggregating force” that “brings together the determinants of infectious disease and infectious disease in a synergistic manner”. Expand
Regulation of telomere length and function by a Myb-domain protein in fission yeast
TLDR
A genetic screen is used to identify a telomere protein in fission yeast, Tazlp (telomere-associated in Schizosaccharomyces pombe), that shares homology to the Myb proto-oncogene DNA-binding domain with hTRF, and may protect against activation of telomerase-independent pathways of telomeres elongation. Expand
Promiscuous RNA binding by Polycomb Repressive Complex 2
TLDR
These findings support a model in which PRC2's promiscuous binding to RNA transcripts allows it to scan for target genes that have escaped repression, thus leading to maintenance of the repressed state. Expand
Saccharomyces cerevisiae telomerase is an Sm small nuclear ribonucleoprotein particle
TLDR
It is shown that the Saccharomyces cerevisiae telomerase RNA has a 5′-2,2,7-trimethylguanosine (TMG) cap and a binding site for the Sm proteins, both hallmarks of small nuclear ribonucleoprotein particles (snRNPs) that are involved in nuclear messenger RNA splicing. Expand
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