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Trinucleotide Repeat Expansion

Known as: Repeats, Expanded Trinucleotide, Trinucleotide Repeats, Expanded, Repeat, Expanded Trinucleotide 
An increased number of contiguous trinucleotide repeats in the DNA sequence from one generation to the next. The presence of these regions is… 
National Institutes of Health

Related topics

Related topics

7 relations
Anticipation, GeneticChromosome Fragile SitesChromosome FragilityFragile X Syndrome

Papers overview

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Highly Cited
2010
Highly Cited
2010
Temporal ordering deficits in female CGG KI mice heterozygous for the fragile X premutation
2007
2007
The structure of Tap42/alpha4 reveals a tetratricopeptide repeat-like fold and provides insights into PP2A regulation.
Physiological functions of protein phosphatase 2A (PP2A) are determined via the association of its catalytic subunit (PP2Ac) with… 
Review
2006
Review
2006
Detection of induced male germline mutation: correlations and comparisons between traditional germline mutation assays, transgenic rodent assays and expanded simple tandem repeat instability assays.
Highly Cited
2001
Highly Cited
2001
Modification of indium tin oxide electrodes with repeat polynucleotides: electrochemical detection of trinucleotide repeat expansion.
Genomic expansion of the triplet repeat sequences 5'-(CTG)n and 5'-(CGG)n leads to myotonic dystrophy and fragile X syndrome… 
Review
2001
Review
2001
Microsatellite-containing genes from the channel catfish brain: evidence of trinucleotide repeat expansion in the coding region of nucleotide excision repair gene RAD23B.
Expansion of trinucleotide repeats within genes is well known to cause pathological conditions in humans. Here we report a large… 
Review
2001
Review
2001
Expansion of Trinucleotide Repeats
This review describes a novel type of genome instability, expansion of trinucleotide repeats. Originally discovered in 1991 upon… 
Highly Cited
2000
Highly Cited
2000
Stabilizing Effects of Interruptions on Trinucleotide Repeat Expansions in Saccharomyces cerevisiae
ABSTRACT In most trinucleotide repeat (TNR) diseases, the primary factor determining the likelihood of expansions is the length… 
Highly Cited
2000
Highly Cited
2000
Heptad-repeat regions of respiratory syncytial virus F1 protein form a six-membered coiled-coil complex.
The Respiratory Syncytial Virus (RSV) fusogenic glycoprotein F(1) was characterized using biochemical and biophysical techniques… 
Highly Cited
1996
Highly Cited
1996
Methylation of Expanded CCG Triplet Repeat DNA from Fragile X Syndrome Patients Enhances Nucleosome Exclusion*
Long tracts of CCG trinucleotide or CCGNN pentanucleotide repeats in DNA have previously been shown to resist assembly into… 
1996
1996
Characterization of large CTG repeat expansions in myotonic dystrophy alleles using PCR
The CTG trinucleotide repeat expansions that are associated with myotonic dystrophy can be up to several thousand repeat units in… 
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