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Chromosome Fragility

Known as: Chromosome Fragility [Disease/Finding], Chromosomal Fragility, Fragility, Chromosome 
Susceptibility of chromosomes to breakage leading to translocation; CHROMOSOME INVERSION; SEQUENCE DELETION; or other CHROMOSOME BREAKAGE related… 
National Institutes of Health

Related topics

Related topics

9 relations

Broader (1)

Chromosomal Instability
Chromosome BreakageChromosome Fragile SitesDNA Repeat ExpansionDNA Sequence, Unstable

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2017
Highly Cited
2017
Genome Organization Drives Chromosome Fragility
Review
2015
Review
2015
Fanconi anemia: a model disease for studies on human genetics and advanced therapeutics.
Review
2012
Review
2012
R loops: from transcription byproducts to threats to genome stability.
Highly Cited
2009
Highly Cited
2009
The FANC pathway and BLM collaborate during mitosis to prevent micro-nucleation and chromosome abnormalities
Loss-of-function of caretaker genes characterizes a group of cancer predisposition diseases that feature cellular… 
Highly Cited
2009
Highly Cited
2009
Replisome stalling and stabilization at CGG repeats, which are responsible for chromosomal fragility
Expanded CGG repeats cause chromosomal fragility and hereditary neurological disorders in humans. Replication forks stall at CGG… 
Review
2008
Review
2008
Human chromosome fragility.
Review
2007
Review
2007
Replication Fork Stalling at Natural Impediments
SUMMARY Accurate and complete replication of the genome in every cell division is a prerequisite of genomic stability. Thus, both… 
Review
2004
Review
2004
Telomere dysfunction in genome instability syndromes.
Highly Cited
2001
Highly Cited
2001
Negative Control of p53 by Sir2α Promotes Cell Survival under Stress
Highly Cited
1995
Highly Cited
1995
CGG repeats associated with DNA instability and chromosome fragility form structures that block DNA synthesis in vitro.
A large increase in the length of a CGG tandem array is associated with a number of triplet expansion diseases, including fragile… 
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