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Chromosome Fragility

Known as: Chromosome Fragility [Disease/Finding], Chromosomal Fragility, Fragility, Chromosome 
Susceptibility of chromosomes to breakage leading to translocation; CHROMOSOME INVERSION; SEQUENCE DELETION; or other CHROMOSOME BREAKAGE related… Expand
National Institutes of Health

Papers overview

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Highly Cited
2017
Highly Cited
2017
In this study, we show that evolutionarily conserved chromosome loop anchors bound by CCCTC-binding factor (CTCF) and cohesin are… Expand
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2015
2015
We have previously demonstrated that in Saccharomyces cerevisiae replication, checkpoint inactivation via a mec1 mutation leads… Expand
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Review
2012
Review
2012
RNA:DNA hybrid structures known as R loops were thought to be rare byproducts of transcription. In the last decade, however… Expand
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Highly Cited
2009
Highly Cited
2009
Specialized topoisomerases solve the topological constraints arising when replication forks encounter transcription. We have… Expand
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Highly Cited
2009
Highly Cited
2009
Loss-of-function of caretaker genes characterizes a group of cancer predisposition diseases that feature cellular… Expand
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Highly Cited
2009
Highly Cited
2009
Expanded CGG repeats cause chromosomal fragility and hereditary neurological disorders in humans. Replication forks stall at CGG… Expand
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Review
2008
Review
2008
Fragile sites are heritable specific chromosome loci that exhibit an increased frequency of gaps, poor staining, constrictions or… Expand
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Highly Cited
2007
Highly Cited
2007
Common fragile sites are regions of human chromosomes prone to breakage. Fragile site FRA16D spans the WWOX/FOR tumor suppressor… Expand
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Highly Cited
2001
Highly Cited
2001
Abstract The NAD-dependent histone deacetylation of Sir2 connects cellular metabolism with gene silencing as well as aging in… Expand
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Highly Cited
1995
Highly Cited
1995
A large increase in the length of a CGG tandem array is associated with a number of triplet expansion diseases, including fragile… Expand
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