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Chromosome Fragility

Known as: Chromosome Fragility [Disease/Finding], Chromosomal Fragility, Fragility, Chromosome 
Susceptibility of chromosomes to breakage leading to translocation; CHROMOSOME INVERSION; SEQUENCE DELETION; or other CHROMOSOME BREAKAGE related… Expand
National Institutes of Health

Related topics

Related topics

9 relations

Broader (1)

Chromosomal Instability
Chromosome BreakageChromosome Fragile SitesDNA Repeat ExpansionDNA Sequence, Unstable
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Papers overview

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Highly Cited
2017
Highly Cited
2017
Genome Organization Drives Chromosome Fragility
In this study, we show that evolutionarily conserved chromosome loop anchors bound by CCCTC-binding factor (CTCF) and cohesin are… Expand
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2015
2015
Break-seq reveals hydroxyurea-induced chromosome fragility as a result of unscheduled conflict between DNA replication and transcription.
We have previously demonstrated that in Saccharomyces cerevisiae replication, checkpoint inactivation via a mec1 mutation leads… Expand
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Review
2012
Review
2012
R loops: from transcription byproducts to threats to genome stability.
RNA:DNA hybrid structures known as R loops were thought to be rare byproducts of transcription. In the last decade, however… Expand
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Highly Cited
2009
Highly Cited
2009
Genome-Organizing Factors Top2 and Hmo1 Prevent Chromosome Fragility at Sites of S phase Transcription
Specialized topoisomerases solve the topological constraints arising when replication forks encounter transcription. We have… Expand
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Highly Cited
2009
Highly Cited
2009
The FANC pathway and BLM collaborate during mitosis to prevent micro-nucleation and chromosome abnormalities
Loss-of-function of caretaker genes characterizes a group of cancer predisposition diseases that feature cellular… Expand
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Highly Cited
2009
Highly Cited
2009
Replisome stalling and stabilization at CGG repeats, which are responsible for chromosomal fragility
Expanded CGG repeats cause chromosomal fragility and hereditary neurological disorders in humans. Replication forks stall at CGG… Expand
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Review
2008
Review
2008
Human chromosome fragility.
Fragile sites are heritable specific chromosome loci that exhibit an increased frequency of gaps, poor staining, constrictions or… Expand
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Highly Cited
2007
Highly Cited
2007
An AT-rich sequence in human common fragile site FRA16D causes fork stalling and chromosome breakage in S. cerevisiae.
Common fragile sites are regions of human chromosomes prone to breakage. Fragile site FRA16D spans the WWOX/FOR tumor suppressor… Expand
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Highly Cited
2001
Highly Cited
2001
Negative Control of p53 by Sir2α Promotes Cell Survival under Stress
Abstract The NAD-dependent histone deacetylation of Sir2 connects cellular metabolism with gene silencing as well as aging in… Expand
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Highly Cited
1995
Highly Cited
1995
CGG repeats associated with DNA instability and chromosome fragility form structures that block DNA synthesis in vitro.
A large increase in the length of a CGG tandem array is associated with a number of triplet expansion diseases, including fragile… Expand
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