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Sources, Fate, and Toxic Hazards of Oxygenated Polycyclic Aromatic Hydrocarbons (PAHs) at PAH- contaminated Sites
TLDR
Oxy-PAHs are important cocontaminants that should be taken into account during risk assessment and remediation of sites with high levels of PAHs, and should be included in monitoring programs at PAH-contaminated sites, even if a number of other toxicologically relevant compounds that may also be present are not monitored.
Oxygen-Insensitive Nitroreductases: Analysis of the Roles ofnfsA and nfsB in Development of Resistance to 5-Nitrofuran Derivatives in Escherichia coli
TLDR
It is shown that expression of plasmid-carried nFSA and nfsB genes in resistant mutants restores sensitivity to nitrofurans, and potential regional and sequence-specific determinants for insertion sequence element integration in nfsA and NfsB are discussed.
In vivo transgenic mutation assays.
Identification of Thyroid Hormone Receptor Binding Sites and Target Genes Using ChIP-on-Chip in Developing Mouse Cerebellum
TLDR
Findings provide mechanistic insight into impaired neurodevelopment resulting from TH deficiency and a rich bioinformatics resource for developing a better understanding of TR binding.
Cancer risk assessment of polycyclic aromatic hydrocarbon contaminated soils determined using bioassay-derived levels of benzo[a]pyrene equivalents.
TLDR
The results suggest that ELCR estimates for complex PAH mixtures determined using a targeted, chemical-specific approach are reasonable, albeit conservative, while Calculated risk estimates still depend on contentious PEFs and cancer slope factors.
Metabolism of Isovanillate, Vanillate, and Veratrate by Comamonas testosteroni Strain BR6020
TLDR
Studies using whole cells, cell extracts, and reverse transcriptase PCR showed that degradative activity and expression of vanA, ivaA, and ivaB are inducible, which suggests that the system mediating iVan uptake in whole cells does not mediate Ver uptake.
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