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Triapine

A synthetic heterocyclic carboxaldehyde thiosemicarbazone with potential antineoplastic activity. Triapine inhibits the enzyme ribonucleotide… 
National Institutes of Health

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Broader (1)

3-aminopyridine-2-carboxaldehyde thiosemicarbazone
DNA Synthesis InhibitionNCIt Antineoplastic Agent TerminologyRibonucleotide Reductase

Papers overview

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2016
2016
Cytotoxic activities, apoptotic induction and mitochondrial studies of selected cationic schiff bases from the thiosemicarbazone family / Saravana Kumar Sinniah
Thiosemicarbazone (TSC) is a Schiff base that has been receiving considerable attention owing to its promising biological… 
2014
2014
Development of novel Triapine derivatives to improve anticancer activity
Die antineoplastische Wirkung von α-N-heterocyclischen Thiosemicarbazonen ist schon seit den 1950er Jahren bekannt, wodurch sich… 
2014
2014
Triapine származékok réz(II)komplexeinek összehasonlító oldategyensúlyi vizsgálata
2013
2013
Kinetic studies on the oxidation of oxyhemoglobin by biologically active iron thiosemicarbazone complexes: relevance to iron-chelator-induced methemoglobinemia
The oxidation of oxyhemoglobin to methemoglobin has been found to be facilitated by low molecular weight iron(III… 
2011
2011
Induction and mechanism of growth arrest DNA damage-inducible gene 45 β in human hepatoma HepG2 cells by Triapine
Objective To identify the proximal promoter of down-expression of growth arrest DNA damage-inducible gene 45 β(GADD45β) and to… 
2011
2011
MANAGEMENT OF TRIAPINE-INDUCED METHEMOBLOBINEMIA: A CASE STUDY
2010
2010
A phase I study of prolonged infusion of triapine in combination with a fixed-dose rate of gemcitabine in patients with advanced solid tumors.
2602 Background: Triapine (T), an inhibitor of ribonucleotide reductase, enhances the activity of gemcitabine (G), and the… 
2009
2009
Effect of metal ion complexation on the antiproliferative activity of alpha-N-heterocyclic thiosemicarbazones
Die vorliegende Dissertation beschaftigt sich mit der Synthese neuartiger Metallkomplexe mit alpha-N-heterozyklischen… 
2007
2007
High incidence of symptomatic methemoglobinemia (metHb) in Asian patients (pts) treated with 3-Aminopyridine-2-carboxaldehyde thiosemicarbazone (3-AP, triapine) and gemcitabine (GEM) in a second-line…
18207 Background: Triapine (Vion Pharmaceuticals) is an inhibitor of ribonucleotide reductase that can enhance GEM uptake in GEM… 
2004
2004
Advances in Brief In Vitro Characterization of Enzymatic Properties and Inhibition of the p 53 R 2 Subunit of Human Ribonucleotide Reductase
p53R2 is a newly identified subunit of ribonucleotide reductase (RR) and plays a crucial role in supplying precursors for DNA… 
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