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Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition)
TLDR
There continues to be confusion regarding acceptable methods to measure autophagy, especially in multicellular eukaryotes, so it is important to update guidelines for monitoring autophagic activity in different organisms. Expand
Function and regulation of transferrin and ferritin.
TLDR
Iron represents a paradox for living systems by being essential for a wide variety of metabolic processes but also having the potential to cause deleterious effects, and a feedback control mechanism prevents the expansion of a catalytically active intracellular iron pool, while maintaining sufficient concentrations of the metal for metabolic needs. Expand
The molecular mechanisms of the metabolism and transport of iron in normal and neoplastic cells.
TLDR
Iron uptake by mammalian cells is mediated by the binding of serum Tf to the TfR, and recent work has suggested that the short-lived messenger molecule, NO, can affect cellular Fe metabolism via its interaction with IRP1. Expand
The Evolution of Iron Chelators for the Treatment of Iron Overload Disease and Cancer
TLDR
This review focuses on the evolution of iron chelators from initial lead compounds through to the development of novel chelating agents, many of which show great potential to be clinically applied in the treatment of iron overload disease and cancer. Expand
The potential of iron chelators of the pyridoxal isonicotinoyl hydrazone class as effective antiproliferative agents.
TLDR
Most of the PIH analogues were considerably more effective than DFO at both preventing 59Fe uptake from 59Fe-transferrin and in mobilizing 59Fe from prelabeled NB cells, and a linear relationship between Fe chelation efficacy and antiproliferative activity was found only for hydrazones derived from salicylaldehyde. Expand
Iron uptake and metabolism in the new millennium.
TLDR
The past decade has seen the identification of new molecules involved in iron metabolism, such as divalent metal transporter-1, ferroportin- 1, hepcidin, hemojuvelin and heme carrier protein-1 that remain unclear. Expand
A class of iron chelators with a wide spectrum of potent antitumor activity that overcomes resistance to chemotherapeutics
TLDR
Results indicate that the novel Fe chelators have potent and broad antitumor activity and can overcome resistance to established chemotherapeutics because of their unique mechanism of action. Expand
Mitochondrial iron trafficking and the integration of iron metabolism between the mitochondrion and cytosol
TLDR
This finding has revealed the ability of the mitochondrion to modulate whole-cell iron-processing to satisfy its own requirements for the crucial processes of heme and ISC synthesis. Expand
Cellular iron uptake, trafficking and metabolism: Key molecules and mechanisms and their roles in disease.
TLDR
Major aspects of the journey of iron from its initial cellular uptake, its modes of trafficking within cells, to an overview of its downstream utilization in the cytoplasm and within mitochondria are discussed. Expand
The role of iron in cell cycle progression and the proliferation of neoplastic cells.
TLDR
This review will focus on the molecular mechanisms induced following Fe chelation and the role of Fe in cell cycle progression. Expand
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