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Phosphate Adsorption Properties of Magnetite-Based Nanoparticles
Magnetite nanoparticles of 40 nm in size have been phosphated in orthophosphoric acid. Large phosphatation rates, equivalent to goethite capacity, have been pointed out, and the possibility ofExpand
Thiosemicarbazones from the old to new: iron chelators that are more than just ribonucleotide reductase inhibitors.
TLDR
Detailed investigations of the thiosemicarbazone group of ligands have demonstrated that they are highly effective chelators that, besides RR, also target a range of other molecules including NDRG1 and top2α, all of which contribute to their anticancer effects. Expand
2-Acetylpyridine thiosemicarbazones are potent iron chelators and antiproliferative agents: redox activity, iron complexation and characterization of their antitumor activity.
TLDR
This investigation generated the related 2-acetylpyridine thiosemicarbazone (HApT) analogues to examine the influence of the methyl group at the imine carbon and identified structural features necessary to form Fe complexes with potent anticancer activity. Expand
Iron chelators of the dipyridylketone thiosemicarbazone class: precomplexation and transmetalation effects on anticancer activity.
TLDR
The divalent Mn(II), Ni, Cu, and Zn(II) complexes of the HDpT analogues are equally active in preventing proliferation as their ligands, suggesting the complexes act as lipophilic vehicles facilitating intracellular delivery of the free ligand upon metal dissociation. Expand
Dipyridyl thiosemicarbazone chelators with potent and selective antitumor activity form iron complexes with redox activity.
TLDR
The most effective HDpT ligands as antiproliferative agents possess considerable lipophilicity and were shown to be charge neutral at physiological pH, allowing access to intracellular Fe pools. Expand
The NT-26 cytochrome c552 and its role in arsenite oxidation.
TLDR
The gene that encodes this protein downstream of the arsenite oxidase genes (aroBA) is identified, a cytochrome c(552), which is similar to a number of c-type cytochromes from the alpha-Proteobacteria and mitochondria and could also serve, in vitro, as an alternative electron acceptor for the arsenites oxidase. Expand
Insights into Structure and Function of the Active Site of SoxAX Cytochromes*
TLDR
Crystal structures of SoxAX with a heme ligand substitution (C236M) uncovered an inherent flexibility of this SoxA heme site, with both bonding distances and relative ligand orientation differing between asymmetric units and the new residue, Met236, representing an unusual rotamer of methionine. Expand
Novel thiosemicarbazones of the ApT and DpT series and their copper complexes: identification of pronounced redox activity and characterization of their antitumor activity.
TLDR
The structure-activity relationships described are important for the design of potent thiosemicarbazone Cu complexes and the importance of the inductive effects of substituents on the carbonyl group of the parent ketone, which influence the Cu(II/I) redox potentials because of their proximity to the metal center. Expand
Novel second-generation di-2-pyridylketone thiosemicarbazones show synergism with standard chemotherapeutics and demonstrate potent activity against lung cancer xenografts after oral and intravenous
TLDR
It was demonstrated by EPR spectroscopy that dimeric copper compounds of the type [CuLCl](2), identified crystallographically, dissociate in solution to give monomeric 1:1 Cu:ligand complexes, which represent the biologically active form of the complex. Expand
Copper redistribution in murine macrophages in response to Salmonella infection.
TLDR
It is proposed that copper hot spot formation contributes to antimicrobial responses against professional intracellular bacterial pathogens. Expand
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