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Ribonucleotide reductase (RNR) is the enzyme responsible for the conversion of ribonucleotides to 2'-deoxyribonucleotides and… Expand In eukaryotes, DNA damage elicits a multifaceted response that includes cell cycle arrest, transcriptional activation of DNA… Expand Thioredoxin, thioredoxin reductase and NADPH, the thioredoxin system, is ubiquitous from Archea to man. Thioredoxins, with a… Expand Ribonucleotide reductases provide the building blocks for DNA replication in all living cells. Three different classes of enzymes… Expand Resveratrol, a natural phytoalexin found in grapes, is well known for its presumed role in the prevention of heart disease… Expand Ribonucleotide reductase is the only enzyme that catalyses de novo formation of deoxyribo-nucleotides and is thus a key enzyme in… Expand It is generally accepted that DNA appeared after RNA during the chemical evolution of life. To synthesize DNA… Expand Ribonucleotide reductase has been demonstrated to be inhibited by NO synthase product(s). The experiments reported here show that… Expand The enzyme ribonucleotide reductase furnishes precursors for the DNA synthesis of all living cells. One of its constituents, the… Expand The complete (172,282 base pairs) nucleotide sequence of the B95-8 strain of Epstein–Barr virus has been established using the… Expand