Ribonucleotide Reductase

Known as: EC 1.17.4.-, Ribonucleotide Reductases [Chemical/Ingredient], Ribonucleotide Reductases 
Ribonucleotide Reductase is a heterodimeric cytoplasmic enzyme essential in dividing cells that reduces ribonucleotides to deoxyribonucleotide… (More)
National Institutes of Health

Related topics

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39 relations

Broader (2)

Alcohol OxidoreductasesIron-Sulfur Proteins
DNA ReplicationFludarabine phosphateGemcitabine ElaidateGemcitabine hydrochloride
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Narrower (10)

ICP10 protein, herpes simplex virus type 2NrdB protein, E coliNrdF protein, E coliNrdF protein, bacteria
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Papers overview

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Highly Cited
2007
Highly Cited
2007
Administration in non-human primates of escalating intravenous doses of targeted nanoparticles containing ribonucleotide reductase subunit M2 siRNA.
The results of administering escalating, i.v. doses of targeted nanoparticles containing a siRNA targeting the M2 subunit of… (More)
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Highly Cited
2003
Highly Cited
2003
Survival of DNA Damage in Yeast Directly Depends on Increased dNTP Levels Allowed by Relaxed Feedback Inhibition of Ribonucleotide Reductase
In eukaryotes, DNA damage elicits a multifaceted response that includes cell cycle arrest, transcriptional activation of DNA… (More)
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Highly Cited
2003
Highly Cited
2003
Cop9/signalosome subunits and Pcu4 regulate ribonucleotide reductase by both checkpoint-dependent and -independent mechanisms.
The signalosome is implicated in regulating cullin-dependent ubiquitin ligases. We find that two signalosome subunits, Csn1 and… (More)
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Review
2000
Review
2000
Physiological functions of thioredoxin and thioredoxin reductase.
Thioredoxin, thioredoxin reductase and NADPH, the thioredoxin system, is ubiquitous from Archea to man. Thioredoxins, with a… (More)
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Highly Cited
2000
Highly Cited
2000
A ribonucleotide reductase gene is a transcriptional target of p53 and p73
Many p53-inducible genes have been identified that might play a role in mediating the various downstream activities of p53. We… (More)
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Review
1998
Review
1998
Ribonucleotide reductases.
Ribonucleotide reductases provide the building blocks for DNA replication in all living cells. Three different classes of enzymes… (More)
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Highly Cited
1994
Highly Cited
1994
Structure of ribonucleotide reductase protein R1
Ribonucleotide reductase is the only enzyme that catalyses de novo formation of deoxyribo-nucleotides and is thus a key enzyme in… (More)
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Highly Cited
1994
Highly Cited
1994
Treatment of malignant gliomas using ganciclovir-hypersensitive, ribonucleotide reductase-deficient herpes simplex viral mutant.
We have demonstrated that attenuated mutants of herpes simplex virus (HSV) have therapeutic potential for malignant brain tumors… (More)
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Review
1992
Review
1992
Ribonucleotide reductase: regulation, regulation, regulation.
Ribonucleotide reductase (RNR) catalyses the rate limiting step in the production of deoxyribonucleotides needed for DNA… (More)
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Highly Cited
1991
Highly Cited
1991
Inhibition of tumor cell ribonucleotide reductase by macrophage-derived nitric oxide
Macrophage-derived nitric oxide (NO) is cytostatic to tumor cells and microbial pathogens. We tested whether one molecular target… (More)
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