Ribonucleotide Reductase

Known as: EC 1.17.4.-, Ribonucleotide Reductases [Chemical/Ingredient], Ribonucleotide Reductases 
Ribonucleotide Reductase is a heterodimeric cytoplasmic enzyme essential in dividing cells that reduces ribonucleotides to deoxyribonucleotide… (More)
National Institutes of Health

Papers overview

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Highly Cited
2007
Highly Cited
2007
The results of administering escalating, i.v. doses of targeted nanoparticles containing a siRNA targeting the M2 subunit of… (More)
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Highly Cited
2003
Highly Cited
2003
In eukaryotes, DNA damage elicits a multifaceted response that includes cell cycle arrest, transcriptional activation of DNA… (More)
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Highly Cited
2003
Highly Cited
2003
The signalosome is implicated in regulating cullin-dependent ubiquitin ligases. We find that two signalosome subunits, Csn1 and… (More)
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Review
2000
Review
2000
Thioredoxin, thioredoxin reductase and NADPH, the thioredoxin system, is ubiquitous from Archea to man. Thioredoxins, with a… (More)
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Highly Cited
2000
Highly Cited
2000
Many p53-inducible genes have been identified that might play a role in mediating the various downstream activities of p53. We… (More)
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Review
1998
Review
1998
Ribonucleotide reductases provide the building blocks for DNA replication in all living cells. Three different classes of enzymes… (More)
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Highly Cited
1994
Highly Cited
1994
Ribonucleotide reductase is the only enzyme that catalyses de novo formation of deoxyribo-nucleotides and is thus a key enzyme in… (More)
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Highly Cited
1994
Highly Cited
1994
We have demonstrated that attenuated mutants of herpes simplex virus (HSV) have therapeutic potential for malignant brain tumors… (More)
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Review
1992
Review
1992
Ribonucleotide reductase (RNR) catalyses the rate limiting step in the production of deoxyribonucleotides needed for DNA… (More)
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Highly Cited
1991
Highly Cited
1991
Macrophage-derived nitric oxide (NO) is cytostatic to tumor cells and microbial pathogens. We tested whether one molecular target… (More)
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