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Trapidil

Known as: (1,2,4)Triazolo(1,5-a)pyrimidin-7-amine, N,N-diethyl-5-methyl-, Trapidil [Chemical/Ingredient], Trapymin 
A coronary vasodilator agent.
National Institutes of Health

Related topics

Related topics

15 relations

Narrower (5)

AR 12456AR 12463AR 12465Rocornal
In Bloodagonistsanalogs & derivativesantagonists & inhibitors

Broader (3)

Phosphodiesterase InhibitorsPlatelet Aggregation InhibitorsVasodilator Agents

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2003
2003
Activation of Src kinase in platelet-derived growth factor-B-dependent tubular regeneration after acute ischemic renal injury.
2000
2000
Antiproliferative effects of trapidil in vascular smooth muscle cells are associated by inhibition of MAPK and P34(cdc2) activity.
Trapidil (Tra) is a potent coronary vasodilator. Recent studies have shown that Tra possesses antiproliferative activity in… 
1998
1998
Trapidil inhibits platelet-derived growth factor-stimulated mitogen-activated protein kinase cascade.
Trapidil, an antiplatelet drug, has been shown to reduce restenosis after angioplasty. It exerts its action, at least in part, by… 
1997
1997
The effects of the growth factor‐antagonist, trapidil, on remyelination in the CNS
In this study we describe the effects of trapidil, a putative platelet‐derived growth factor‐antagonist, on spontaneously… 
1990
1990
Pharmacological alteration of the lung vascular response to radiation.
Highly Cited
1986
Highly Cited
1986
Possible association of platelet-derived growth factor (PDGF) with the appearance of reactive astrocytes following brain injury in situ
1983
1983
Suppression of fibroblast proliferation in vitro and of myointimal hyperplasia in vivo by the triazolopyrimidine, Trapidil.
Platelet derived growth factor (PDGF) is a mitogen capable of stimulating the proliferation of both vascular smooth muscle cells… 
1982
1982
Evidence for "response to injury" hypothesis.
1981
1981
Prevention of cerebral ischemic symptoms in cerebral vasospasm with trapidil, an antagonist and selective synthesis inhibitor of thromboxane A2.
The results of our previous experimental and clinical studies led us to the hypothesis that, in the pathogenesis of cerebral… 
1974
1974
Quantitative and comparative studies of pharmacological features in the coronary, femoral and renal circulations with different coronary vasodilators.
Abstract Effects of various coronary vasodilators on the coronary, the femoral and the renal circulations were compared with… 
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