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Report of the Committee on the Classification and Diagnostic Criteria of Diabetes Mellitus
Diabetes mellitus is a group of diseases associated with various metabolic disorders, the main feature of which is chronic hyperglycemia due to insufficient insulin action. Its pathogenesis involvesExpand
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Calorie restriction enhances cell adaptation to hypoxia through Sirt1-dependent mitochondrial autophagy in mouse aged kidney.
Mitochondrial oxidative damage is a basic mechanism of aging, and multiple studies demonstrate that this process is attenuated by calorie restriction (CR). However, the molecular mechanism thatExpand
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Japanese Clinical Practice Guideline for Diabetes 2016
Diabetes 2016 Masakazu Haneda*, Mitsuhiko Noda, Hideki Origasa, Hiroshi Noto, Daisuke Yabe, Yukihiro Fujita, Atsushi Goto, Tatsuya Kondo, Eiichi Araki Asahikawa Medical University, Asahikawa, ,Expand
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Incretin release from gut is acutely enhanced by sugar but not by sweeteners in vivo.
Glucose-dependent insulinotropic polypeptide (GIP) and glucagon-like peptide-1 (GLP-1) are released during meals from endocrine cells located in the gut mucosa and stimulate insulin secretion fromExpand
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Structural and functional changes in the kidneys of high-fat diet-induced obese mice.
  • N. Deji, S. Kume, +9 authors T. Uzu
  • Biology, Medicine
  • American journal of physiology. Renal physiology
  • 2009
Metabolic syndrome has been reported to be associated with chronic kidney disease, but the mechanisms remain unclear. Although feeding of a high-fat diet (HFD) to C57BL/6 mice is reported to induceExpand
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Therapeutic efficacy of an angiotensin II receptor antagonist in patients with nonalcoholic steatohepatitis
The therapeutic efficacy of angiotensin II receptor antagonist, losartan, was studied in patients with nonalcoholic steatohepatitis (NASH). Seven patients with both NASH and hypertension were treatedExpand
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Translocation of glomerular p47phox and p67phox by protein kinase C-beta activation is required for oxidative stress in diabetic nephropathy.
Oxidative stress is implicated to play an important role in the development of diabetic vascular complications, including diabetic nephropathy. It is unclear whether oxidative stress is primarilyExpand
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Transcriptional Up-regulation of Inhibitory PAS Domain Protein Gene Expression by Hypoxia-inducible Factor 1 (HIF-1)
The inhibitory PAS (Per/Arnt/Sim) domain protein (IPAS), a dominant negative regulator of hypoxia-inducible transcription factors (HIFs), is potentially implicated in negative regulation ofExpand
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Effects of antioxidants in diabetes-induced oxidative stress in the glomeruli of diabetic rats.
Numerous reports have demonstrated that oxidative stress induced by diabetes plays an important role in the development and progression of diabetic vascular complications including nephropathy.Expand
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Role of altered renal lipid metabolism in the development of renal injury induced by a high-fat diet.
  • S. Kume, T. Uzu, +10 authors D. Koya
  • Biology, Medicine
  • Journal of the American Society of Nephrology…
  • 1 October 2007
Metabolic syndrome is associated with increased risk of chronic kidney disease, and the renal injury in patients with metabolic syndrome may be a result of altered renal lipid metabolism. We fedExpand
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