Trans-Activators

Known as: Transactivators, Trans Acting Factor, Trans Acting Factors 
Diffusible gene products that act on homologous or heterologous molecules of viral or cellular DNA to regulate the expression of proteins.
National Institutes of Health

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Papers overview

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Highly Cited
2007
Highly Cited
2007
Induced pluripotent stem cell lines derived from human somatic cells.
Somatic cell nuclear transfer allows trans-acting factors present in the mammalian oocyte to reprogram somatic cell nuclei to an… (More)
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Highly Cited
2005
Highly Cited
2005
microRNA-Directed Phasing during Trans-Acting siRNA Biogenesis in Plants
Plants and animals use small RNAs (microRNAs [miRNAs] and siRNAs) as guides for posttranscriptional and epigenetic regulation. In… (More)
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Highly Cited
2000
Highly Cited
2000
Statins as a newly recognized type of immunomodulator
Inhibitors of 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase, or statins, are effective lipid-lowering agents… (More)
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Highly Cited
1995
Highly Cited
1995
Transcriptional activation by tetracyclines in mammalian cells.
A transcriptional transactivator was developed that fuses the VP16 activation domain with a mutant Tet repressor from Escherichia… (More)
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Highly Cited
1992
Highly Cited
1992
Tight control of gene expression in mammalian cells by tetracycline-responsive promoters.
Control elements of the tetracycline-resistance operon encoded in Tn10 of Escherichia coli have been utilized to establish a… (More)
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Highly Cited
1989
Highly Cited
1989
The HIV-1 rev trans-activator acts through a structured target sequence to activate nuclear export of unspliced viral mRNA
HUMAN immunodeficiency virus type 1 (HIV-1) replication requires the expression of two classes of viral mRNA. The early class of… (More)
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Highly Cited
1988
Highly Cited
1988
Autonomous functional domains of chemically synthesized human immunodeficiency virus tat trans-activator protein.
HIV-1 encodes a potent trans-activator protein, tat, which is essential for viral gene expression. To study tat domains that… (More)
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Highly Cited
1988
Highly Cited
1988
Functional dissection of VP16, the trans-activator of herpes simplex virus immediate early gene expression.
Mature virions of herpes simplex virus type 1 contain an activating factor that primes transcription from the five virally… (More)
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Highly Cited
1987
Highly Cited
1987
Phorbol ester-inducible genes contain a common cis element recognized by a TPA-modulated trans-acting factor.
The promoter regions of several phorbol diester-(TPA-) inducible genes (collagenase, stromelysin, hMT IIA, and SV40) share a… (More)
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Highly Cited
1987
Highly Cited
1987
An inducible transcription factor activates expression of human immunodeficiency virus in T cells
Human immunodeficiency virus (HIV) production from latently infected T lymphocytes can be induced with compounds that activate… (More)
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