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Rev-independent expression of synthetic gag-pol genes of human immunodeficiency virus type 1 and simian immunodeficiency virus: implications for the safety of lentiviral vectors.
The safety of lentiviral vectors for clinical applications is still a major concern. The gag-pol expression plasmids and the lentiviral vectors used in previous studies contain homologous regions,Expand
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Polymorphic proteins encoded within BZLF1 of defective and standard Epstein-Barr viruses disrupt latency.
These experiments identify an Epstein-Barr virus-encoded gene product, called ZEBRA (BamHI fragment Z Epstein-Barr replication activator) protein, which activates a switch between the latent andExpand
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Characterization of Mycobacterium tuberculosis Complex DNAs from Egyptian Mummies by Spoligotyping
ABSTRACT Bone and soft tissue samples from 85 ancient Egyptian mummies were analyzed for the presence of ancient Mycobacterium tuberculosis complex DNA (aDNA) and further characterized byExpand
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Priming of strong, broad, and long-lived HIV type 1 p55gag-specific CD8+ cytotoxic T cells after administration of a virus-like particle vaccine in rhesus macaques.
Despite advances in the clinical management of HIV infection, using combinations of antiretroviral pharmaceuticals, a safe and efficacious vaccine is needed to limit the AIDS pandemic. It is nowExpand
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Molecular study on human tuberculosis in three geographically distinct and time delineated populations from ancient Egypt.
We describe the molecular identification of human tuberculosis (TB) from vertebral bone tissue samples from three different populations of ancient Egypt. The specimens were obtained from theExpand
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EB viral genomes in epithelial nasopharyngeal carcinoma cells.
PATIENTS with nasopharyngeal carcinomas regularly show high antibody titres directed against Epstein-Barr virus (EBV)-specific antigens1,2. The incidence of tumours is high in certain populations ofExpand
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First EBV vaccine trial in humans using recombinant vaccinia virus expressing the major membrane antigen.
In the absence of a truly representative animal model, the question of whether EBV-related diseases can be prevented by a vaccine has been studied for the first time in humans. A live recombinantExpand
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Real-Time Fluorescence PCR Assays for Detection and Characterization of Heat-Labile I and Heat-Stable I Enterotoxin Genes from Enterotoxigenic Escherichia coli
ABSTRACT To facilitate the diagnosis of enterotoxigenic Escherichia coli (ETEC) infections in humans, we developed and evaluated real-time fluorescence PCR assays for the Roche LightCycler (LC)Expand
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Molecular analysis of ancient microbial infections.
The detection of ancient microbial DNA offers a new approach for the study of infectious diseases, their occurrence, frequency and host-pathogen interaction in historic times and populations.Expand
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