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Controlling the elongation phase of transcription with P-TEFb.
Phylogenetic analyses of the components of the human elongation control machinery indicate that the number of mechanisms utilized to regulate P-TEFb function increased as organisms developed more complex developmental patterns. Expand
The Cyclin K/Cdk12 complex maintains genomic stability via regulation of expression of DNA damage response genes.
It is concluded that through regulation of expression of DNA damage response genes, CycK/Cdk12 protects cells from genomic instability and the essential role of Cyck for organisms in vivo is further supported. Expand
Human APOBEC3F Is Another Host Factor That Blocks Human Immunodeficiency Virus Type 1 Replication
- Yong-Hui Zheng, D. Irwin, T. Kurosu, K. Tokunaga, T. Sata, B. Peterlin
- Medicine, Biology
- Journal of Virology
- 1 June 2004
The human APOBEC3F protein is identified as another host factor that blocks human immunodeficiency virus type 1 (HIV-1) replication and induced G to A hypermutations in HIV genomic DNA, and the viral Vif protein counteracted its activity. Expand
Charting HIV's remarkable voyage through the cell: Basic science as a passport to future therapy
The dynamic interplay of host cell and virus is essential to the effort to eradicate HIV and this work helps us to understand this interplay in a more effective manner. Expand
Control of RNA initiation and elongation at the HIV-1 promoter.
The author reveals the mechanism of trans-activation by Tat in vivo and in vitro and the role of Cellular Factors that Interact with Tat. Expand
Flavopiridol Inhibits P-TEFb and Blocks HIV-1 Replication*
- Sheng Chao, K. Fujinaga, +5 authors D. Price
- Biology, Medicine
- The Journal of Biological Chemistry
- 15 September 2000
Flavopiridol found that the flavonoid potently inhibited transcription by RNA polymerase II in vitro by blocking the transition into productive elongation, a step controlled by P-TEFb. Expand
HIV Nef is Secreted in Exosomes and Triggers Apoptosis in Bystander CD4+ T Cells
It is found that Nef stimulates its own export via the release of exosomes from all cells examined, which facilitates the depletion of CD4+ T cells that is a hallmark of acquired immunodeficiency syndrome (AIDS). Expand
Dynamics of Human Immunodeficiency Virus Transcription: P-TEFb Phosphorylates RD and Dissociates Negative Effectors from the Transactivation Response Element
- K. Fujinaga, D. Irwin, Yehong Huang, R. Taube, T. Kurosu, B. Peterlin
- Biology, Medicine
- Molecular and Cellular Biology
- 15 January 2004
The transition from abortive to productive transcription and thus replication of HIV is defined and a mutant RD protein that mimics its phosphorylated form no longer binds TAR nor represses HIV transcription is defined. Expand
NF-kappaB binds P-TEFb to stimulate transcriptional elongation by RNA polymerase II.
NF-kappaB requires P-teFb to stimulate the elongation of transcription and P-TEFb plays an unexpected role in regulating apoptosis, and it is found that the activation of transcription by RelA also depends on P- TEFb. Expand
Interactions between HIV1 Nef and vacuolar ATPase facilitate the internalization of CD4.
The Nef binding protein 1 (NBP1) is identified, which interacts specifically with Nef in vitro and in vivo and helps to connect Nef with the endocytic pathway. Expand