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Tosylphenylalanyl Chloromethyl Ketone
Known as:
Chlorophenyltosylamidobutanone
, Chloromethyl Ketone, Tosylphenylalanyl
, Chloromethane, Tosylphenylalanyl
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An inhibitor of Serine Endopeptidases. Acts as alkylating agent and is known to interfere with the translation process.
National Institutes of Health
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Related topics
Related topics
11 relations
Broader (3)
Alkylating Agents
Protein Synthesis Inhibitors
Serine Proteinase Inhibitors
In Blood
agonists
analogs & derivatives
antagonists & inhibitors
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Narrower (1)
tyrosyl-valyl-alanyl-aspartic acid fluoromethyl ketone
Papers overview
Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2002
Highly Cited
2002
MCP-1 but not CINC synthesis is increased in rat pancreatic acini in response to cerulein hyperstimulation.
M. Bhatia
,
M. Brady
,
+5 authors
J. Slavin
American Journal of Physiology - Gastrointestinal…
2002
Corpus ID: 35375091
Inflammatory mediators including chemokines play a critical role in acute pancreatitis. The precise nature of early inflammatory…
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Highly Cited
2000
Highly Cited
2000
Serine protease inhibitors suppress cytochrome c-mediatedcaspase-9 activation and apoptosis during hypoxia-reoxygenation.
Z. Dong
,
P. Saikumar
,
Y. Patel
,
J. Weinberg
,
M. Venkatachalam
Biochemical Journal
2000
Corpus ID: 1653385
We have shown that reoxygenation of hypoxic rat kidney proximaltubule cells leads to apoptosis. This is mediated by translocation…
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Highly Cited
1996
Highly Cited
1996
Structural Change in α-Chymotrypsin Induced by Complexation with α1-Antichymotrypsin As Seen by Enhanced Sensitivity to Proteolysis†
E. Stavridi
,
K. O'Malley
,
+5 authors
B. Cooperman
1996
Corpus ID: 37558019
Both human neutrophil elastase (HNE) and free chymotrypsin (Chtr) proteolyze Chtr within the complex that Chtr forms with…
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Highly Cited
1993
Highly Cited
1993
Evidence that acrosin activity is important for the development of fusibility of mammalian spermatozoa with the oolemma: inhibitor studies using the golden hamster
H. Takano
,
R. Yanagimachi
,
U. A. Urch
Zygote (Cambridge. Print)
1993
Corpus ID: 33041043
Summary The sperm plasma membrane over the equatorial segment of the acrosome gains the ability to fuse with the oolemma some…
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Highly Cited
1982
Highly Cited
1982
Characterization of pro-opiocortin-converting activity in purified secretory granules from rat pituitary neurointermediate lobe.
Y. Loh
,
H. Gainer
Proceedings of the National Academy of Sciences…
1982
Corpus ID: 7898934
Lysates of secretory granules from rat pituitary neurointermediate lobes were incubated with [3H]arginine- or [3H]phenylalanine…
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Highly Cited
1980
Highly Cited
1980
A zinc metalloendopeptidase associated with dog pancreatic membranes.
R. Mumford
,
A. Strauss
,
J. Powers
,
P. Pierzchala
,
N. Nishino
,
M. Zimmerman
Journal of Biological Chemistry
1980
Corpus ID: 36661096
Assay of solubilized dog pancreas microsomes revealed the presence of an endopeptidase which hydrolyzed the fluorogenic peptide…
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Highly Cited
1979
Highly Cited
1979
Further evidence in support of a role for hamster sperm hydrolytic enzymes in the acrosome reaction.
C. W. Lui
,
S. Meizel
The Journal of experimental zoology
1979
Corpus ID: 6885237
The effects of trypsin inhibitors and phospholipase inhibitors on the acrosome reaction of washed cauda epididymal sperm of…
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Highly Cited
1976
Highly Cited
1976
Biochemical studies of proacrosin and acrosin from hamster cauda epididymal spermatozoa.
S. Meizel
,
S. Mukerji
Biology of Reproduction
1976
Corpus ID: 19557157
Partially purified proacrosin, the zymogen form of acrosin was obtained from unwashed hamster cauda epididymal spermatozoa by…
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Highly Cited
1976
Highly Cited
1976
Pregrowth hormone: product of the translation in vitro of messenger RNA coding for growth hormone.
P. M. Sussman
,
R. Tushinski
,
F. Bancroft
Proceedings of the National Academy of Sciences…
1976
Corpus ID: 5888429
Membrane fraction RNA isolated from rat pituitary tumor (GC) cells has been translated in a wheat germ extract. A product was…
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Highly Cited
1974
Highly Cited
1974
Increased protease levels in transformed cells: a casein overlay assay for the detection of plasminogen activator production.
Allan R. Goldberg
Cell
1974
Corpus ID: 42898338
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