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Tosylphenylalanyl Chloromethyl Ketone

Known as: Chlorophenyltosylamidobutanone, Chloromethyl Ketone, Tosylphenylalanyl, Chloromethane, Tosylphenylalanyl 
An inhibitor of Serine Endopeptidases. Acts as alkylating agent and is known to interfere with the translation process.
National Institutes of Health

Related topics

Related topics

11 relations

Broader (3)

Alkylating AgentsProtein Synthesis InhibitorsSerine Proteinase Inhibitors
In Bloodagonistsanalogs & derivativesantagonists & inhibitors

Narrower (1)

tyrosyl-valyl-alanyl-aspartic acid fluoromethyl ketone

Papers overview

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Highly Cited
2013
Highly Cited
2013
Deciphering the Diploid Ancestral Genome of the Mesohexaploid Brassica rapa[C][W]
This work reports on the reconstruction of the three diploid Brassica genomes with seven chromosomes involved in the origin of… 
Review
2011
Review
2011
Technology Integration Barriers: Urban School Mathematics Teachers Perspectives
Despite the promise of technology in education, many practicing teachers face several challenges when trying to effectively… 
Highly Cited
2009
Highly Cited
2009
Mathematics Teacher TPACK Standards and Development Model
What knowledge is needed to teach mathematics with digital technologies? The overarching construct, called technology, pedagogy… 
Review
2009
Review
2009
Learning about problem based learning: Student teachers integrating technology, pedagogy and content knowledge
What should constitute knowledge bases that we expect our future teachers to gain related to pedagogically sound technology… 
Review
2005
Review
2005
What Happens When Teachers Design Educational Technology? The Development of Technological Pedagogical Content Knowledge
We introduce Technological Pedagogical Content Knowledge (TPCK) as a way of representing what teachers need to know about… 
Highly Cited
1999
Highly Cited
1999
Angiotensin II induces interleukin-6 transcription in vascular smooth muscle cells through pleiotropic activation of nuclear factor-kappa B transcription factors.
Interleukin-6 (IL-6) is a multifunctional cytokine expressed by angiotensin II (Ang II)-stimulated vascular smooth muscle cells… 
Highly Cited
1996
Highly Cited
1996
Inhibition of NF‐kappaB/Rel induces apoptosis of murine B cells.
Apoptosis of the WEHI 231 immature B cell lymphoma line following membrane interaction with an antibody against the surface IgM… 
Highly Cited
1989
Highly Cited
1989
Yeast prohormone processing enzyme (KEX2 gene product) is a Ca2+-dependent serine protease.
The KEX2-encoded endoprotease was overproduced in yeast several hundred-fold and further purified to achieve a 10,000-fold… 
Highly Cited
1976
Highly Cited
1976
Binding of chloromethyl ketone substrate analogues to crystalline papain.
Papain (EC 3.4.22.2) is a proteolytic enzyme, the three-dimensional structure of which has been determined by x-ray diffraction… 
Highly Cited
1967
Highly Cited
1967
Research report
  • R. Acevedo
  • Revista odontologica de Puerto Rico
  • 1967
  • Corpus ID: 3083154
In this study, the proteolytic activity in the midgut of Ectomyelois ceratoniae as the major pest of pomegranate was investigated… 
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