Skip to search formSkip to main contentSkip to account menu

Tosylphenylalanyl Chloromethyl Ketone

Known as: Chlorophenyltosylamidobutanone, Chloromethyl Ketone, Tosylphenylalanyl, Chloromethane, Tosylphenylalanyl 
An inhibitor of Serine Endopeptidases. Acts as alkylating agent and is known to interfere with the translation process.
National Institutes of Health

Related topics

Related topics

11 relations

Broader (3)

Alkylating AgentsProtein Synthesis InhibitorsSerine Proteinase Inhibitors
In Bloodagonistsanalogs & derivativesantagonists & inhibitors

Narrower (1)

tyrosyl-valyl-alanyl-aspartic acid fluoromethyl ketone

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2002
Highly Cited
2002
MCP-1 but not CINC synthesis is increased in rat pancreatic acini in response to cerulein hyperstimulation.
Inflammatory mediators including chemokines play a critical role in acute pancreatitis. The precise nature of early inflammatory… 
Highly Cited
2000
Highly Cited
2000
Serine protease inhibitors suppress cytochrome c-mediatedcaspase-9 activation and apoptosis during hypoxia-reoxygenation.
We have shown that reoxygenation of hypoxic rat kidney proximaltubule cells leads to apoptosis. This is mediated by translocation… 
Highly Cited
1996
Highly Cited
1996
Structural Change in α-Chymotrypsin Induced by Complexation with α1-Antichymotrypsin As Seen by Enhanced Sensitivity to Proteolysis†
Both human neutrophil elastase (HNE) and free chymotrypsin (Chtr) proteolyze Chtr within the complex that Chtr forms with… 
Highly Cited
1993
Highly Cited
1993
Evidence that acrosin activity is important for the development of fusibility of mammalian spermatozoa with the oolemma: inhibitor studies using the golden hamster
Summary The sperm plasma membrane over the equatorial segment of the acrosome gains the ability to fuse with the oolemma some… 
Highly Cited
1982
Highly Cited
1982
Characterization of pro-opiocortin-converting activity in purified secretory granules from rat pituitary neurointermediate lobe.
Lysates of secretory granules from rat pituitary neurointermediate lobes were incubated with [3H]arginine- or [3H]phenylalanine… 
Highly Cited
1980
Highly Cited
1980
A zinc metalloendopeptidase associated with dog pancreatic membranes.
Assay of solubilized dog pancreas microsomes revealed the presence of an endopeptidase which hydrolyzed the fluorogenic peptide… 
Highly Cited
1979
Highly Cited
1979
Further evidence in support of a role for hamster sperm hydrolytic enzymes in the acrosome reaction.
The effects of trypsin inhibitors and phospholipase inhibitors on the acrosome reaction of washed cauda epididymal sperm of… 
Highly Cited
1976
Highly Cited
1976
Biochemical studies of proacrosin and acrosin from hamster cauda epididymal spermatozoa.
Partially purified proacrosin, the zymogen form of acrosin was obtained from unwashed hamster cauda epididymal spermatozoa by… 
Highly Cited
1976
Highly Cited
1976
Pregrowth hormone: product of the translation in vitro of messenger RNA coding for growth hormone.
Membrane fraction RNA isolated from rat pituitary tumor (GC) cells has been translated in a wheat germ extract. A product was… 
Highly Cited
1974
Highly Cited
1974
Increased protease levels in transformed cells: a casein overlay assay for the detection of plasminogen activator production.
By clicking accept or continuing to use the site, you agree to the terms outlined in our Privacy Policy (opens in a new tab), Terms of Service (opens in a new tab), and Dataset License (opens in a new tab)