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Tosylphenylalanyl Chloromethyl Ketone
Known as:
Chlorophenyltosylamidobutanone
, Chloromethyl Ketone, Tosylphenylalanyl
, Chloromethane, Tosylphenylalanyl
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An inhibitor of Serine Endopeptidases. Acts as alkylating agent and is known to interfere with the translation process.
National Institutes of Health
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Related topics
Related topics
11 relations
Broader (3)
Alkylating Agents
Protein Synthesis Inhibitors
Serine Proteinase Inhibitors
In Blood
agonists
analogs & derivatives
antagonists & inhibitors
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Narrower (1)
tyrosyl-valyl-alanyl-aspartic acid fluoromethyl ketone
Papers overview
Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2013
Highly Cited
2013
Deciphering the Diploid Ancestral Genome of the Mesohexaploid Brassica rapa[C][W]
Feng Cheng
,
T. Mandáková
,
Jian Wu
,
Q. Xie
,
M. Lysak
,
Xiaowu Wang
Plant Cell
2013
Corpus ID: 6180286
This work reports on the reconstruction of the three diploid Brassica genomes with seven chromosomes involved in the origin of…
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Review
2011
Review
2011
Technology Integration Barriers: Urban School Mathematics Teachers Perspectives
Patrick Wachira
,
Jared Keengwe
2011
Corpus ID: 30029869
Despite the promise of technology in education, many practicing teachers face several challenges when trying to effectively…
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Highly Cited
2009
Highly Cited
2009
Mathematics Teacher TPACK Standards and Development Model
M. Niess
,
Robert N. Ronau
,
+6 authors
G. Kersaint
2009
Corpus ID: 177990459
What knowledge is needed to teach mathematics with digital technologies? The overarching construct, called technology, pedagogy…
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Review
2009
Review
2009
Learning about problem based learning: Student teachers integrating technology, pedagogy and content knowledge
H. So
,
Bosung Kim
2009
Corpus ID: 14689069
What should constitute knowledge bases that we expect our future teachers to gain related to pedagogically sound technology…
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Review
2005
Review
2005
What Happens When Teachers Design Educational Technology? The Development of Technological Pedagogical Content Knowledge
Matthew J. Koehler
,
Punya Mishra
2005
Corpus ID: 61816983
We introduce Technological Pedagogical Content Knowledge (TPCK) as a way of representing what teachers need to know about…
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Highly Cited
1999
Highly Cited
1999
Angiotensin II induces interleukin-6 transcription in vascular smooth muscle cells through pleiotropic activation of nuclear factor-kappa B transcription factors.
Y. Han
,
M. Runge
,
A. Brasier
Circulation research
1999
Corpus ID: 9382606
Interleukin-6 (IL-6) is a multifunctional cytokine expressed by angiotensin II (Ang II)-stimulated vascular smooth muscle cells…
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Highly Cited
1996
Highly Cited
1996
Inhibition of NF‐kappaB/Rel induces apoptosis of murine B cells.
M. Wu
,
H. Lee
,
+7 authors
G. Sonenshein
The EMBO journal
1996
Corpus ID: 3120238
Apoptosis of the WEHI 231 immature B cell lymphoma line following membrane interaction with an antibody against the surface IgM…
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Highly Cited
1989
Highly Cited
1989
Yeast prohormone processing enzyme (KEX2 gene product) is a Ca2+-dependent serine protease.
R. Fuller
,
A. Brake
,
J. Thorner
Proceedings of the National Academy of Sciences…
1989
Corpus ID: 1479339
The KEX2-encoded endoprotease was overproduced in yeast several hundred-fold and further purified to achieve a 10,000-fold…
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Highly Cited
1976
Highly Cited
1976
Binding of chloromethyl ketone substrate analogues to crystalline papain.
J. Drenth
,
K. H. Kalk
,
H. Swen
Biochemistry
1976
Corpus ID: 35159166
Papain (EC 3.4.22.2) is a proteolytic enzyme, the three-dimensional structure of which has been determined by x-ray diffraction…
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Highly Cited
1967
Highly Cited
1967
Research report
R. Acevedo
Revista odontologica de Puerto Rico
1967
Corpus ID: 3083154
In this study, the proteolytic activity in the midgut of Ectomyelois ceratoniae as the major pest of pomegranate was investigated…
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