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Tosylphenylalanyl Chloromethyl Ketone

Known as: Chlorophenyltosylamidobutanone, Chloromethyl Ketone, Tosylphenylalanyl, Chloromethane, Tosylphenylalanyl 
An inhibitor of Serine Endopeptidases. Acts as alkylating agent and is known to interfere with the translation process.
National Institutes of Health

Related topics

Related topics

11 relations

Broader (3)

Alkylating AgentsProtein Synthesis InhibitorsSerine Proteinase Inhibitors
In Bloodagonistsanalogs & derivativesantagonists & inhibitors
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Narrower (1)

tyrosyl-valyl-alanyl-aspartic acid fluoromethyl ketone

Papers overview

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Highly Cited
2013
Highly Cited
2013
Deciphering the diploid ancestral genome of the Mesohexaploid Brassica rapa.
The genus Brassica includes several important agricultural and horticultural crops. Their current genome structures were shaped… Expand
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Highly Cited
2009
Highly Cited
2009
Mathematics teacher TPACK standards and development model
What knowledge is needed to teach mathematics with digital technologies? The overarching construct, called technology, pedagogy… Expand
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Highly Cited
2000
Highly Cited
2000
Apaf-1 oligomerizes into biologically active approximately 700-kDa and inactive approximately 1.4-MDa apoptosome complexes.
Apaf-1, by binding to and activating caspase-9, plays a critical role in apoptosis. Oligomerization of Apaf-1, in the presence of… Expand
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Highly Cited
1999
Highly Cited
1999
Angiotensin II induces interleukin-6 transcription in vascular smooth muscle cells through pleiotropic activation of nuclear factor-kappa B transcription factors.
Interleukin-6 (IL-6) is a multifunctional cytokine expressed by angiotensin II (Ang II)-stimulated vascular smooth muscle cells… Expand
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Highly Cited
1997
Highly Cited
1997
Internucleosomal DNA cleavage triggered by plasma membrane damage during necrotic cell death. Involvement of serine but not cysteine proteases.
Autolytic DNA breakdown, detected as smears in electrophoretic gels, is a late event in necrosis. On the other hand… Expand
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Highly Cited
1996
Highly Cited
1996
Inhibition of NF-kappaB/Rel induces apoptosis of murine B cells.
Apoptosis of the WEHI 231 immature B cell lymphoma line following membrane interaction with an antibody against the surface IgM… Expand
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Highly Cited
1995
Highly Cited
1995
Interleukin (IL)-10 inhibits nuclear factor kappa B (NF kappa B) activation in human monocytes. IL-10 and IL-4 suppress cytokine synthesis by different mechanisms.
Our previous studies in human monocytes have demonstrated that interleukin (IL)-10 inhibits lipopolysaccharide (LPS)-stimulated… Expand
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Highly Cited
1995
Highly Cited
1995
Identification of actin as a substrate of ICE and an ICE-like protease and involvement of an ICE-like protease but not ICE in VP-16-induced U937 apoptosis.
Human leukemia U937 cells are induced to undergo apoptosis by several chemotherapeutic agents; however, the cellular components… Expand
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Highly Cited
1989
Highly Cited
1989
Yeast prohormone processing enzyme (KEX2 gene product) is a Ca2+-dependent serine protease.
The KEX2-encoded endoprotease was overproduced in yeast several hundred-fold and further purified to achieve a 10,000-fold… Expand
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Highly Cited
1967
Highly Cited
1967
Research report
  • R Acevedo
  • Revista odontologica de Puerto Rico
  • 1967
    • Corpus ID: 3083154
In this study, the proteolytic activity in the midgut of Ectomyelois ceratoniae as the major pest of pomegranate was investigated… Expand
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