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Tosylphenylalanyl Chloromethyl Ketone

Known as: Chlorophenyltosylamidobutanone, Chloromethyl Ketone, Tosylphenylalanyl, Chloromethane, Tosylphenylalanyl 
An inhibitor of Serine Endopeptidases. Acts as alkylating agent and is known to interfere with the translation process.
National Institutes of Health

Related topics

Related topics

11 relations

Broader (3)

Alkylating AgentsProtein Synthesis InhibitorsSerine Proteinase Inhibitors
In Bloodagonistsanalogs & derivativesantagonists & inhibitors

Narrower (1)

tyrosyl-valyl-alanyl-aspartic acid fluoromethyl ketone

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
1995
Highly Cited
1995
Identification of actin as a substrate of ICE and an ICE-like protease and involvement of an ICE-like protease but not ICE in VP-16-induced U937 apoptosis.
Human leukemia U937 cells are induced to undergo apoptosis by several chemotherapeutic agents; however, the cellular components… 
Highly Cited
1986
Highly Cited
1986
Study of an octadecaneuropeptide derived from diazepam binding inhibitor (DBI): biological activity and presence in rat brain.
An endogenous brain neuropeptide with 104 amino acid residues that modulates gamma-aminobutyric acid receptor function was termed… 
Highly Cited
1986
Highly Cited
1986
Down regulation of phorbol diester receptors by proteolytic degradation of protein kinase C in a cultured cell line of fetal rat skin keratinocytes.
Highly Cited
1983
Highly Cited
1983
Plasmodium knowlesi: studies on invasion of rhesus erythrocytes by merozoites in the presence of protease inhibitors.
Highly Cited
1981
Highly Cited
1981
Secretion of proteins and glycoproteins by the rat epididymis: regional differences, androgen-dependence, and effects of protease inhibitors, procaine, and tunicamycin.
Protein synthesis and secretion by the epididymis was studied in vitro by incubating tissue pieces with radioactive amino acids… 
Highly Cited
1980
Highly Cited
1980
Studies on mechanism of action of anti-tumor-promoting agents: their specificity in two-stage promotion.
The effects of fluocinolone acetonide (FA), retinoic acid (RA), and tosylphenylalanine chloromethyl ketone (TPCK) on two-stage… 
Review
1977
Review
1977
Specificity of porcine pancreatic elastase, human leukocyte elastase and cathepsin G. Inhibition with peptide chloromethyl ketones.
Highly Cited
1977
Highly Cited
1977
Further characterization of intracellular precursor polyproteins of Rauscher leukemia virus.
Highly Cited
1977
Highly Cited
1977
Preparative purification of the rat mast cell chymase. Characterization and Interaction with granule components
The rat mast cell granule chymotrypsinlike enzyme was purified to homogeneity from 1 M NaCl solubilized membrane and granule-rich… 
Highly Cited
1974
Highly Cited
1974
Increased protease levels in transformed cells: a casein overlay assay for the detection of plasminogen activator production.
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