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Tosylphenylalanyl Chloromethyl Ketone

Known as: Chlorophenyltosylamidobutanone, Chloromethyl Ketone, Tosylphenylalanyl, Chloromethane, Tosylphenylalanyl 
An inhibitor of Serine Endopeptidases. Acts as alkylating agent and is known to interfere with the translation process.
National Institutes of Health

Related topics

Related topics

11 relations

Broader (3)

Alkylating AgentsProtein Synthesis InhibitorsSerine Proteinase Inhibitors
In Bloodagonistsanalogs & derivativesantagonists & inhibitors
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Narrower (1)

tyrosyl-valyl-alanyl-aspartic acid fluoromethyl ketone

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2013
Highly Cited
2013
Deciphering the Diploid Ancestral Genome of the Mesohexaploid Brassica rapa[C][W]
This work reports on the reconstruction of the three diploid Brassica genomes with seven chromosomes involved in the origin of… Expand
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Highly Cited
2009
Highly Cited
2009
Mathematics Teacher TPACK Standards and Development Model
What knowledge is needed to teach mathematics with digital technologies? The overarching construct, called technology, pedagogy… Expand
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Highly Cited
2009
Highly Cited
2009
Using the Technological, Pedagogical, and Content Knowledge Framework to Design Online Learning Environments and Professional Development
In this article we sought to understand how social studies teachers' metacognitive awareness of their technological, pedagogical… Expand
Highly Cited
1999
Highly Cited
1999
Angiotensin II induces interleukin-6 transcription in vascular smooth muscle cells through pleiotropic activation of nuclear factor-kappa B transcription factors.
Interleukin-6 (IL-6) is a multifunctional cytokine expressed by angiotensin II (Ang II)-stimulated vascular smooth muscle cells… Expand
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Highly Cited
1997
Highly Cited
1997
Internucleosomal DNA cleavage triggered by plasma membrane damage during necrotic cell death. Involvement of serine but not cysteine proteases.
Autolytic DNA breakdown, detected as smears in electrophoretic gels, is a late event in necrosis. On the other hand… Expand
Highly Cited
1996
Highly Cited
1996
Inhibition of NF‐kappaB/Rel induces apoptosis of murine B cells.
Apoptosis of the WEHI 231 immature B cell lymphoma line following membrane interaction with an antibody against the surface IgM… Expand
Highly Cited
1995
Highly Cited
1995
Identification of actin as a substrate of ICE and an ICE-like protease and involvement of an ICE-like protease but not ICE in VP-16-induced U937 apoptosis.
Human leukemia U937 cells are induced to undergo apoptosis by several chemotherapeutic agents; however, the cellular components… Expand
Highly Cited
1989
Highly Cited
1989
Yeast prohormone processing enzyme (KEX2 gene product) is a Ca2+-dependent serine protease.
The KEX2-encoded endoprotease was overproduced in yeast several hundred-fold and further purified to achieve a 10,000-fold… Expand
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Highly Cited
1976
Highly Cited
1976
Binding of chloromethyl ketone substrate analogues to crystalline papain.
Papain (EC 3.4.22.2) is a proteolytic enzyme, the three-dimensional structure of which has been determined by x-ray diffraction… Expand
Highly Cited
1967
Highly Cited
1967
Research report
  • R. Acevedo
  • Revista odontologica de Puerto Rico
  • 1967
    • Corpus ID: 3083154
In this study, the proteolytic activity in the midgut of Ectomyelois ceratoniae as the major pest of pomegranate was investigated… Expand
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