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Tosylphenylalanyl Chloromethyl Ketone

Known as: Chlorophenyltosylamidobutanone, Chloromethyl Ketone, Tosylphenylalanyl, Chloromethane, Tosylphenylalanyl 
An inhibitor of Serine Endopeptidases. Acts as alkylating agent and is known to interfere with the translation process.
National Institutes of Health

Papers overview

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Highly Cited
2002
Highly Cited
2002
Inflammatory mediators including chemokines play a critical role in acute pancreatitis. The precise nature of early inflammatory… 
Highly Cited
2000
Highly Cited
2000
We have shown that reoxygenation of hypoxic rat kidney proximaltubule cells leads to apoptosis. This is mediated by translocation… 
Highly Cited
1996
Highly Cited
1996
Both human neutrophil elastase (HNE) and free chymotrypsin (Chtr) proteolyze Chtr within the complex that Chtr forms with… 
Highly Cited
1993
Highly Cited
1993
Summary The sperm plasma membrane over the equatorial segment of the acrosome gains the ability to fuse with the oolemma some… 
Highly Cited
1982
Highly Cited
1982
Lysates of secretory granules from rat pituitary neurointermediate lobes were incubated with [3H]arginine- or [3H]phenylalanine… 
Highly Cited
1980
Highly Cited
1980
Assay of solubilized dog pancreas microsomes revealed the presence of an endopeptidase which hydrolyzed the fluorogenic peptide… 
Highly Cited
1979
Highly Cited
1979
The effects of trypsin inhibitors and phospholipase inhibitors on the acrosome reaction of washed cauda epididymal sperm of… 
Highly Cited
1976
Highly Cited
1976
Partially purified proacrosin, the zymogen form of acrosin was obtained from unwashed hamster cauda epididymal spermatozoa by… 
Highly Cited
1976
Highly Cited
1976
Membrane fraction RNA isolated from rat pituitary tumor (GC) cells has been translated in a wheat germ extract. A product was…