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Tosylphenylalanyl Chloromethyl Ketone

Known as: Chlorophenyltosylamidobutanone, Chloromethyl Ketone, Tosylphenylalanyl, Chloromethane, Tosylphenylalanyl 
An inhibitor of Serine Endopeptidases. Acts as alkylating agent and is known to interfere with the translation process.
National Institutes of Health

Related topics

Related topics

11 relations

Broader (3)

Alkylating AgentsProtein Synthesis InhibitorsSerine Proteinase Inhibitors
In Bloodagonistsanalogs & derivativesantagonists & inhibitors

Narrower (1)

tyrosyl-valyl-alanyl-aspartic acid fluoromethyl ketone

Papers overview

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2013
2013
Using TPCK as a lens to study the practices of math and science teachers involved in a year-long technology integration initiative
1985
1985
The mechanism of human NK cell-mediated cytotoxicity. Mode of action of surface-associated proteases in the early stages of the lytic reaction.
The possible involvement of cell surface-associated proteolytic enzymes in human NK cell-mediated cytotoxicity and the mechanism… 
1985
1985
Dissociation between aggregation and superoxide production in human granulocytes.
Aggregation and the activation of the granulocyte (PMN) superoxide (O2-) generating system occur when certain stimuli are added… 
1982
1982
Con-A-stimulated superoxide production by granulocytes: reversible activation of NADPH oxidase.
Stimulation of granulocyte (PMN) superoxide (O2-) production by concanavalin-A (Con-A) can be monitored continuously in the… 
1982
1982
Simian virus 40 (SV40)-specific isoelectric point-4.7--94,000-Mr membrane glycoprotein: major peptide homology exhibited with the nuclear and membrane-associated 94,000-Mr SV40 T-antigen in hamsters.
Tryptic peptide maps of electrophoretically purified 94,000-molecular weight (relative) (Mr) nuclear and membrane-associated… 
1981
1981
Amino acid sequence of phospholipase A from Bungarus multicinctus venom.
Bungarus multicinctus phospholipase A was reduced and carboxymethylated. The RCM-enzyme was digested with TPCK-trypsin or cleaved… 
1979
1979
Chemotactic factor-induced superoxide radical generation by human neutrophils: requirement for proteinase (esterase) activity.
The requirement for proteinase (esterase) activity in the generation of O2- by human peripheral neutrophils was investigated… 
1975
1975
Studies on the mechanism of hyaluronate lyase action.
Hyaluronate lyase from streptococci group A was purified by chromatography on DEAE-Sephadex A-50 and on Biogel P-150, thereby… 
1974
1974
Non-selective inhibition of transformed cell growth by a protease inhibitor.
The protease inhibitors N-tosyl-L-phenylalanylchloromethyl ketone (TPCK) and N-tosyl-L-lysylchloromethyl ketone (TLCK) have… 
1972
1972
Selective Inhibition of the Synthesis of Sindbis Virion Proteins by an Inhibitor of Chymotrypsin
Treatment of chick embryo fibroblasts infected with Sindbis virus with TPCK, the choloromethyl ketone derivative of tosyl…