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A novel heterodimeric cysteine protease is required for interleukin-1βprocessing in monocytes
TLDR
Purification and cloning of the complementary DNA indicates that IL-lβ-converting enzyme is composed of two nonidentical subunits that are derived from a single proenzyme, possibly by autoproteolysis. Expand
Cloning and characterization of inducible nitric oxide synthase from mouse macrophages.
TLDR
The macrophage enzyme is immunologically induced at the transcriptional level and closely resembles the enzyme in cytokine-treated tumor cells and inflammatory neutrophils. Expand
Expression of inducible nitric oxide synthase and nitrotyrosine in colonic epithelium in inflammatory bowel disease.
TLDR
Findings suggest that iNOS is induced in the inflamed human colonic epithelium and is associated with the formation of peroxynitrite and the nitration of cellular proteins. Expand
Inducible nitric oxide synthase in tangle-bearing neurons of patients with Alzheimer's disease
TLDR
Human neurons can express NOS2 in vivo, and the high-output pathway of NO production may contribute to pathogenesis in AD. Expand
IL-1-converting enzyme requires aspartic acid residues for processing of the IL-1 beta precursor at two distinct sites and does not cleave 31-kDa IL-1 alpha.
TLDR
Results show that ICE is a highly specific IL-1 beta convertase with absolute requirements for Asp in P1 and a small hydrophobic amino acid in P2', and not like any other eukaryotic protease. Expand
Cloning of the gene and cDNA for mammalian β-adrenergic receptor and homology with rhodopsin
TLDR
Cloning of the gene and cDNA for the mammalian β2AR indicates significant amino-acid homology with bovine rhodopin and suggests that, like rhodopsin7, βAR possesses multiple membrane-spanning regions. Expand
Aggrecan degradation in human cartilage. Evidence for both matrix metalloproteinase and aggrecanase activity in normal, osteoarthritic, and rheumatoid joints.
TLDR
Both neoepitopes were also detected by immunohistochemistry in articular cartilage from patients undergoing joint replacement for osteoarthritis, rheumatoid arthritis, and in Cartilage from adults with no known joint disease. Expand
Calmodulin is a subunit of nitric oxide synthase from macrophages
TLDR
It is shown that macrophage NOS contains, as a tightly bound subunit, a molecule with the immunologic reactivity, high performance liquid chromatography retention time, tryptic map, partial amino acid sequence, and exact molecular mass of CaM. Expand
Development of C5a receptor antagonists. Differential loss of functional responses.
TLDR
This work reports hexapeptides of the form NMePhe-Lys-Pro-dCha-X-dArg in which increasing aromaticity at position 5 leads to a progressive loss of agonism with little change in binding affinity, and describes the first full antagonist of C5a. Expand
Production of nitric oxide in the synovial membrane of rheumatoid and osteoarthritis patients
TLDR
The results suggest that NO may mediate pathology in RA through the induction of TNF-alpha production, and show that, although human macrophages can express high levels of iNOS, the majority of cells expressingiNOS are fibroblasts. Expand
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