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Topoisomerase Inhibitors

Known as: Topoisomerase Inhibitors, DNA, DNA Topoisomerase Inhibitors, Topoisomerase Inhibitor 
Any substance that inhibits topoisomerase, an enzyme that cleaves the DNA backbone to relieve torsional stress in a DNA molecule generated during… 
National Institutes of Health

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Related topics

9 relations
DNA Gyrase InhibitorsDNA Topoisomerases, Type IIn Bloodaspects of radiation effects

Broader (1)

Enzyme Inhibitors

Narrower (2)

MureletecanTopoisomerase I Inhibitors

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2004
2004
2-deoxy-D-glucose enhances the cytotoxicity of topoisomerase inhibitors in human tumor cell lines
Resistance of tumors due to restricted drug accumulation and reversal of DNA lesions in tumor cells as well as normal tissue… 
2000
2000
Detection of apoptosis induced by topoisomerase inhibitors and serum deprivation in syrian hamster embryo cells.
The sensitivity of normal diploid Syrian hamster embryo (SHE) cells to apoptosis was tested after treatment with the… 
1998
1998
Contribution of gene-specific lesions, DNA-replication-associated damage, and subsequent transcriptional inhibition in topoisomerase inhibitor-mediated apoptosis in lymphoma cells.
Lymphoid lineage tumor cells differ widely in their relative sensitivity or resistance to the induction of apoptosis by a variety… 
Highly Cited
1997
Highly Cited
1997
Activation of PKCα Downstream from Caspases during Apoptosis Induced by 7-Hydroxystaurosporine or the Topoisomerase Inhibitors, Camptothecin and Etoposide, in Human Myeloid Leukemia HL60 Cells*
We previously demonstrated that the anticancer agent and protein kinase C (PKC) inhibitor 7-hydroxystaurosporine (UCN-01) induces… 
1996
1996
Molecular cloning of the genes suppressed in RVC lymphoma cells by topoisomerase inhibitors.
Etoposide is a topoisomerase II inhibitor that induces DNA cleavable complex and has been used as an antitumor drug. We isolated… 
1994
1994
Differential induction of chromosomal aberrations by topoisomerase inhibitors in cultured Chinese hamster cells.
The inducibility of chromosomal aberration was studied using five mammalian topoisomerase inhibitors in Chinese hamster lung… 
Highly Cited
1993
Highly Cited
1993
Cellular and chromosomal hypersensitivity to DNA crosslinking agents and topoisomerase inhibitors in the radiosensitive Chinese hamster irs mutants: phenotypic similarities to ataxia telangiectasia…
The mutants irs1, irs2 and irs3 were previously isolated from the Chinese hamster line V79-4 on the basis of their… 
Highly Cited
1991
Highly Cited
1991
Topoisomerase Inhibitors Have Potent Differentiation‐inducing Activity for Human and Mouse Myeloid Leukemia Cells
DNA topoisomerase inhibitors, camptothecin and 4′‐demethylepipodophyllotoxin ethylidene‐jS‐D‐glucoside (VP16) had strong… 
1990
1990
Rapid evaluation of topoisomerase inhibitors: caffeine inhibition of topoisomerases in vivo.
Caffeine was found to inhibit both type I and type II topoisomerases in vivo as judged by its effects on replicating simian virus… 
Highly Cited
1988
Highly Cited
1988
Topoisomerase inhibitors induce irreversible fragmentation of replicated DNA in concanavalin A stimulated splenocytes.
Etoposide, a nonintercalative antitumor drug, is known to inhibit topoisomerase II. Its effects have been tested in concanavalin… 
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