Topoisomerase Inhibitors

Known as: Topoisomerase Inhibitors, DNA, DNA Topoisomerase Inhibitors, Topoisomerase Inhibitor 
Any substance that inhibits topoisomerase, an enzyme that cleaves the DNA backbone to relieve torsional stress in a DNA molecule generated during… (More)
National Institutes of Health

Topic mentions per year

Topic mentions per year

1983-2018
0204019832018

Papers overview

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Highly Cited
2010
Highly Cited
2010
The serine/threonine kinase Akt lies at a critical signaling node downstream of phosphatidylinositol-3-kinase and is important in… (More)
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2006
2006
Novel Gram-positive (Gram+) antibacterial compounds consisting of a DNA polymerase IIIC (pol IIIC) inhibitor covalently connected… (More)
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2005
2005
Only four drugs are available for chemotherapy of human African sleeping sickness with undesirable toxic side effects. The… (More)
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2001
2001
In principle, the generation, transmission, and dissipation of supercoiling forces are determined by the arrangement of the… (More)
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Highly Cited
2001
Highly Cited
2001
The DNA mismatch repair (MMR) system is involved in the correction of base/base mismatches and insertion/deletion loops arising… (More)
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Highly Cited
1999
Highly Cited
1999
UNLABELLED Replication protein A (RPA) is a DNA single-strand binding protein essential for DNA replication, recombination and… (More)
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Highly Cited
1998
Highly Cited
1998
Werner syndrome (WS) is an autosomal recessive disorder characterized by genomic instability and the premature onset of a number… (More)
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Highly Cited
1995
Highly Cited
1995
Viral vectors based on adeno-associated virus (AAV) preferentially transduce cells in S phase of the cell cycle. We recently… (More)
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Highly Cited
1989
Highly Cited
1989
The cytotoxicity of topoisomerase inhibitors is thought to result from the induction of enzyme-mediated DNA breaks. The fact that… (More)
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Highly Cited
1989
Highly Cited
1989
Topoisomerase inhibitors comprise an important group of agents that is used in cancer treatment. Because the development of… (More)
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