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Tissue Inhibitor of Metalloproteinase-2

Known as: Tissue Inhibitor of Metalloproteinase 2, Metalloproteinase-2 Tissue Inhibitor, Tissue Inhibitor of Metalloproteinase-2 [Chemical/Ingredient] 
A member of the family of TISSUE INHIBITOR OF METALLOPROTEINASES. It is a 21-kDa nonglycosylated protein found in tissue fluid and is secreted as a… Expand
National Institutes of Health

Related topics

Related topics

13 relations

Narrower (2)

111In-DTPA-N-TIMP-2TIMP2 protein, human
In BloodProcess of secretionTIMP2 geneagonists
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Broader (2)

Matrix Metalloproteinase InhibitorsProteins

Papers overview

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Highly Cited
2010
Highly Cited
2010
Expression of TGF, matrix metalloproteinases, and tissue inhibitors in Chinese chronic rhinosinusitis.
BACKGROUND To date there is no information on the expression of mediators associated with tissue remodeling in Asian patients… Expand
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Highly Cited
2007
Highly Cited
2007
Epigenetic inactivation of the tissue inhibitor of metalloproteinase-2 (TIMP-2) gene in human prostate tumors
Gene silencing via CpG island methylation in the promoter region is one of the mechanisms by which tumor suppressor genes are… Expand
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Highly Cited
2003
Highly Cited
2003
TIMP-2 (tissue inhibitor of metalloproteinase-2) regulates MMP-2 (matrix metalloproteinase-2) activity in the extracellular environment after pro-MMP-2 activation by MT1 (membrane type 1)-MMP.
The matrix metalloproteinase (MMP)-2 has a crucial role in extracellular matrix degradation associated with cancer metastasis and… Expand
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Highly Cited
2002
Highly Cited
2002
Matrix metalloproteinase-2, membranous type 1 matrix metalloproteinase, and tissue inhibitor of metalloproteinase-2 expression in ectopic and eutopic endometrium.
OBJECTIVE To investigate expression of matrix metalloproteinase-2 (MMP-2), membranous type 1 matrix metalloproteinase (MT1-MMP… Expand
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Highly Cited
1997
Highly Cited
1997
Kinetic Analysis of the Binding of Human Matrix Metalloproteinase-2 and -9 to Tissue Inhibitor of Metalloproteinase (TIMP)-1 and TIMP-2*
The dissociation constants (K d ) of tissue inhibitor of metalloproteinase (TIMP)-1 and TIMP-2 for the active and latent forms of… Expand
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Highly Cited
1996
Highly Cited
1996
The Soluble Catalytic Domain of Membrane Type 1 Matrix Metalloproteinase Cleaves the Propeptide of Progelatinase A and Initiates Autoproteolytic Activation
It has been proposed that the cell-mediated activation of progelatinase A requires binding of the C-terminal domain of the… Expand
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Highly Cited
1996
Highly Cited
1996
High levels of tissue inhibitor of metalloproteinase-2 (TIMP-2) expression are associated with poor outcome in invasive bladder cancer.
The matrix metalloproteinases (MMPs) and the tissue inhibitors of metalloproteinases (TIMPs) have been associated with tumor… Expand
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Highly Cited
1993
Highly Cited
1993
Tissue inhibitor of metalloproteinases-2 inhibits bFGF-induced human microvascular endothelial cell proliferation.
Tissue inhibitor of metalloproteinase-2 (TIMP-2), a protease inhibitor that binds to the latent and active forms of 72 kDa type… Expand
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Highly Cited
1992
Highly Cited
1992
Tissue inhibitor of metalloproteinase-2 (TIMP-2) has erythroid-potentiating activity.
Tissue inhibitor of metalloproteinase (TIMP) was purified and molecularly cloned on the basis of its erythroid-potentiating… Expand
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Highly Cited
1990
Highly Cited
1990
Tissue inhibitor of metalloproteinases-2 (TIMP-2) mRNA expression in tumor cell lines and human tumor tissues.
Human tissue inhibitor of metalloproteinase-2 (TIMP-2) was cloned and sequenced from an A2058 human melanoma cell cDNA library… Expand
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