FAQ

Tissue Inhibitor of Metalloproteinase-2

Known as: Tissue Inhibitor of Metalloproteinase 2, Metalloproteinase-2 Tissue Inhibitor, Tissue Inhibitor of Metalloproteinase-2 [Chemical/Ingredient] 
A member of the family of TISSUE INHIBITOR OF METALLOPROTEINASES. It is a 21-kDa nonglycosylated protein found in tissue fluid and is secreted as a… (More)
National Institutes of Health

Topic mentions per year

Topic mentions per year

1990-2018
05019902018

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Related topics

13 relations

Narrower (2)

111In-DTPA-N-TIMP-2TIMP2 protein, human
In BloodProcess of secretionTIMP2 geneagonists
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Broader (2)

Matrix Metalloproteinase InhibitorsProteins

Related mentions per year

Related mentions per year

1936-2018
19401960198020002020
Tissue Inhibitor of Metalloproteinase-2
physiological aspects
In Blood
Proteins
chemical synthesis
Matrix Metalloproteinase Inhibitors

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2007
2007
Epigenetic inactivation of the tissue inhibitor of metalloproteinase-2 (TIMP-2) gene in human prostate tumors
Gene silencing via CpG island methylation in the promoter region is one of the mechanisms by which tumor suppressor genes are… (More)
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Highly Cited
2006
Highly Cited
2006
Shp-1 mediates the antiproliferative activity of tissue inhibitor of metalloproteinase-2 in human microvascular endothelial cells.
The tissue inhibitors of metalloproteinases (TIMPs) regulate matrix metalloproteinase activity required for cell migration… (More)
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Highly Cited
2001
Highly Cited
2001
Expression of matrix metalloproteinases and tissue inhibitors of metalloproteinases in human pancreatic adenocarcinomas: clinicopathologic and prognostic significance of matrilysin expression.
PURPOSE A disruption in the balance between the matrix metalloproteinases (MMPs) and their natural inhibitors, tissue inhibitors… (More)
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Highly Cited
2000
Highly Cited
2000
Binding of active (57 kDa) membrane type 1-matrix metalloproteinase (MT1-MMP) to tissue inhibitor of metalloproteinase (TIMP)-2 regulates MT1-MMP processing and pro-MMP-2 activation.
Previous studies have shown that membrane type 1-matrix metalloproteinase (MT1-MMP) (MMP-14) initiates pro-MMP-2 activation in a… (More)
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Highly Cited
1998
Highly Cited
1998
Localization of matrix metalloproteinases-1, -2, and -9 and tissue inhibitor of metalloproteinase-2 in interstitial lung diseases.
In interstitial lung diseases, deposition of extracellular matrix (ECM) in alveoli and degradation of ECM lead to pulmonary… (More)
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Highly Cited
1998
Highly Cited
1998
Prognostic values of matrix metalloproteinase-2 and tissue inhibitor of metalloproteinase-2 expression in bladder cancer.
BACKGROUND Matrix metalloproteinase-2 (MMP-2), which degrades the extracellular matrix or the basement membrane, has an essential… (More)
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Highly Cited
1998
Highly Cited
1998
Tissue inhibitor of metalloproteinase-2 (TIMP-2) binds to the catalytic domain of the cell surface receptor, membrane type 1-matrix metalloproteinase 1 (MT1-MMP).
It has been proposed that tissue inhibitor of metalloproteinase-2 (TIMP-2), in stoichiometric concentrations, serves as an… (More)
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Highly Cited
1997
Highly Cited
1997
Kinetic analysis of the binding of human matrix metalloproteinase-2 and -9 to tissue inhibitor of metalloproteinase (TIMP)-1 and TIMP-2.
The dissociation constants (Kd) of tissue inhibitor of metalloproteinase (TIMP)-1 and TIMP-2 for the active and latent forms of… (More)
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Highly Cited
1993
Highly Cited
1993
Tissue inhibitor of metalloproteinases-2 inhibits bFGF-induced human microvascular endothelial cell proliferation.
Tissue inhibitor of metalloproteinase-2 (TIMP-2), a protease inhibitor that binds to the latent and active forms of 72 kDa type… (More)
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Highly Cited
1990
Highly Cited
1990
Tissue inhibitor of metalloproteinases-2 (TIMP-2) mRNA expression in tumor cell lines and human tumor tissues.
Human tissue inhibitor of metalloproteinase-2 (TIMP-2) was cloned and sequenced from an A2058 human melanoma cell cDNA library… (More)
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