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Tissue Inhibitor of Metalloproteinase-2

Known as: Tissue Inhibitor of Metalloproteinase 2, Metalloproteinase-2 Tissue Inhibitor, Tissue Inhibitor of Metalloproteinase-2 [Chemical/Ingredient] 
A member of the family of TISSUE INHIBITOR OF METALLOPROTEINASES. It is a 21-kDa nonglycosylated protein found in tissue fluid and is secreted as a… 
National Institutes of Health

Related topics

Related topics

13 relations

Narrower (2)

111In-DTPA-N-TIMP-2TIMP2 protein, human
In BloodProcess of secretionTIMP2 geneagonists

Broader (2)

Matrix Metalloproteinase InhibitorsProteins

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2013
2013
S-adenosylmethionine, a methyl donor, up regulates tissue inhibitor of metalloproteinase-2 in colorectal cancer.
DNA methylation is a fundamental epigenetic mechanism in regulating the expression of genes controlling crucial cell functions in… 
2007
2007
Strong association of the tissue inhibitor of metalloproteinase-2 polymorphism with an increased risk of oral squamous cell carcinoma in Europeans.
The present study was performed in order to investigate the possible association of the -418 G/C polymorphism in the tissue… 
2005
2005
Protein profiles of bovine placenta derived from somatic cell nuclear transfer
Practical application of animal cloning by somatic cell nuclear transfer (SCNT) has been hampered by an extremely low success… 
2005
2005
Quantification of Tissue Inhibitor of Metalloproteinases 2 in Plasma from Healthy Donors and Cancer Patients
Tissue inhibitor of metalloproteinases (TIMP)‐2 is a highly conserved molecule, which binds both active and latent matrix… 
2004
2004
Retroviral delivery of TIMP-2 inhibits H-ras-induced migration and invasion in MCF10A human breast epithelial cells.
Highly Cited
2002
Highly Cited
2002
IL-4 Up-Regulates the Expression of Tissue Inhibitor of Metalloproteinase-2 in Dermal Fibroblasts Via the p38 Mitogen-Activated Protein Kinase-Dependent Pathway1
Tissue inhibitor of metalloproteinase-2 (TIMP-2) is a potent inhibitor of activated matrix metalloproteinases such as gelatinase… 
Highly Cited
2002
Highly Cited
2002
MT1‐MMP, but not secreted MMPs, influences the migration of human microvascular endothelial cells in 3‐dimensional collagen gels
Matrix metalloproteinases (MMPs) and their specific inhibitors the TIMPs play significant roles in angiogenesis. We investigated… 
Highly Cited
1999
Highly Cited
1999
The Specificity of TIMP-2 for Matrix Metalloproteinases Can Be Modified by Single Amino Acid Mutations*
Residues 1–127 of human TIMP-2 (N-TIMP-2), comprising three of the disulfide-bonded loops of the TIMP-2 molecule, is a discrete… 
1998
1998
The membrane-type-matrix metalloproteinase/matrix metalloproteinase-2/tissue inhibitor of metalloproteinase-2 system in periprosthetic connective-tissue remodeling in loose total-hip prostheses.
The aim of the present study was to investigate the proteolytic potential and localization of matrix metalloproteinase (MMP)-2 in… 
Highly Cited
1993
Highly Cited
1993
Role and regulation of expression of 92‐kDa type‐IV collagenase (MMP‐9) in 2 invasive squamous‐cell‐carcinoma cell lines of the oral cavity
The present study was undertaken to determine the role of the metalloproteinase MMP‐9 in the invasive phenotype of squamous‐cell… 
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