Matrix Metalloproteinase Inhibitors

Known as: Metalloproteinase Inhibitors, Matrix, Inhibitors, MMP, Matrix Metalloproteinase Inhibitor 
Any substance that inhibits matrix metalloproteinase (MMP), an endopeptidase that degrades components of the extracellular matrix during tissue… (More)
National Institutes of Health

Related topics

Related topics

32 relations

Narrower (27)

3,4,5-trihydroxybenzaldehyde4-des-dimethylaminotetracyclineCGS 27023CH1766
(More)
Collagenase InhibitorIn Bloodaspects of radiation effectschemical synthesis
(More)

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2007
Highly Cited
2007
Matrix metalloproteinase-mediated disruption of tight junction proteins in cerebral vessels is reversed by synthetic matrix metalloproteinase inhibitor in focal ischemia in rat.
Matrix metalloproteinases (MMPs) disrupt the blood-brain barrier (BBB) during reperfusion. Occludin and claudins are recently… (More)
  • table 1
  • figure 1
  • figure 2
  • figure 3
  • figure 4
Is this relevant?
Review
2006
Review
2006
Towards third generation matrix metalloproteinase inhibitors for cancer therapy
The failure of matrix metalloproteinase (MMP) inhibitor drug clinical trials in cancer was partly due to the inadvertent… (More)
  • figure 1
  • figure 2
Is this relevant?
Highly Cited
2003
Highly Cited
2003
Differential effects of doxycycline, a broad-spectrum matrix metalloproteinase inhibitor, on angiotensin II-induced atherosclerosis and abdominal aortic aneurysms.
OBJECTIVE Angiotensin II (AngII) infusion into hyperlipidemic mice leads to the rapid formation of atherosclerotic lesions and… (More)
  • table 1
  • figure 1
  • figure 2
  • figure 3
  • table 2
Is this relevant?
Review
2002
Review
2002
Development of matrix metalloproteinase inhibitors in cancer therapy.
The matrix metalloproteinases represent an attractive target for cancer treatment, and a number of matrix metalloproteinase… (More)
Is this relevant?
Highly Cited
2002
Highly Cited
2002
Phase II trial of temozolomide plus the matrix metalloproteinase inhibitor, marimastat, in recurrent and progressive glioblastoma multiforme.
PURPOSE Novel therapies are needed for patients with recurrent glioblastoma multiforme (GBM). Because there is evidence that… (More)
Is this relevant?
Highly Cited
2001
Highly Cited
2001
The Membrane-Anchored MMP Inhibitor RECK Is a Key Regulator of Extracellular Matrix Integrity and Angiogenesis
Matrix metalloproteinases (MMPs) are essential for proper extracellular matrix remodeling. We previously found that a membrane… (More)
  • figure 1
  • figure 2
  • figure 3
  • figure 4
  • figure 5
Is this relevant?
Highly Cited
2001
Highly Cited
2001
Moderation of iodoacetate-induced experimental osteoarthritis in rats by matrix metalloproteinase inhibitors.
OBJECTIVE To determine the effect of matrix metalloproteinase (MMP) inhibitors in mono-iodoacetate-induced arthritis in rats… (More)
Is this relevant?
Highly Cited
2001
Highly Cited
2001
Hydroxamate-type matrix metalloproteinase inhibitor batimastat promotes liver metastasis.
Overexpression of matrix metalloproteinases (MMPs) facilitates tumor cell invasion. Synthetic MMP inhibitors such as batimastat… (More)
  • figure 2
  • figure 1
  • figure 3
Is this relevant?
Review
1999
Review
1999
Clinical studies with matrix metalloproteinase inhibitors.
  • P D Brown
  • APMIS : acta pathologica, microbiologica, et…
  • 1999
Matrix metalloproteinases (MMPs) have been implicated in the invasive growth and spread of tumours. Potent and selective… (More)
Is this relevant?
Review
1997
Review
1997
Matrix metalloproteinase inhibitors
The matrix metalloproteinases (MMPs) are a family of at least fifteen secreted and membrane-bound zinc-endopeptidases… (More)
  • table 1
  • figure 1
  • table 2
  • figure 2
  • figure 3
Is this relevant?