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Matrix Metalloproteinase Inhibitors

Known as: Metalloproteinase Inhibitors, Matrix, Inhibitors, MMP, Matrix Metalloproteinase Inhibitor 
Any substance that inhibits matrix metalloproteinase (MMP), an endopeptidase that degrades components of the extracellular matrix during tissue… Expand
National Institutes of Health

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Related topics

33 relations

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3,4,5-trihydroxybenzaldehyde4-des-dimethylaminotetracyclineCGS 27023CH1766
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Collagenase InhibitorIn Bloodaspects of radiation effectschemical synthesis
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Papers overview

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Review
2019
Review
2019
Mechanistic insight into diabetic wounds: Pathogenesis, molecular targets and treatment strategies to pace wound healing.
Wound management in diabetic patient is of an extreme clinical and social concern. The delayed and impaired healing makes it more… Expand
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Highly Cited
2007
Highly Cited
2007
Matrix Metalloproteinase-Mediated Disruption of Tight Junction Proteins in Cerebral Vessels is Reversed by Synthetic Matrix Metalloproteinase Inhibitor in Focal Ischemia in Rat
Matrix metalloproteinases (MMPs) disrupt the blood—brain barrier (BBB) during reperfusion. Occludin and claudins are recently… Expand
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Review
2006
Review
2006
Towards third generation matrix metalloproteinase inhibitors for cancer therapy
The failure of matrix metalloproteinase (MMP) inhibitor drug clinical trials in cancer was partly due to the inadvertent… Expand
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Highly Cited
2003
Highly Cited
2003
Differential Effects of Doxycycline, a Broad-Spectrum Matrix Metalloproteinase Inhibitor, on Angiotensin II–Induced Atherosclerosis and Abdominal Aortic Aneurysms
Objective—Angiotensin II (AngII) infusion into hyperlipidemic mice leads to the rapid formation of atherosclerotic lesions and… Expand
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Highly Cited
2003
Highly Cited
2003
Comparison of gemcitabine versus the matrix metalloproteinase inhibitor BAY 12-9566 in patients with advanced or metastatic adenocarcinoma of the pancreas: a phase III trial of the National Cancer…
PURPOSE To compare the selective matrix metalloproteinase inhibitor BAY 12-9566 with the nucleoside analog gemcitabine in the… Expand
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Review
2001
Review
2001
Development of matrix metalloproteinase inhibitors in cancer therapy.
The matrix metalloproteinases (MMPs) are a family of zinc-dependent proteinases involved in the degradation of the extracellular… Expand
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Highly Cited
2001
Highly Cited
2001
The Membrane-Anchored MMP Inhibitor RECK Is a Key Regulator of Extracellular Matrix Integrity and Angiogenesis
Matrix metalloproteinases (MMPs) are essential for proper extracellular matrix remodeling. We previously found that a membrane… Expand
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Highly Cited
1999
Highly Cited
1999
Design and therapeutic application of matrix metalloproteinase inhibitors.
 
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Highly Cited
1999
Highly Cited
1999
Analysis of the acute and chronic wound environments: the role of proteases and their inhibitors
To assess the differences in proteolytic activity of acute and chronic wound environments, wound fluids were collected from acute… Expand
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Highly Cited
1998
Highly Cited
1998
Effect of matrix metalloproteinases activity on outflow in perfused human organ culture.
PURPOSE To test the hypothesis that extracellular matrix turnover, mediated by the matrix metalloproteinases, modulates aqueous… Expand
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