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TIMP2 protein, human

Known as: tissue inhibitor of metalloproteinase 2, human, Tissue Inhibitor of Metalloproteinases 2, TIMP metallopeptidase inhibitor 2 protein, human 
Metalloproteinase inhibitor 2 (220aa, ~24 kDa) is encoded by the human TIMP2 gene. This protein plays a role in metalloproteinase inhibition.
National Institutes of Health

Papers overview

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Highly Cited
2017
Highly Cited
2017
Ageing drives changes in neuronal and cognitive function, the decline of which is a major feature of many neurological disorders… Expand
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2006
2006
The degradation of the extracellular matrix is regulated by matrix metalloproteinases (MMPs) and tissue inhibitors of… Expand
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Highly Cited
2004
Highly Cited
2004
The low density lipoprotein receptor-related protein (LRP) mediates the endocytic clearance of various proteinases and proteinase… Expand
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Highly Cited
2003
Highly Cited
2003
Tissue inhibitors of metalloproteinases (TIMPs) suppress matrix metalloproteinase (MMP) activity critical for extracellular… Expand
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Highly Cited
2003
Highly Cited
2003
The matrix metalloproteinase (MMP)-2 has a crucial role in extracellular matrix degradation associated with cancer metastasis and… Expand
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Highly Cited
2000
Highly Cited
2000
Previous studies have shown that membrane type 1-matrix metalloproteinase (MT1-MMP) (MMP-14) initiates pro-MMP-2 activation in a… Expand
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Highly Cited
2000
Highly Cited
2000
The hypothesis that thrombospondin-1 (TSP-1) can exert opposite effects on angiogenesis depending on the functional status of its… Expand
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Highly Cited
2000
Highly Cited
2000
To understand the biologic function of TIMP-2, a member of the tissue inhibitors of metalloproteinases family, an inactivating… Expand
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Highly Cited
1997
Highly Cited
1997
Membrane type 1 matrix metalloproteinase (MT1-MMP) is expressed on cancer cell membranes and activates the zymogen of MMP-2… Expand
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Highly Cited
1993
Highly Cited
1993
Human 72-kDa type IV collagenase (72T4Cl) is secreted as a proenzyme that can form a specific stoichiometric complex with the… Expand
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