TIMP2 protein, human

Known as: tissue inhibitor of metalloproteinase 2, human, Tissue Inhibitor of Metalloproteinases 2, TIMP metallopeptidase inhibitor 2 protein, human 
Metalloproteinase inhibitor 2 (220aa, ~24 kDa) is encoded by the human TIMP2 gene. This protein plays a role in metalloproteinase inhibition.
National Institutes of Health

Topic mentions per year

Topic mentions per year

1989-2018
051019892018

Papers overview

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2009
2009
Membrane type-1 matrix metalloproteinase (MT1-MMP) is an activator of soluble MMP-2. The activity of both MMPs is regulated by… (More)
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2007
2007
Gene therapy may be a promising approach for treatment of brain ischemia. We and others previously demonstrated that increased… (More)
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2005
2005
OBJECTIVE The influence of the cruciate ligaments in spontaneous osteoarthritis (OA) is not understood, although ligament rupture… (More)
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2004
2004
One well documented family of enzymes responsible for the proteolytic processes that occur in the extracellular matrix is the… (More)
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2001
2001
Membrane-type matrix metalloproteinase 1 (MT1-MMP) is a membrane-anchored matrix metalloproteinase (MMP) that is frequently… (More)
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2000
2000
TIMP-2 is an endogenous inhibitor of MMPs. Most data from model systems suggest that high levels of this inhibitor prevent… (More)
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1998
1998
Activation of secreted latent matrix metalloproteinases (MMPs) is accompanied by cleavage of the N-terminal propeptide, thereby… (More)
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1998
1998
The cell-surface activation of pro-matrix metalloproteinase 2 (pro-MMP-2) is considered to be critical for cell migration and… (More)
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Highly Cited
1997
Highly Cited
1997
Membrane type 1 matrix metalloproteinase (MT1-MMP) is expressed on cancer cell membranes and activates the zymogen of MMP-2… (More)
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1991
1991
To study the activation of human 72-kDa gelatinase, and its relation to tissue inhibitor of metalloproteinases 2 (TIMP-2), we… (More)
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