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Inhibition of Endoplasmic Reticulum Stress Improves Mouse Embryo Development
TLDR
The data collectively suggest that endogenous XBP-1 plays a role in normal preimplantation embryonic development and TUDCA inhibits hyperosmolar-induced ER stress as well as ER stress-induced apoptosis during mouse preIMplantation embryo development. Expand
Lysophosphatidic acid improves porcine oocyte maturation and embryo development in vitro
TLDR
Comparing the developmental competence of porcine embryos created via in vitro fertilization and parthenogenetic activation in culture medium supplemented with LPA indicates that LPA supplementation improves Porcine oocyte maturation and subsequent in vitro development of pre‐implantation embryos. Expand
Endoplasmic Reticulum (ER) Stress and Unfolded Protein Response (UPR) in Mammalian Oocyte Maturation and Preimplantation Embryo Development
TLDR
The current state of knowledge regarding ER stress, UPR signaling pathways, and their roles and mechanisms in mammalian (excluding human) oocyte maturation and preimplantation embryo development are described. Expand
Treatment of fetal fibroblasts with DNA methylation inhibitors and/or histone deacetylase inhibitors improves the development of porcine nuclear transfer-derived embryos.
TLDR
Results indicate that treatment of donor cells with 5-aza-dC, TSA, or TSA plus a low dose of 5-aze-dD could improve the blastocyst development of porcine cloned embryos. Expand
Targeted disruption of hsp70.1 sensitizes to osmotic stress
TLDR
It is demonstrated that differential expression of hSp70 genes contributes to the stress response and that the hsp70.1 gene plays a critical role in osmotolerance. Expand
Alterations in differentiation and behavior of monocytic phagocytes in transgenic mice that express dominant suppressors of ras signaling
TLDR
The results indicate that ras action is critical in monocytic cells after these cells have lost the capacity to traverse the cell cycle. Expand
HSP90 protects apoptotic cleavage of vimentin in geldanamycin-induced apoptosis
TLDR
The results suggest that HSP90 protects vimentin by physical interaction in the geldanamycin-induced apoptotic pathway. Expand
Production of transgenic recloned piglets harboring the human granulocyte-macrophage colony stimulating factor (hGM-CSF) gene from porcine fetal fibroblasts by nuclear transfer.
TLDR
It is demonstrated that somatic cells derived from a cloned fetus can be used to produce recloned and transgenic pigs. Expand
Effects of teat number on litter size in gilts.
TLDR
Investigation of the effects of teat number and interval at first estrus and mating on litter size in Duroc, Landrace and Yorkshire gilts found 14 or more teats compared to 11-13 teats increased litter size at birth and at 21 day weaning. Expand
Effect of Endoplasmic Reticulum Stress on Porcine Oocyte Maturation and Parthenogenetic Embryonic Development In Vitro1
TLDR
Results indicated that inhibition of ER stress enhanced porcine oocyte maturation and embryonic development by preventing ER stress-mediated apoptosis in vitro. Expand
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