Ticrynafen

Known as: 4-(2-Thienylketo)-2,3-dichlorophenoxyacetic acid, Tienilic acid, Acido tienilico 
A novel diuretic with uricosuric action. It has been proposed as an antihypertensive agent.
National Institutes of Health

Papers overview

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2009
2009
1-Aminobenzotriazole (1-ABT) is generally considered to be a nonselective mechanism-based inactivator of both human and non-human… (More)
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2009
2009
Prediction of idiosyncratic drug-induced liver injury (DILI) is difficult, and the underlying mechanisms are not fully understood… (More)
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2009
2009
1. Recent guidance from the US Food and Drug Administration (USFDA) has advocated testing of time-dependent inhibition of… (More)
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Review
2009
Review
2009
Cytochrome P450 2C9 (CYP2C9) is one of the most abundant CYP enzymes in the human liver. CYP2C9 metabolizes more than 100… (More)
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Highly Cited
2008
Highly Cited
2008
In vitro covalent binding assessments of drugs have been useful in providing retrospective insights into the association between… (More)
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1997
1997
Inhibition of [14C]-urate uptake by uricosuric and antiuricosuric agents was investigated in human brush-border membrane vesicles… (More)
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1995
1995
Biochemical experiments, using the well-defined human liver CYP2C9 expressed in yeast, and molecular modeling techniques were… (More)
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Highly Cited
1987
Highly Cited
1987
"Anti-liver/kidney microsome" (anti-LKM) autoantibodies have been found in the serum of patients with cryptogenic chronic… (More)
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1984
1984
Ticrynafen, a uricosuric diuretic, was withdrawn from clinical use in the United States in 1980 after having been implicated as… (More)
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Highly Cited
1983
Highly Cited
1983
The group of “high ceiling” diuretics consists of a variety of chemically different potent diuretic and saluretic substances… (More)
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