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Ticrynafen

Known as: 4-(2-Thienylketo)-2,3-dichlorophenoxyacetic acid, Tienilic acid, Acido tienilico 
A novel diuretic with uricosuric action. It has been proposed as an antihypertensive agent.
National Institutes of Health

Related topics

Related topics

12 relations

Narrower (3)

5-hydroxythienilic acidSKF-62698Selacryn

Broader (3)

Antihypertensive AgentsDiureticsUricosuric Agents
In Bloodagonistsantagonists & inhibitorsaspects of radiation effects

Papers overview

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Highly Cited
2008
Highly Cited
2008
A generic method to detect electrophilic intermediates using isotopic pattern triggered data-dependent high-resolution accurate mass spectrometry.
A need still exists for a liquid chromatography/tandem mass spectrometry (LC/MS/MS) method that can detect broad classes of… 
Review
2001
Review
2001
INDUCTION OF CYP 2 C GENES IN HUMAN HEPATOCYTES IN PRIMARY CULTURE
The expression and inducibility of four CYP2C genes, including CYP2C8, -2C9, -2C18, and -2C19, was investigated in primary… 
2000
2000
Electrophysiologic characterization of an organic anion transporter cloned from winter flounder kidney (fROAT).
The two-electrode voltage clamp technique was used to demonstrate translocation of p-aminohippurate (PAH) and related compounds… 
Review
1997
Review
1997
Molecular structure and hepatotoxicity: compared data about two closely related thiophene compounds.
Highly Cited
1993
Highly Cited
1993
Human-liver cytochromes P-450 expressed in yeast as tools for reactive-metabolite formation studies. Oxidative activation of tienilic acid by cytochromes P-450 2C9 and 2C10.
Human liver cytochromes P-450 (P450) 2C9 and 2C10 expressed in yeast reproduce all the metabolic features of the oxidation of… 
1987
1987
A new uricosuric diuretic, S-8666, in rats and chimpanzees.
5-Dimethylsulfamoyl-6,7-dichloro-2,3-dihydrobenzofuran-2-carboxyli c acid (S-8666) was studied as a possible new uricosuric… 
1985
1985
Study of the mutagenic activity of 6 hepatotoxic pharmaceutical drugs in the Salmonella typhimurium microsome test, and the HGPRT and Na+/K+ ATPase system in cultured mammalian cells.
Highly Cited
1984
Highly Cited
1984
Ticrynafen‐Associated Hepatic Injury: Analysis of 340 Cases
Ticrynafen, a uricosuric diuretic, was withdrawn from clinical use in the United States in 1980 after having been implicated as… 
Highly Cited
1984
Highly Cited
1984
Stimulation of K+ fluxes by diuretic drugs in human red cells.
1984
1984
Metabolic hydroxylation of the thiophene ring: isolation of 5-hydroxy-tienilic acid as the major urinary metabolite of tienilic acid in man and rat.
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