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Hepatotoxicity: The adverse effects of drugs and other chemicals on the liver
TLDR
The hepatotoxic effects of oncotherapeutic and immunosuppressive agents miscellaneous drugs and diagnostic chemicals afterthoughts on hepatotoxicity appendices are described. Expand
Isoniazid liver injury: clinical spectrum, pathology, and probable pathogenesis.
The clinical spectrum of isoniazid-induced liver injury seems to be clinically, biochemically, and histologically indistinguishable from viral hepatitis, except that the injury occurs primarily inExpand
Amiodarone hepatotoxicity: Prevalence and clinicopathologic correlations among 104 patients
TLDR
The risks posed and benefits offered by amiodarone should be carefully weighed prior to discontinuing the drug, as the risk of sudden cardiac death may outweigh the hazards of ongoing hepatic, pulmonary or other toxicity. Expand
Hepatic Sarcoidosis: Clinicopathologic Features in 100 Patients
TLDR
It is clear that sarcoidosis can cause progressive liver disease with a wide array of histologic features that can mimic those of other primary liver diseases. Expand
Acetaminophen (paracetamol) hepatotoxicity with regular intake of alcohol: Analysis of instances of therapeutic misadventure
TLDR
Evidence of hepatic injury in regular users of alcohol, especially chronic alcoholics, who take APAP with therapeutic intent is provided, and the syndrome of liver injury is distinctive, marked by uniquely elevated levels of AST, and poses a significant threat. Expand
Diclofenac‐associated hepatotoxicity: Analysis of 180 cases reported to the food and drug administration as adverse reactions
TLDR
The data suggest that diclofenac‐related liver injury is particularly likely to involve osteoarthritic females, presenting with jaundice 1 to 6 months after starting dicL ofenac, with injury that is predominantly hepatocellular and presumably caused by metabolic idiosyncrasy. Expand
Valproate‐Induced Hepatic Injury: Analyses of 23 Fatal Cases
TLDR
Analyses of 23 fatal instances of hepatic injury in patients taking valproic acid reveals that all but three were less than 20 years old, and all but four had been taking the drugs for more than 1 month, leading to the plausible hypothesis that a metabolite is responsible for the microvesicular steatosis seen in most fatal cases. Expand
Hepatotoxic effects of the anabolic/androgenic steroids.
Drug-induced liver disease.
TLDR
Hepatotoxic agents can be recognised by their dose-dependent and experimental reproducibility, properties which are not shared by agents which produce hepatic injury only in idiosyncratic hosts, which may reflect allergy to the drug or a metabolic aberration of the host permitting the production of hepatotoxic metabolites. Expand
Risk of acute liver injury associated with the combination of amoxicillin and clavulanic acid.
TLDR
Among users of amoxicillin and clavulanic acid together, the risk of developing acute liver injury was more than 3 times greater after a course of 2 or more consecutive prescriptions than after a single course of therapy. Expand
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