FAQ

Thrombopoiesis

Known as: thrombocyte differentiation, Thrombocytopoiesis, platelet production 
The process of generating thrombocytes (BLOOD PLATELETS) from the pluripotent HEMATOPOIETIC STEM CELLS in the BONE MARROW via the MEGAKARYOCYTES. The… (More)

Topic mentions per year

Topic mentions per year

1937-2018
05010019372017

Related topics

Related topics

15 relations
Blood CellsBlood PlateletsMPL geneMPL protein, human
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Broader (1)

Hematopoiesis

Related mentions per year

Related mentions per year

1936-2019
19401960198020002020
Thrombopoiesis
Blood Platelets
Blood Cells
physiological aspects
Hematopoiesis
Megakaryocytopoiesis

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Review
2015
Review
2015
Current Management of Primary Immune Thrombocytopenia
Primary immune thrombocytopenia is an autoimmune disorder of unknown cause affecting both children and adults. The low peripheral… (More)
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Highly Cited
2007
Highly Cited
2007
Dynamic visualization of thrombopoiesis within bone marrow.
Platelets are generated from megakaryocytes (MKs) in mammalian bone marrow (BM) by mechanisms that remain poorly understood. Here… (More)
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Highly Cited
2007
Highly Cited
2007
Eltrombopag for the treatment of chronic idiopathic thrombocytopenic purpura.
BACKGROUND The pathogenesis of chronic idiopathic thrombocytopenic purpura (ITP) involves antibody-mediated platelet destruction… (More)
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Highly Cited
2006
Highly Cited
2006
AMG 531, a thrombopoiesis-stimulating protein, for chronic ITP.
BACKGROUND Most current treatments for chronic immune thrombocytopenic purpura (ITP) act by decreasing platelet destruction. In a… (More)
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Highly Cited
2004
Highly Cited
2004
Chemokine-mediated interaction of hematopoietic progenitors with the bone marrow vascular niche is required for thrombopoiesis
The molecular pathways involved in the differentiation of hematopoietic progenitors are unknown. Here we report that chemokine… (More)
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Highly Cited
2001
Highly Cited
2001
Interleukin-6 stimulates thrombopoiesis through thrombopoietin: role in inflammatory thrombocytosis.
Baseline platelet production is dependent on thrombopoietin (TPO). TPO is constitutively produced and primarily regulated by… (More)
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Highly Cited
2000
Highly Cited
2000
Effects of erythropoietin on platelet reactivity and thrombopoiesis in humans.
A recent study in dogs suggested that erythropoietin (EPO) not only promotes the synthesis of increased numbers of reticulated… (More)
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Highly Cited
1994
Highly Cited
1994
Stimulation of megakaryocytopoiesis and thrombopoiesis by the c-Mpl ligand.
Physiological platelet synthesis is thought to require the humoral activities of meg-CSF and thrombopoietin, which respectively… (More)
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Highly Cited
1994
Highly Cited
1994
Promotion of megakaryocyte progenitor expansion and differentiation by the c-Mpl ligand thrombopoietin.
The development of blood cells including expansion of megakaryocyte progenitor cells requires the interplay of marrow stromal… (More)
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1968
1968
Kinetics of thrombopoiesis.
Measurements of megakaryocyte number, volume, nuclear number, and cytoplasmic granulation were compared in animals with induced… (More)
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