Thrombopoiesis

Known as: thrombocyte differentiation, Thrombocytopoiesis, platelet production 
The process of generating thrombocytes (BLOOD PLATELETS) from the pluripotent HEMATOPOIETIC STEM CELLS in the BONE MARROW via the MEGAKARYOCYTES. The… (More)

Topic mentions per year

Topic mentions per year

1937-2018
05010019372017

Papers overview

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Review
2015
Review
2015
Primary immune thrombocytopenia is an autoimmune disorder of unknown cause affecting both children and adults. The low peripheral… (More)
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Highly Cited
2007
Highly Cited
2007
Platelets are generated from megakaryocytes (MKs) in mammalian bone marrow (BM) by mechanisms that remain poorly understood. Here… (More)
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Highly Cited
2007
Highly Cited
2007
BACKGROUND The pathogenesis of chronic idiopathic thrombocytopenic purpura (ITP) involves antibody-mediated platelet destruction… (More)
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Highly Cited
2006
Highly Cited
2006
BACKGROUND Most current treatments for chronic immune thrombocytopenic purpura (ITP) act by decreasing platelet destruction. In a… (More)
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Highly Cited
2004
Highly Cited
2004
The molecular pathways involved in the differentiation of hematopoietic progenitors are unknown. Here we report that chemokine… (More)
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Highly Cited
2001
Highly Cited
2001
Baseline platelet production is dependent on thrombopoietin (TPO). TPO is constitutively produced and primarily regulated by… (More)
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Highly Cited
2000
Highly Cited
2000
A recent study in dogs suggested that erythropoietin (EPO) not only promotes the synthesis of increased numbers of reticulated… (More)
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Highly Cited
1994
Highly Cited
1994
Physiological platelet synthesis is thought to require the humoral activities of meg-CSF and thrombopoietin, which respectively… (More)
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Highly Cited
1994
Highly Cited
1994
The development of blood cells including expansion of megakaryocyte progenitor cells requires the interplay of marrow stromal… (More)
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1968
1968
Measurements of megakaryocyte number, volume, nuclear number, and cytoplasmic granulation were compared in animals with induced… (More)
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