Skip to search formSkip to main contentSkip to account menu

Thrombopoiesis

Known as: thrombocyte differentiation, Thrombocytopoiesis, platelet production 
The process of generating thrombocytes (BLOOD PLATELETS) from the pluripotent HEMATOPOIETIC STEM CELLS in the BONE MARROW via the MEGAKARYOCYTES. The… 
National Institutes of Health

Related topics

Related topics

15 relations
Blood CellsBlood PlateletsMPL geneMPL protein, human

Broader (1)

Hematopoiesis

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2013
Highly Cited
2013
PLATELETS AND THROMBOPOIESIS Defective tubulin organization and proplatelet formation in murine megakaryocytes lacking Rac 1 and Cdc 42
University of Würzburg, Department of Experimental Biomedicine, University Hospital and Rudolf Virchow Center, Deutsche… 
Review
2003
Review
2003
Platelet apoptosis in stored platelet concentrates and other models.
Highly Cited
2001
Highly Cited
2001
Thrombopoietin therapy increases platelet yields in healthy platelet donors.
The recombinant thrombopoietins have been shown to be effective stimulators of platelet production in cancer patients. It was… 
Highly Cited
1999
Highly Cited
1999
Thrombopoietin promotes hematopoietic recovery and survival after high-dose whole body irradiation.
Highly Cited
1999
Highly Cited
1999
The thrombocytopenia of Wiskott Aldrich syndrome is not related to a defect in proplatelet formation.
The Wiskott-Aldrich syndrome (WAS) is an X-linked hereditary disease characterized by thrombocytopenia with small platelet size… 
Highly Cited
1996
Highly Cited
1996
Constitutive expression of Mpl ligand transcripts during thrombocytopenia or thrombocytosis.
Mpl ligand (thrombopoietin [TPO]) is the physiological regulator of platelet production. In mice, mRNA encoding the Mpl ligand… 
Highly Cited
1984
Highly Cited
1984
Thrombocytopoiesis--analysis by membrane tracer and freeze-fracture studies on fresh human and cultured mouse megakaryocytes
The origin of platelets (Pt) from megakaryocytes (MK) is beyond question, but the mechanism whereby Pts are released from the… 
Highly Cited
1982
Highly Cited
1982
Evidence for a theory of physical fragmentation of megakaryocytes, implying that all platelets are produced in the pulmonary circulation.
Highly Cited
1977
Highly Cited
1977
Blood coagulation changes in mice bearing Lewis lung carcinoma, a metastasizing tumor.
In view of the possible role of platelets and coagulation mechanisms in the growth and dissemination of solid tumors, a number of… 
Highly Cited
1955
Highly Cited
1955
The dynamics of platelet production as studied by a depletion technique in normal and irradiated dogs.
By clicking accept or continuing to use the site, you agree to the terms outlined in our Privacy Policy (opens in a new tab), Terms of Service (opens in a new tab), and Dataset License (opens in a new tab)