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MPL gene

Known as: THROMBOPOIETIN RECEPTOR, MPL, MPLV 
This gene plays a regulatory role in megakaryocytopoiesis and platelet formation.
National Institutes of Health

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Related topics

13 relations
Cell ProliferationCytokine Signaling ProcessIntercellular Communication ProcessLigand Binding
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MPL wt Allele

Papers overview

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Highly Cited
2016
Highly Cited
2016
Targeted deep sequencing in polycythemia vera and essential thrombocythemia.
Polycythemia vera (PV) is characterized by JAK2 and essential thrombocythemia (ET) by JAK2, calreticulin (CALR), and… Expand
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Highly Cited
2014
Highly Cited
2014
Long-term survival and blast transformation in molecularly annotated essential thrombocythemia, polycythemia vera, and myelofibrosis.
Janus kinase 2 (JAK2) mutations define polycythemia vera (PV). Calreticulin (CALR) and myeloproliferative leukemia virus oncogene… Expand
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2014
2014
Mpl expression on megakaryocytes and platelets is dispensable for thrombopoiesis but essential to prevent myeloproliferation.
Thrombopoietin (TPO) acting via its receptor, the cellular homologue of the myeloproliferative leukemia virus oncogene (Mpl), is… Expand
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Highly Cited
2013
Highly Cited
2013
Acquired copy-neutral loss of heterozygosity of chromosome 1p as a molecular event associated with marrow fibrosis in MPL-mutated myeloproliferative neoplasms.
We studied mutations of MPL exon 10 in patients with essential thrombocythemia (ET) or primary myelofibrosis (PMF), first… Expand
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Highly Cited
2012
Highly Cited
2012
Imputation of exome sequence variants into population- based samples and blood-cell-trait-associated loci in African Americans: NHLBI GO Exome Sequencing Project.
Researchers have successfully applied exome sequencing to discover causal variants in selected individuals with familial, highly… Expand
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2011
2011
Effects of Clinically Relevant MPL Mutations in the Transmembrane Domain Revealed at the Atomic Level through Computational Modeling
BACKGROUND Mutations in the thrombopoietin receptor (MPL) may activate relevant pathways and lead to chronic myeloproliferative… Expand
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Highly Cited
2010
Highly Cited
2010
The JAK2 46/1 haplotype predisposes to MPL-mutated myeloproliferative neoplasms.
The 46/1 JAK2 haplotype predisposes to V617F-positive myeloproliferative neoplasms, but the underlying mechanism is obscure. We… Expand
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1994
1994
Structure and transcription of the human c-mpl gene (MPL).
The human c-mpl proto-oncogene encodes a member of the cytokine receptor superfamily, expressed mainly in CD 34-positive… Expand
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1993
1993
Characterization of the murine Mpl proto-oncogene, a member of the hematopoietic cytokine receptor family: molecular cloning, chromosomal location and evidence for a function in cell growth.
The v-mpl oncogene transduced in the myeloproliferative leukemia virus (MPLV) encodes a truncated form of a putative receptor… Expand
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Highly Cited
1990
Highly Cited
1990
A putative truncated cytokine receptor gene transduced by the myeloproliferative leukemia virus immortalizes hematopoietic progenitors
The myeloproliferative leukemia virus (MPLV) is an acute leukemogenic murine replication-defective retrovirus. By sequencing the… Expand
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