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MPL gene

Known as: THROMBOPOIETIN RECEPTOR, MPL, MPLV 
This gene plays a regulatory role in megakaryocytopoiesis and platelet formation.
National Institutes of Health

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Related topics

13 relations
Cell ProliferationCytokine Signaling ProcessIntercellular Communication ProcessLigand Binding

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MPL wt Allele

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2016
2016
Activation of Janus kinase/signal transducers and activators of transcription pathway involved in megakaryocyte proliferation induced by vanadium resembles some aspects of essential thrombocythemia
Vanadium (V) is an air pollutant released into the atmosphere by burning fossil fuels. Also, it has been recently evaluated for… 
2016
2016
Increased frequency of co-existing JAK2 exon-12 or MPL exon-10 mutations in patients with low JAK2V617F allelic burden
Abstract The frequency of co-existing JAK2V617F/MPL and JAK2V617F/JAK2 exon-12 mutations has not been previously investigated in… 
2011
2011
Effects of Clinically Relevant MPL Mutations in the Transmembrane Domain Revealed at the Atomic Level through Computational Modeling
Background Mutations in the thrombopoietin receptor (MPL) may activate relevant pathways and lead to chronic myeloproliferative… 
2009
2009
MPL W515L/K mutations in 343 Chinese adults with JAK2V617F mutation‐negative chronic myeloproliferative disorders detected by a newly developed RQ‐PCR based on TaqMan MGB probes
Acquired mutations in the juxtamembrane region of MPL (W515L or W515K), the receptor for thrombopoietin, have been reported in… 
2008
2008
Phospho-STAT5 expression pattern with the MPL W515L mutation is similar to that seen in chronic myeloproliferative disorders with JAK2 V617F.
2000
2000
Stem cell generation and choice of fate: role of cytokines and cellular microenvironment
Hematopoietic stem cells (HSC) have provided a model for the isolation, enrichment and transplantation of stem cells. Gene… 
Review
1995
Review
1995
c-mpl expression in hematologic disorders.
The c-mpl gene encodes a member of the hematopoietic cytokine receptor superfamily. This gene was discovered through the study of… 
1989
1989
Myeloid progenitor cells transformed by the myeloproliferative leukemia virus proliferate and differentiate in vitro without the addition of growth factors.
The myeloproliferative leukemia virus (MPLV) is an acute leukemogenic, nonsarcomatogenic replication-defective murine retrovirus… 
1989
1989
Factor-independent erythropoietic progenitor cells in leukemia induced by the myeloproliferative leukemia virus.
The myeloproliferative leukemia virus (MPLV), a novel murine retroviral complex that does not transform fibroblasts, has been… 
1987
1987
Genetic analysis of myeloproliferative leukemia virus, a novel acute leukemogenic replication-defective retrovirus
The myeloproliferative leukemia virus (MPLV) is a new acute leukemogenic, nonsarcomatogenic retroviral complex that is generated… 
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