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MPL gene
Known as:
THROMBOPOIETIN RECEPTOR
, MPL
, MPLV
Â
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This gene plays a regulatory role in megakaryocytopoiesis and platelet formation.
Topic mentions per year
Topic mentions per year
1971-2018
0
10
20
1971
2018
Related topics
Related topics
10 relations
Cell Proliferation
Cytokine Signaling Process
Intercellular Communication Process
Ligand Binding
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Narrower (1)
MPL wt Allele
Related mentions per year
Related mentions per year
1937-2018
1940
1960
1980
2000
2020
MPL gene
Cell Proliferation
Intercellular Communication Process
Thrombopoiesis
Receptor Signaling
Ligand Binding
Papers overview
Semantic Scholar uses AI to extract papers important to this topic.
2013
2013
The new psychology of reasoning: A mental probability logical perspective
N. Kleiter Pfeifer
2013
Mental probability logic (MPL) has been proposed as a competence theory of human inference. MPL interprets indicative…Â
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2011
2011
The role of the JAK2 GGCC haplotype and the TET2 gene in familial myeloproliferative neoplasms.
Damla Olcaydu
,
Elisa Rumi
,
+8 authors
Robert Kralovics
Haematologica
2011
BACKGROUND Myeloproliferative neoplasms constitute a group of diverse chronic myeloid malignancies that share pathogenic features…Â
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2010
2010
JAK2 and MPL gene mutations in V617F-negative myeloproliferative neoplasms.
Anna SiemiÄ…tkowska
,
Maria Bieniaszewska
,
Andrzej Rafal Hellmann
,
Janusz Limon
Leukemia research
2010
We report three novel mutations in JAK2 exons 12, 19 and 25 in V617F-negative patients with polycythemia vera, essential…Â
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2009
2009
Familial thrombocytosis caused by the novel germ-line mutation p.Pro106Leu in the MPL gene.
El-Harith Abdelghaffar El-Harith
,
Cornelia Roesl
,
+11 authors
Manfred Stuhrmann
British journal of haematology
2009
Familial thrombosis (FT) has been described as a rare autosomal-dominant disorder, mostly caused by activating mutations of the…Â
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2007
2007
Evidence for MPL W515L/K mutations in hematopoietic stem cells in primitive myelofibrosis.
Ronan Chaligné
,
Chloé James
,
+10 authors
Stéphane Giraudier
Blood
2007
The MPL (W515L and W515K) mutations have been detected in granulocytes of patients suffering from certain types of primitive…Â
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Highly Cited
2007
Highly Cited
2007
Critical role of thrombopoietin in maintaining adult quiescent hematopoietic stem cells.
Hong Qian
,
Natalija Buza-Vidas
,
+7 authors
Sten Eirik W Jacobsen
Cell stem cell
2007
The role of cytokines in regulation of hematopoietic stem cells (HSCs) remains poorly understood. Herein we demonstrate that…Â
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2005
2005
Low Mpl receptor expression in a pedigree with familial platelet disorder with predisposition to acute myelogenous leukemia and a novel AML1 mutation.
Paula Graciela Heller
,
Ana C. Glembotsky
,
+6 authors
Felisa Concepcion Molinas
Blood
2005
Germ-line heterozygous mutations in the hematopoietic transcription factor AML1 (RUNX1) have been identified in patients with…Â
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Highly Cited
2004
Highly Cited
2004
Familial essential thrombocythemia associated with a dominant-positive activating mutation of the c-MPL gene, which encodes for the receptor for thrombopoietin.
Jianmin Ding
,
Hirokazu Komatsu
,
+8 authors
Ryuzo Ueda
Blood
2004
One Japanese pedigree of familial essential thrombocythemia (FET) inherited in an autosomal-dominant manner is presented. A…Â
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1996
1996
Analysis of the thrombopoietin receptor (MPL) promoter implicates GATA and Ets proteins in the coregulation of megakaryocyte-specific genes.
Sophie Deveaux
,
A. Filipe
,
Valérie Lemarchandel
,
Jacques Ghysdael
,
P. H. Romeo
,
Vincent Mignotte
Blood
1996
The MPL gene codes for the thrombopoietin receptor, whose ligand specifically controls megakaryocytic differentiation. To…Â
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Highly Cited
1990
Highly Cited
1990
A putative truncated cytokine receptor gene transduced by the myeloproliferative leukemia virus immortalizes hematopoietic progenitors.
Michèle Souyri
,
Isabelle Vigon
,
J F Penciolelli
,
Jean Michel Heard
,
Pierre Tambourin
,
Françoise Wendling
Cell
1990
The myeloproliferative leukemia virus (MPLV) is an acute leukemogenic murine replication-defective retrovirus. By sequencing the…Â
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