FAQ

MPL gene

Known as: THROMBOPOIETIN RECEPTOR, MPL, MPLV 
This gene plays a regulatory role in megakaryocytopoiesis and platelet formation.

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Topic mentions per year

1971-2018
0102019712018

Related topics

Related topics

10 relations
Cell ProliferationCytokine Signaling ProcessIntercellular Communication ProcessLigand Binding
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MPL wt Allele

Related mentions per year

Related mentions per year

1937-2018
19401960198020002020
MPL gene
Cell Proliferation
Intercellular Communication Process
Thrombopoiesis
Receptor Signaling
Ligand Binding

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2013
2013
The new psychology of reasoning: A mental probability logical perspective
Mental probability logic (MPL) has been proposed as a competence theory of human inference. MPL interprets indicative… (More)
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2011
2011
The role of the JAK2 GGCC haplotype and the TET2 gene in familial myeloproliferative neoplasms.
BACKGROUND Myeloproliferative neoplasms constitute a group of diverse chronic myeloid malignancies that share pathogenic features… (More)
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2010
2010
JAK2 and MPL gene mutations in V617F-negative myeloproliferative neoplasms.
We report three novel mutations in JAK2 exons 12, 19 and 25 in V617F-negative patients with polycythemia vera, essential… (More)
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2009
2009
Familial thrombocytosis caused by the novel germ-line mutation p.Pro106Leu in the MPL gene.
Familial thrombosis (FT) has been described as a rare autosomal-dominant disorder, mostly caused by activating mutations of the… (More)
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2007
2007
Evidence for MPL W515L/K mutations in hematopoietic stem cells in primitive myelofibrosis.
The MPL (W515L and W515K) mutations have been detected in granulocytes of patients suffering from certain types of primitive… (More)
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Highly Cited
2007
Highly Cited
2007
Critical role of thrombopoietin in maintaining adult quiescent hematopoietic stem cells.
The role of cytokines in regulation of hematopoietic stem cells (HSCs) remains poorly understood. Herein we demonstrate that… (More)
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2005
2005
Low Mpl receptor expression in a pedigree with familial platelet disorder with predisposition to acute myelogenous leukemia and a novel AML1 mutation.
Germ-line heterozygous mutations in the hematopoietic transcription factor AML1 (RUNX1) have been identified in patients with… (More)
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Highly Cited
2004
Highly Cited
2004
Familial essential thrombocythemia associated with a dominant-positive activating mutation of the c-MPL gene, which encodes for the receptor for thrombopoietin.
One Japanese pedigree of familial essential thrombocythemia (FET) inherited in an autosomal-dominant manner is presented. A… (More)
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1996
1996
Analysis of the thrombopoietin receptor (MPL) promoter implicates GATA and Ets proteins in the coregulation of megakaryocyte-specific genes.
The MPL gene codes for the thrombopoietin receptor, whose ligand specifically controls megakaryocytic differentiation. To… (More)
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Highly Cited
1990
Highly Cited
1990
A putative truncated cytokine receptor gene transduced by the myeloproliferative leukemia virus immortalizes hematopoietic progenitors.
The myeloproliferative leukemia virus (MPLV) is an acute leukemogenic murine replication-defective retrovirus. By sequencing the… (More)
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