MPL protein, human

Known as: MPL ligand receptor, human, myeloproliferative leukemia virus oncogene protein, human, c-MPL Protein 
Thrombopoietin receptor (635 aa, ~71 kDa) is encoded by the human MPL gene. This protein plays a role in thrombopoietin signaling and the regulation… (More)
National Institutes of Health

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Highly Cited
2010
Highly Cited
2010
SUMMARY pegas (Population and Evolutionary Genetics Analysis System) is a new package for the analysis of population genetic data… (More)
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Highly Cited
2007
Highly Cited
2007
Maintenance of hematopoietic stem cells (HSCs) depends on interaction with their niche. Here we show that the long-term (LT)-HSCs… (More)
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Highly Cited
2006
Highly Cited
2006
Recently, a gain-of-function MPL mutation, MPLW515L, was described in patients with JAK2V617F-negative myelofibrosis with myeloid… (More)
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Highly Cited
1999
Highly Cited
1999
Congenital amegakaryocytic thrombocytopenia (CAMT) is a rare disorder expressed in infancy and characterized by isolated… (More)
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Highly Cited
1996
Highly Cited
1996
Mice with a null mutation in the thrombopoietin (TPO) receptor c-Mpl were generated by gene targeting. c-mpl-deficient mice… (More)
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Highly Cited
1994
Highly Cited
1994
Physiological platelet synthesis is thought to require the humoral activities of meg-CSF and thrombopoietin, which respectively… (More)
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Highly Cited
1994
Highly Cited
1994
THE development of blood cells including expansion of megakaryocyte progenitor cells requires the interplay of marrow stromal… (More)
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Highly Cited
1994
Highly Cited
1994
Thrombopoietin (TPO) is a cytokine that is involved in the regulation of platelet production. The receptor for TPO is c-Mpl. To… (More)
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Highly Cited
1994
Highly Cited
1994
A novel megakaryocyte growth and development factor (MGDF) has been identified in aplastic canine plasma, and its cDNAs have been… (More)
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Highly Cited
1992
Highly Cited
1992
We have cloned the human homolog of the v-mpl oncogene transduced in the myeloproliferative leukemia retrovirus, which presents… (More)
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