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MPL protein, human

Known as: MPL ligand receptor, human, myeloproliferative leukemia virus oncogene protein, human, c-MPL Protein 
Thrombopoietin receptor (635 aa, ~71 kDa) is encoded by the human MPL gene. This protein plays a role in thrombopoietin signaling and the regulation… 
National Institutes of Health

Related topics

Related topics

21 relations
Cell ProliferationCytokine Receptor GeneCytokine Signaling ProcessEltrombopag olamine

Broader (2)

Receptors, ImmunologicThrombopoietin Receptor

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2016
Highly Cited
2016
Calreticulin mutants in mice induce an MPL-dependent thrombocytosis with frequent progression to myelofibrosis.
Frameshift mutations in the calreticulin (CALR) gene are seen in about 30% of essential thrombocythemia and myelofibrosis… 
Highly Cited
2016
Highly Cited
2016
Mutant Calreticulin Requires Both Its Mutant C-terminus and the Thrombopoietin Receptor for Oncogenic Transformation.
UNLABELLED Somatic mutations in calreticulin (CALR) are present in approximately 40% of patients with myeloproliferative… 
Highly Cited
2013
Highly Cited
2013
Supramolecular photosensitizers with enhanced antibacterial efficiency.
Highly Cited
2006
Highly Cited
2006
MOZ is essential for maintenance of hematopoietic stem cells.
Monocytic leukemia zinc-finger protein (MOZ), a MYST family histone acetyltransferase, is involved in the chromosome… 
Highly Cited
2004
Highly Cited
2004
Lnk Inhibits Tpo–mpl Signaling and Tpo-mediated Megakaryocytopoiesis
Thrombopoietin (Tpo) is the primary cytokine regulating megakaryocyte development and platelet production. Tpo signaling through… 
Highly Cited
1999
Highly Cited
1999
Thrombopoietin-induced activation of the mitogen-activated protein kinase (MAPK) pathway in normal megakaryocytes: role in endomitosis.
Thrombopoietin (TPO) plays a critical role in megakaryocyte proliferation and differentiation. Using various cultured cell lines… 
Highly Cited
1999
Highly Cited
1999
Gab-family adapter proteins act downstream of cytokine and growth factor receptors and T- and B-cell antigen receptors.
We previously found that the adapter protein Gab1 (110 kD) is tyrosine-phosphorylated and forms a complex with SHP-2 and PI-3… 
Highly Cited
1997
Highly Cited
1997
Thrombopoietin signal transduction in purified murine megakaryocytes.
Thrombopoietin (TPO) is a recently cloned cytokine that binds to its receptor, Mpl, and promotes hematopoietic expansion and… 
Highly Cited
1995
Highly Cited
1995
Purification and characterization of thrombopoietin.
A thrombopoietic factor, termed thrombopoietin (TPO), was highly purified directly from the plasma of sublethally irradiated 1… 
Highly Cited
1947
Highly Cited
1947
DISEASE
Background: Little is known about patients who frequently visit the emergency department (ED) for acute exacerbation of chronic… 
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