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MPL protein, human

Known as: MPL ligand receptor, human, myeloproliferative leukemia virus oncogene protein, human, c-MPL Protein 
Thrombopoietin receptor (635 aa, ~71 kDa) is encoded by the human MPL gene. This protein plays a role in thrombopoietin signaling and the regulation… 
National Institutes of Health

Related topics

Related topics

21 relations
Cell ProliferationCytokine Receptor GeneCytokine Signaling ProcessEltrombopag olamine

Broader (2)

Receptors, ImmunologicThrombopoietin Receptor

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2009
Highly Cited
2009
Incomplete restoration of Mpl expression in the mpl-/- mouse produces partial correction of the stem cell-repopulating defect and paradoxical thrombocytosis.
Expression of Mpl is restricted to hematopoietic cells in the megakaryocyte lineage and to undifferentiated progenitors, where it… 
Highly Cited
2008
Highly Cited
2008
New mutations of MPL in primitive myelofibrosis: only the MPL W515 mutations promote a G1/S-phase transition
MPL (or thrombopoietin receptor, TPO-R) 515 mutations have recently been described in 5–10% of primitive myelofibrosis (PMF… 
Highly Cited
1998
Highly Cited
1998
Targeted expansion of genetically modified bone marrow cells.
The ability to specifically target a mitogenic signal to a population of genetically modified primary cells would have potential… 
Highly Cited
1997
Highly Cited
1997
Defective response to thrombopoietin and impaired expression of c‐mpl mRNA of bone marrow cells in congenital amegakaryocytic thrombocytopenia
Congenital amegakaryocytic thrombocytopenia (CAMT) is an uncommon disorder in newborns and infants, characterized by isolated… 
Highly Cited
1996
Highly Cited
1996
Functional regions of the mouse thrombopoietin receptor cytoplasmic domain: evidence for a critical region which is involved in differentiation and can be complemented by erythropoietin
Thrombopoietin (TPO) is the major regulator of growth and differentiation of megakaryocytes. To identify functionally important… 
Highly Cited
1996
Highly Cited
1996
Bone marrow stromal cells produce thrombopoietin and stimulate megakaryocyte growth and maturation but suppress proplatelet formation.
Production of blood cells is regulated by the interplay of various cytokines and bone marrow stromal cells. Recently, a ligand… 
Highly Cited
1996
Highly Cited
1996
Constitutive expression of Mpl ligand transcripts during thrombocytopenia or thrombocytosis.
Mpl ligand (thrombopoietin [TPO]) is the physiological regulator of platelet production. In mice, mRNA encoding the Mpl ligand… 
Highly Cited
1995
Highly Cited
1995
Recombinant human megakaryocyte growth and development factor (rhumgdf), a ligand for c‐mpl, produces functional human platelets in vitro
Platelet formation, occurring from bone marrow or lung megakaryocytes, has been difficult to study mechanistically. Recombinant… 
Highly Cited
1978
Highly Cited
1978
Relationship between oxygen uptake of perifused rat-liver cells and the cytosolic phosphorylation state calculated from indicator metabolites and a redetermined equilibrium constant.
1. The relationship between the rate of oxygen uptake in isolated rat-liver cells and the cytosolic phosphorylation state was… 
Highly Cited
1947
Highly Cited
1947
DISEASE
Background: Little is known about patients who frequently visit the emergency department (ED) for acute exacerbation of chronic… 
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