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Thrombopoietin Receptor

Known as: Thrombopoietin Receptors, Antigens, CD110, Receptors, Thrombopoietin [Chemical/Ingredient] 
Cell surface receptors that are specific for THROMBOPOIETIN. They contain two central FIBRONECTIN TYPE III DOMAINS and signal through interaction… 
National Institutes of Health

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In BloodMPL geneagonistsantagonists & inhibitors

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MPL protein, human

Papers overview

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Highly Cited
2011
Highly Cited
2011
Orientation‐specific signalling by thrombopoietin receptor dimers
Ligand binding to the thrombopoietin receptor is thought to stabilize an active receptor dimer that regulates megakaryocyte… 
2011
2011
Eltrombopag for the treatment of immune thrombocytopenia
Chronic immune thrombocytopenia (ITP) is an autoimmune disorder characterized by a low platelet count that has persisted for more… 
2004
2004
Effects of SB559457, a Novel Small Molecule Thrombopoietin Receptor (TpoR) Agonist, on Human Hematopoietic Cell Growth and Differentiation.
Treatment of thrombocytopenia resulting from chemotherapy, radiation, or stem cell transplantation remains problematic. Hopes… 
2003
2003
Anti-c-Mpl (thrombopoietin receptor) autoantibody-induced amegakaryocytic thrombocytopenia in a patient with systemic sclerosis.
Amegakaryocytic thrombocytopenia (AMT) associated with systemic sclerosis (SSc) has been described in several case reports, but… 
Highly Cited
2002
Highly Cited
2002
Identification of a pharmacophore for thrombopoietic activity of small, non-peptidyl molecules. 2. Rational design of naphtho[1,2-d]imidazole thrombopoietin mimics.
The invention of a new class of naphtho[1,2-d]imidazole thrombopoietin mimics based on a pharmacophore hypothesis for small… 
2002
2002
Human plasma thrombopoietin levels are regulated by binding to platelet thrombopoietin receptors in vivo
BACKGROUND: Data from several studies support the hypothesis that thrombopoietin (TPO) plasma levels are regulated via… 
2002
2002
Circulating Thrombopoietin in Clonal Versus Reactive Thrombocytosis
Introduction: The aim of this study is to assess circulating thrombopoietin concentrations in patients with both clonal and… 
1998
1998
Quantitative analysis of thrombopoietin receptors on human megakaryocytes
Highly Cited
1996
Highly Cited
1996
A model of myelofibrosis and osteosclerosis in mice induced by overexpressing thrombopoietin (mpl ligand): reversal of disease by bone marrow transplantation.
We have previously shown that mice induced to overexpress thrombopoietin (TPO) by retroviral-mediated gene transfer into bone… 
1978
1978
Neutralizing Antiserum to Thrombopoietin 1
  • T. McDonald
  • Proceedings of the Society for Experimental…
  • 1978
  • Corpus ID: 42441168
Summary Potent thrombopoietin (TSF) materials were mixed with normal rabbit serum and serum from rabbits that had been immunized… 
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