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Thromboplastin

Known as: Factor III, Coagulation, factors tissue, Procoagulant, Tissue Factor 
Constituent composed of protein and phospholipid that is widely distributed in many tissues. It serves as a cofactor with factor VIIa to activate… 
National Institutes of Health

Related topics

Related topics

21 relations
Activated Partial Thromboplastin Time measurementCoagulantsF3 geneFactor Xa

Broader (2)

Blood Coagulation FactorHemostatic Agents

Narrower (5)

InnovinThrombofaxTissue Factorendothelial cell procoagulant activity

Papers overview

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Highly Cited
2009
Highly Cited
2009
Cancer cell–derived microparticles bearing P-selectin glycoprotein ligand 1 accelerate thrombus formation in vivo
Recent publications have demonstrated the presence of tissue factor (TF)–bearing microparticles (MPs) in the blood of patients… 
Review
2005
Review
2005
The P‐selectin, tissue factor, coagulation triad
Summary.  The primary importance of tissue factor (TF) in blood coagulation and thrombus propagation has been recognized for many… 
Highly Cited
2004
Highly Cited
2004
Endothelial cell apoptosis in systemic lupus erythematosus: a common pathway for abnormal vascular function and thrombosis propensity.
Women with systemic lupus erythematosus (SLE) are at risk for premature atherothrombosis independent of Framingham risk factors… 
Highly Cited
2003
Highly Cited
2003
The effect of temperature and pH on the activity of factor VIIa: implications for the efficacy of high-dose factor VIIa in hypothermic and acidotic patients.
BACKGROUND Recombinant coagulation factor VIIa (FVIIa) is approved for treating hemophiliacs with inhibitors. High-dose FVIIa has… 
Highly Cited
1996
Highly Cited
1996
Edema from intracerebral hemorrhage: the role of thrombin.
The mechanism by which intracerebral hemorrhage leads to the formation of brain edema is unknown. This study assesses the… 
Highly Cited
1991
Highly Cited
1991
Comparison of anticoagulant and procoagulant activities of stimulated platelets and platelet-derived microparticles.
Activation of human platelets considerably enhanced their ability to accelerate factor Va inactivation by activated protein C… 
Highly Cited
1990
Highly Cited
1990
Complement proteins C5b-9 induce vesiculation of the endothelial plasma membrane and expose catalytic surface for assembly of the prothrombinase enzyme complex.
Highly Cited
1989
Highly Cited
1989
Assembly of the platelet prothrombinase complex is linked to vesiculation of the platelet plasma membrane. Studies in Scott syndrome: an isolated defect in platelet procoagulant activity.
Highly Cited
1988
Highly Cited
1988
Complement proteins C5b-9 cause release of membrane vesicles from the platelet surface that are enriched in the membrane receptor for coagulation factor Va and express prothrombinase activity.
We have investigated the composition and function of membrane microparticles released from platelets exposed to the C5b-9… 
Highly Cited
1986
Highly Cited
1986
Modulation of endothelial cell hemostatic properties by tumor necrosis factor
Tumor necrosis factor/cachectin (TNF) is a mediator of the septic state, which involves diffuse abnormalities of coagulation… 
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