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Factor Xa

Known as: Xa, Coagulation Factor, prothrombase, Factor Xa [Chemical/Ingredient] 
Activated form of factor X that participates in both the intrinsic and extrinsic pathways of blood coagulation. It catalyzes the conversion of… 
National Institutes of Health

Related topics

Related topics

16 relations
CoagulantsProcess of secretionThromboplastinagonists

Narrower (5)

Factor Xa, des(1-45)-PRT064445dansyl-glutamyl-glycyl-arginyl chloromethyl ketone-treated factor Xaglutamyl-glycyl-arginyl chloromethyl ketone inactivated human factor Xa

Broader (1)

factor X

Papers overview

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Highly Cited
2010
Highly Cited
2010
Cardiovascular , Pulmonary and Renal Pathology Factor Xa Stimulates Proinflammatory and Profibrotic Responses in Fibroblasts via Protease-Activated Receptor-2 Activation
Coagulation proteases have been suggested to play a role in the pathogenesis of tissue remodeling and fibrosis. We therefore… 
Highly Cited
2009
Highly Cited
2009
Is thrombin generation the new rapid, reliable and relevant pharmacological tool for the development of anticoagulant drugs?
Highly Cited
2001
Highly Cited
2001
Discovery of 1-[3-(aminomethyl)phenyl]-N-3-fluoro-2'-(methylsulfonyl)-[1,1'-biphenyl]-4-yl]-3-(trifluoromethyl)-1H-pyrazole-5-carboxamide (DPC423), a highly potent, selective, and orally bioavailable…
Factor Xa (fXa) plays a critical role in the coagulation cascade, serving as the point of convergence of the intrinsic and… 
Highly Cited
2001
Highly Cited
2001
Prothrombin protects factor Xa in the prothrombinase complex from inhibition by the heparin-antithrombin complex.
Heparin is a commonly used anticoagulant drug. It functions primarily by accelerating the antithrombin inhibition of coagulation… 
Review
2001
Review
2001
Perspectives on factor Xa inhibition.
Blood coagulation involves a complex cascade of enzymatic reactions, ultimately generating fibrin, the basis of all blood clots… 
Highly Cited
1998
Highly Cited
1998
Structural and functional analyses of benzamidine-based inhibitors in complex with trypsin: implications for the inhibition of factor Xa, tPA, and urokinase.
The trypsin-like serine proteinase superfamily contains a number of potential therapeutic targets, many of which are unsuitable… 
Highly Cited
1991
Highly Cited
1991
Monitoring of coagulation status using thrombelastography during paediatric open heart surgery
Thrombelastography (TEG) has proved useful in identifying coagulopathies (via assessment of clot elasticity properties) during… 
Highly Cited
1976
Highly Cited
1976
Antifactor Xa activity measured with amidolytic methods.
Methods for the assay of antifactor Xa activity in the presence and absence of heparin are described. Diluted plasma is incubated… 
Highly Cited
1972
Highly Cited
1972
Mechanism of bovine prothrombin activation by an insoluble preparation of bovine factor X a (thrombokinase).
Highly Cited
1969
Highly Cited
1969
Biological activities of leupeptins.
Leupeptins, leupeptin Pr and leupeptin Ac, strongly inhibit proteolysis by plasmin, trypsin and papain, but do not inhibit… 
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