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Translational resistance of late alphavirus mRNA to eIF2alpha phosphorylation: a strategy to overcome the antiviral effect of protein kinase PKR.
- I. Ventoso, M. A. Sanz, S. Molina, J. Berlanga, Luis Carrasco, M. Esteban
- Biology, Computer ScienceGenes & development
The double-stranded RNA-dependent protein kinase (PKR) is one of the four mammalian kinases that phosphorylates the translation initiation factor 2alpha in response to virus infection. This kinase is…
Viroporins: structure and biological functions
This work reviews recent studies in the field that have advanced the knowledge of the structure and function of this expanding family of viral proteins and identifies several compounds that block their pore-forming activity.
Insights into the High-energy gamma-ray emission of Markarian 501 from extensive multifrequency observations in the Fermi Era
We report on the gamma-ray activity of the blazar Mrk 501 during the first 480 days of Fermi operation. We find that the average LAT gamma-ray spectrum of Mrk 501 can be well described by a single…
Antiviral effect of the mammalian translation initiation factor 2α kinase GCN2 against RNA viruses
It is determined that GCN2 inhibits SV replication by blocking early viral translation of genomic SV RNA and point to a hitherto unrecognized role ofGCN2 as an early mediator in the cellular response to RNA viruses.
Modification of Membrane Permeability by Animal Viruses
Effects of a 10-week in-season eccentric-overload training program on muscle-injury prevention and performance in junior elite soccer players.
- M. de Hoyo, M. Pozzo, Eduardo Morán-Camacho
- EducationInternational journal of sports physiology and…
The eccentric-based program led to a reduction in muscle-injury incidence and severity and showed improvements in common soccer tasks such as jumping ability and linear-sprinting speed.
EXPLORING THE BLAZAR ZONE IN HIGH-ENERGY FLARES OF FSRQs
The gamma-ray emission offers a powerful diagnostic tool to probe jets and their surroundings in flat-spectrum radio quasars (FSRQs). In particular, sources emitting at high energies (>10 GeV) give…
Poliovirus protein 2C has ATPase and GTPase activities.
Flare-like Variability of the Mg II λ2800 Emission Line in the Γ-Ray Blazar 3C 454.3
We report the detection of a statistically significant flare-like event in the Mg II λ2800 emission line of 3C 454.3 during the outburst of autumn 2010. The highest levels of emission line flux…
MOLECULAR GAS, KINEMATICS, AND OB STAR FORMATION IN THE SPIRAL ARMS OF THE SOUTHERN MILKY WAY
The rotation curve for the fourth Galactic quadrant within the solar circle is derived from the Columbia University-Universidad de Chile CO (J = 1 → 0) survey of molecular gas. A new sampling, 4…