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Thiopurine S-Methyltransferase

Known as: EC 2.1.1.67, TPMT, S-adenosyl-L-methionine thiopurine S-methyltransferase 
Thiopurine S-methyltransferase (245 aa, ~28 kDa) is encoded by the human TPMT gene. This protein is involved in the metabolism of xenobiotics.
National Institutes of Health

Related topics

Related topics

12 relations
AzathioprineEnzyme GeneMethylationMethyltransferase Gene

Broader (1)

Methyltransferase

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Review
2009
Review
2009
The Increasing Complexity of Mercaptopurine Pharmacogenomics
Thiopurine methyltransferase (TPMT) activity shows significant interindividual variation, with approximately 90% of individuals… 
2007
2007
Pancytopenia due to high 6-methylmercaptopurine levels in a 6-mercaptopurine treated patient with Crohn's disease.
2005
2005
The Impact of Thiopurine S-Methyltransferase Polymorphism on Azathioprine-Induced Myelotoxicity in Renal Transplant Recipients
Thiopurine S-methyltransferase (TPMT) is an enzyme that catalyzes the S-methylation of thiopurine drugs such as 6-mercaptopurine… 
2004
2004
INHIBITION OF TRANS-PERMETHRIN HYDROLYSIS IN HUMAN LIVER FRACTIONS BY CHLOROPYRIFOS OXON AND CARBARYL
Permethrin, a pyrethroid insecticide, is one of several deployment-related chemicals that have been suggested as causative agents… 
2003
2003
Phenotypic and Genotypic Analysis of Thiopurine S‐Methyltransferase Polymorphism in the Bulgarian Population
&NA; Genetic polymorphism of TPMT activity is an important factor responsible for large individual differences in thiopurine… 
Highly Cited
2003
Highly Cited
2003
A novel TPMT missense mutation associated with TPMT deficiency in a 5-year-old boy with ALL
A novel TPMT missense mutation associated with TPMT deficiency in a 5-year-old boy with ALL 
2002
2002
Thiopurine methyltransferase activity: new conditions for reversed-phase high-performance liquid chromatographic assay without extraction and genotypic-phenotypic correlation.
Highly Cited
2001
Highly Cited
2001
Differing contribution of thiopurine methyltransferase to mercaptopurine versus thioguanine effects in human leukemic cells.
Thioguanine and mercaptopurine are prodrugs requiring conversion into thiopurine nucleotides to exert cytotoxicity. Thiopurine S… 
2001
2001
Thiopurine methyltransferase activity in the Jewish population of Israel
Abstract. Objective: 6-Mercaptopurine is used therapeutically for its immunosuppressant and cytotoxic properties. It is… 
2000
2000
Frequency of thiopurine S-methyltransferase genetic variation in Thai children with acute leukemia.
BACKGROUND Thiopurine S-methyltransferase (TPMT) catalyzes the S-methylation (inactivation) of mercaptopurine, azathioprine, and… 
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