Thiopurine S-Methyltransferase

Known as: EC 2.1.1.67, TPMT, S-adenosyl-L-methionine thiopurine S-methyltransferase 
Thiopurine S-methyltransferase (245 aa, ~28 kDa) is encoded by the human TPMT gene. This protein is involved in the metabolism of xenobiotics.
National Institutes of Health

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AzathioprineEnzyme GeneMethylationMethyltransferase Gene
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Methyltransferase

Papers overview

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Highly Cited
2011
Highly Cited
2011
Clinical Pharmacogenetics Implementation Consortium guidelines for thiopurine methyltransferase genotype and thiopurine dosing.
Thiopurine methyltransferase (TPMT) activity exhibits monogenic co-dominant inheritance, with ethnic differences in the frequency… (More)
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Highly Cited
2005
Highly Cited
2005
Thiopurine S-methyltransferase pharmacogenetics: variant allele functional and comparative genomics.
Thiopurine S-methyltransferase (TPMT) catalyses the S-methylation of thiopurine drugs. Genetic polymorphisms for TPMT are a major… (More)
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Highly Cited
2005
Highly Cited
2005
Thiopurine methyltransferase (TPMT) genotype and early treatment response to mercaptopurine in childhood acute lymphoblastic leukemia.
CONTEXT Early response to multiagent chemotherapy, including mercaptopurine, as measured by minimal residual disease is an… (More)
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2003
2003
Thiopurine S-methyltransferase pharmacogenetics: chaperone protein association and allozyme degradation.
Thiopurine S-methyltransferase (TPMT) catalyses the S-methylation of thiopurine drugs such as 6-mercaptopurine. A common genetic… (More)
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Review
2002
Review
2002
The thiopurine S-methyltransferase gene locus -- implications for clinical pharmacogenomics.
Thiopurine methyltransferase catalyzes the S-methylation of azathioprine (AZA), 6-mercapto-purine (6-MP) and thioguanine… (More)
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Highly Cited
1999
Highly Cited
1999
Polymorphism of the thiopurine S-methyltransferase gene in African-Americans.
The molecular basis for the genetic polymorphism of thiopurine S -methyltransferase (TPMT) has been estab-lished for Caucasians… (More)
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Highly Cited
1997
Highly Cited
1997
Enhanced proteolysis of thiopurine S-methyltransferase (TPMT) encoded by mutant alleles in humans (TPMT*3A, TPMT*2): mechanisms for the genetic polymorphism of TPMT activity.
TPMT is a cytosolic enzyme that catalyzes the S-methylation of aromatic and heterocyclic sulfhydryl compounds, including… (More)
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Review
1996
Review
1996
Genetic polymorphism of thiopurine S-methyltransferase: clinical importance and molecular mechanisms.
Thiopurine S-methyltransferase (TPMT) catalyses the S-methylation of thiopurines such as mercaptopurine and thioguanine. TPMT… (More)
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Highly Cited
1995
Highly Cited
1995
A single point mutation leading to loss of catalytic activity in human thiopurine S-methyltransferase.
Thiopurine S-methyltransferase (TPMT; S-adenosyl-L-methionine:thiopurine S-methyltransferase, EC 2.1.1.67) activity exhibits… (More)
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Highly Cited
1995
Highly Cited
1995
Sulphasalazine inhibition of thiopurine methyltransferase: possible mechanism for interaction with 6-mercaptopurine and azathioprine.
Thiopurine drugs are used in the treatment of inflammatory bowel disease--as are sulphasalazine and its metabolite 5… (More)
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