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Thiopurine S-Methyltransferase

Known as: EC 2.1.1.67, TPMT, S-adenosyl-L-methionine thiopurine S-methyltransferase 
Thiopurine S-methyltransferase (245 aa, ~28 kDa) is encoded by the human TPMT gene. This protein is involved in the metabolism of xenobiotics.
National Institutes of Health

Papers overview

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Review
2009
Review
2009
Thiopurine methyltransferase (TPMT) activity shows significant interindividual variation, with approximately 90% of individuals… 
2005
2005
Thiopurine S-methyltransferase (TPMT) is an enzyme that catalyzes the S-methylation of thiopurine drugs such as 6-mercaptopurine… 
2004
2004
Permethrin, a pyrethroid insecticide, is one of several deployment-related chemicals that have been suggested as causative agents… 
2003
2003
&NA; Genetic polymorphism of TPMT activity is an important factor responsible for large individual differences in thiopurine… 
Highly Cited
2003
Highly Cited
2003
A novel TPMT missense mutation associated with TPMT deficiency in a 5-year-old boy with ALL 
Highly Cited
2001
Highly Cited
2001
Thioguanine and mercaptopurine are prodrugs requiring conversion into thiopurine nucleotides to exert cytotoxicity. Thiopurine S… 
2001
2001
Abstract. Objective: 6-Mercaptopurine is used therapeutically for its immunosuppressant and cytotoxic properties. It is… 
2000
2000
BACKGROUND Thiopurine S-methyltransferase (TPMT) catalyzes the S-methylation (inactivation) of mercaptopurine, azathioprine, and…