Thiopurine S-Methyltransferase

Known as: EC 2.1.1.67, TPMT, S-adenosyl-L-methionine thiopurine S-methyltransferase 
Thiopurine S-methyltransferase (245 aa, ~28 kDa) is encoded by the human TPMT gene. This protein is involved in the metabolism of xenobiotics.
National Institutes of Health

Papers overview

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Highly Cited
2011
Highly Cited
2011
Thiopurine methyltransferase (TPMT) activity exhibits monogenic co-dominant inheritance, with ethnic differences in the frequency… (More)
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Highly Cited
2005
Highly Cited
2005
Thiopurine S-methyltransferase (TPMT) catalyses the S-methylation of thiopurine drugs. Genetic polymorphisms for TPMT are a major… (More)
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Highly Cited
2005
Highly Cited
2005
CONTEXT Early response to multiagent chemotherapy, including mercaptopurine, as measured by minimal residual disease is an… (More)
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2003
2003
Thiopurine S-methyltransferase (TPMT) catalyses the S-methylation of thiopurine drugs such as 6-mercaptopurine. A common genetic… (More)
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Review
2002
Review
2002
Thiopurine methyltransferase catalyzes the S-methylation of azathioprine (AZA), 6-mercapto-purine (6-MP) and thioguanine… (More)
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Highly Cited
1999
Highly Cited
1999
The molecular basis for the genetic polymorphism of thiopurine S -methyltransferase (TPMT) has been estab-lished for Caucasians… (More)
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Highly Cited
1997
Highly Cited
1997
TPMT is a cytosolic enzyme that catalyzes the S-methylation of aromatic and heterocyclic sulfhydryl compounds, including… (More)
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Review
1996
Review
1996
Thiopurine S-methyltransferase (TPMT) catalyses the S-methylation of thiopurines such as mercaptopurine and thioguanine. TPMT… (More)
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Highly Cited
1995
Highly Cited
1995
Thiopurine S-methyltransferase (TPMT; S-adenosyl-L-methionine:thiopurine S-methyltransferase, EC 2.1.1.67) activity exhibits… (More)
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Highly Cited
1995
Highly Cited
1995
Thiopurine drugs are used in the treatment of inflammatory bowel disease--as are sulphasalazine and its metabolite 5… (More)
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