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Thiopurine S-Methyltransferase
Known as:
EC 2.1.1.67
, TPMT
, S-adenosyl-L-methionine thiopurine S-methyltransferase
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Thiopurine S-methyltransferase (245 aa, ~28 kDa) is encoded by the human TPMT gene. This protein is involved in the metabolism of xenobiotics.
National Institutes of Health
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Related topics
Related topics
12 relations
Azathioprine
Enzyme Gene
Methylation
Methyltransferase Gene
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Broader (1)
Methyltransferase
Papers overview
Semantic Scholar uses AI to extract papers important to this topic.
Review
2009
Review
2009
The Increasing Complexity of Mercaptopurine Pharmacogenomics
S. Marsh
,
D. V. van Booven
Clinical pharmacology and therapy
2009
Corpus ID: 41036385
Thiopurine methyltransferase (TPMT) activity shows significant interindividual variation, with approximately 90% of individuals…
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2007
2007
Pancytopenia due to high 6-methylmercaptopurine levels in a 6-mercaptopurine treated patient with Crohn's disease.
L. Gilissen
,
L. Derijks
,
+4 authors
L. Engels
Digestive and Liver Disease
2007
Corpus ID: 10107096
2005
2005
The Impact of Thiopurine S-Methyltransferase Polymorphism on Azathioprine-Induced Myelotoxicity in Renal Transplant Recipients
M. Kurzawski
,
K. Dziewanowski
,
B. Gawrońska-Szklarz
,
L. Domański
,
M. Droździk
Therapeutic Drug Monitoring
2005
Corpus ID: 8428052
Thiopurine S-methyltransferase (TPMT) is an enzyme that catalyzes the S-methylation of thiopurine drugs such as 6-mercaptopurine…
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2004
2004
INHIBITION OF TRANS-PERMETHRIN HYDROLYSIS IN HUMAN LIVER FRACTIONS BY CHLOROPYRIFOS OXON AND CARBARYL
Jonghoon Choi
,
E. Hodgson
,
R. Rose
Drug Metabolism and Drug Interactions
2004
Corpus ID: 23972604
Permethrin, a pyrethroid insecticide, is one of several deployment-related chemicals that have been suggested as causative agents…
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2003
2003
Phenotypic and Genotypic Analysis of Thiopurine S‐Methyltransferase Polymorphism in the Bulgarian Population
Dessislava Indjova
,
S. Atanasova
,
M. Shipkova
,
V. Armstrong
,
M. Oellerich
,
D. Svinarov
Therapeutic Drug Monitoring
2003
Corpus ID: 1050432
&NA; Genetic polymorphism of TPMT activity is an important factor responsible for large individual differences in thiopurine…
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Highly Cited
2003
Highly Cited
2003
A novel TPMT missense mutation associated with TPMT deficiency in a 5-year-old boy with ALL
E. Schaeffeler
,
M. Stanulla
,
+4 authors
M. Schwab
Leukemia
2003
Corpus ID: 33747918
A novel TPMT missense mutation associated with TPMT deficiency in a 5-year-old boy with ALL
2002
2002
Thiopurine methyltransferase activity: new conditions for reversed-phase high-performance liquid chromatographic assay without extraction and genotypic-phenotypic correlation.
D. Anglicheau
,
S. Sanquer
,
M. Loriot
,
P. Beaune
,
E. Thervet
Journal of chromatography. B, Analytical…
2002
Corpus ID: 40445513
Highly Cited
2001
Highly Cited
2001
Differing contribution of thiopurine methyltransferase to mercaptopurine versus thioguanine effects in human leukemic cells.
Thierry Dervieux
,
J. Blanco
,
E. Krynetski
,
E. Vanin
,
M. Roussel
,
M. Relling
Cancer Research
2001
Corpus ID: 14445879
Thioguanine and mercaptopurine are prodrugs requiring conversion into thiopurine nucleotides to exert cytotoxicity. Thiopurine S…
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2001
2001
Thiopurine methyltransferase activity in the Jewish population of Israel
A. Lowenthal
,
N. Meyerstein
,
Z. Ben‐Zvi
European Journal of Clinical Pharmacology
2001
Corpus ID: 38240051
Abstract. Objective: 6-Mercaptopurine is used therapeutically for its immunosuppressant and cytotoxic properties. It is…
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2000
2000
Frequency of thiopurine S-methyltransferase genetic variation in Thai children with acute leukemia.
S. Hongeng
,
W. Sasanakul
,
A. Chuansumrit
,
S. Pakakasama
,
Apisit Chattananon
,
Phongjan Hathirat
Medical and Pediatric Oncology
2000
Corpus ID: 41455155
BACKGROUND Thiopurine S-methyltransferase (TPMT) catalyzes the S-methylation (inactivation) of mercaptopurine, azathioprine, and…
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