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Metabolism of chlorpyrifos by human cytochrome P450 isoforms and human, mouse, and rat liver microsomes.
  • J. Tang, Y. Cao, +4 authors E. Hodgson
  • Biology, Medicine
  • Drug metabolism and disposition: the biological…
  • 1 September 2001
One of the factors determining the toxicity of chlorpyrifos (CPS), an organophosphorus (OP) insecticide, is its biotransformation. CPS can be activated by cytochrome P450 (CYP) through aExpand
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Identification of variants of CYP3A4 and characterization of their abilities to metabolize testosterone and chlorpyrifos.
CYP3A4 is the most abundant isoform of cytochrome P450 (CYP) in adult human liver. It metabolizes numerous clinically, physiologically, and toxicologically important compounds. The expression ofExpand
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Insect Cytochrome P450
Cytochrome P450 (P450) dependent monooxygenase systems occur in most if not all organisms, from bacteria to mammals and higher plants. In insects, the biochemical functions ascribed to this enzymeExpand
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In vitro metabolism of carbaryl by human cytochrome P450 and its inhibition by chlorpyrifos.
Carbaryl is a widely used anticholinesterase carbamate insecticide. Although previous studies have demonstrated that carbaryl can be metabolized by cytochrome P450 (CYP), the identification andExpand
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Fipronil induces CYP isoforms and cytotoxicity in human hepatocytes.
Recent studies have demonstrated the potential of pesticides to either inhibit or induce xenobiotic metabolizing enzymes in humans. Exposure of human hepatocytes to doses of fipronilExpand
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In vitro metabolism of fipronil by human and rat cytochrome P450 and its interactions with testosterone and diazepam.
Fipronil (5-amino-1-[2,6-dichloro-4-(trifluoromethyl)phenyl]-4-[(trifluoromethyl)sulfinyl]-1H-pyrazole-3-carbonitrile) is a highly active, broad spectrum insecticide from the phenyl pyrazole family,Expand
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In vitro human metabolism of permethrin: the role of human alcohol and aldehyde dehydrogenases
Permethrin is a pyrethroid insecticide widely used in agriculture and public health. It has been suggested that permethrin may interact with other chemicals used during military deployments and, as aExpand
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In vitro sulfoxidation of thioether compounds by human cytochrome P450 and flavin-containing monooxygenase isoforms with particular reference to the CYP2C subfamily.
Cytochrome P450 (P450) and flavin-containing monooxygenase (FMO) enzymes are major catalysts involved in the metabolism of xenobiotics. The sulfoxidation of the thioether pesticides, phorate,Expand
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Comparative metabolism of chloroacetamide herbicides and selected metabolites in human and rat liver microsomes.
Acetochlor [2-chloro-N-(ethoxymethyl)-N-(2-ethyl-6-methyl-phenyl)-acetamide], alachlor [N-(methoxymethyl)-2-chloro-N-(2, 6-diethyl-phenyl)acetamide], butachlorExpand
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Cytochrome P450-associated insecticide resistance and the development of biochemical diagnostic assays in Heliothis virescens
Abstract The metabolic enzymes of a multiresistant (i.e., carbamate, organophosphate, pyrethroid) population of tobacco budworm, Heliothis virescens (F.), were compared with those of a susceptibleExpand
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