Opportunities to Optimize Tacrolimus Therapy in Solid Organ Transplantation: Report of the European Consensus Conference
- P. Wallemacq, V. Armstrong, M. Mourad
- MedicineTherapeutic Drug Monitoring
- 1 April 2009
The importance of obtaining multicenter prospective trials to assess the efficacy of alternative strategies to TAC trough concentrations is emphasized, and single time points, limited sampling strategies, and area under concentration-time curve have all been considered to determine the most appropriate sampling procedure that correlates with efficacy.
The pharmacokinetic-pharmacodynamic relationship for total and free mycophenolic Acid in pediatric renal transplant recipients: a report of the german study group on mycophenolate mofetil therapy.
- L. Weber, M. Shipkova, B. Tönshoff
- MedicineJournal of the American Society of Nephrology
- 1 March 2002
Investigation of the pharmacokinetic (PK)/pharmacodynamic relationship of total and free MPA and PK values for the assessment of an individual's MPA PK parameters indicates that therapeutic drug monitoring of MPA has the potential for optimization of MMF efficacy in this patient population by steering patients away from the low values of M PA PK variables that are associated with an increased rejection risk.
Pharmacokinetics of mycophenolic acid (MPA) and determinants of MPA free fraction in pediatric and adult renal transplant recipients. German Study group on Mycophenolate Mofetil Therapy in Pediatric…
- L. Weber, M. Shipkova, B. Tönshoff
- MedicineJournal of the American Society of Nephrology
- 1 August 1998
Comparing the pharmacokinetics of MPA and its major metabolite MPA glucuronide in pediatric renal transplant recipients receiving 600 mg MMF/m2 body surface area twice a day to those of adults on the currently recommended oral dose of 1 g of MMF once a day is compared.
Identification of glucoside and carboxyl‐linked glucuronide conjugates of mycophenolic acid in plasma of transplant recipients treated with mycophenolate mofetil
- M. Shipkova, V. Armstrong, M. Oellerich
- Biology, ChemistryBritish Journal of Pharmacology
- 1 March 1999
Results suggest that M‐1 is the 7‐OH glucose conjugate of MPA; M‐2 is the acyl glucuronide conjugates of M PA; and M‐3 is derived from the hepatic CYP450 system.
Comparing Mycophenolate Mofetil Regimens for de Novo Renal Transplant Recipients: The Fixed-Dose Concentration-Controlled Trial
- T. van Gelder, H. Silva, R. Mamelok
- MedicineTransplantation
- 27 October 2008
The applied protocol of MMF dose adjustments based on target MPA exposure was not successful, partly because physicians seemed reluctant to implement substantial dose changes.
Digital droplet PCR for rapid quantification of donor DNA in the circulation of transplant recipients as a potential universal biomarker of graft injury.
- J. Beck, Sarah Bierau, E. Schütz
- Medicine, BiologyClinical Chemistry
- 1 December 2013
A novel, cost-effective, rapid technique was developed to quantify GcfDNA in transplant recipients and embodies a promising, potentially universal biomarker for early detection of rejection, which could enable more effective therapeutic interventions.
Therapeutic Drug Monitoring of Mycophenolate Mofetil in Transplantation
- T. van Gelder, Y. Meur, R. Mamelok
- MedicineTherapeutic Drug Monitoring
- 1 April 2006
A roundtable meeting to discuss the use of therapeutic drug monitoring (TDM) to guide immunosuppression with mycophenolate mofetil was held in New York in December 2004, and it was agreed that TDM might help optimize outcomes, especially in patients at higher risk of rejection.
Contribution of CYP3A5 to the in vitro hepatic clearance of tacrolimus.
- L. Kamdem, F. Streit, L. Wojnowski
- Medicine, BiologyClinical Chemistry
- 1 August 2005
CYP3A5 affects metabolism of tacrolimus, thus explaining the association between CYP3A 5 genotype and tacro Limus dosage and the importance of CYP2A5 status for tacroLimus clearance is also dependent on the concomitant CYP4 activity.
Determination of the acyl glucuronide metabolite of mycophenolic acid in human plasma by HPLC and Emit.
- M. Shipkova, E. Schütz, V. Armstrong, P. Niedmann, M. Oellerich, E. Wieland
- Chemistry, MedicineClinical Chemistry
- 1 March 2000
The HPLC and Emit methods for AcMPAG described here may allow investigation of its relevance for the immunosuppression and side effects associated with mycophenolate mofetil therapy as well as investigate its pharmacologic and toxicologic relevance in vivo.
Glucuronide and glucoside conjugation of mycophenolic acid by human liver, kidney and intestinal microsomes
- M. Shipkova, C. Strassburg, E. Wieland
- BiologyBritish Journal of Pharmacology
- 1 March 2001
Investigations of the formation of these metabolites by human liver, kidney, and intestinal microsomes, as well as by recombinant UDP‐glucuronosyltransferases show extrahepatic tissues particularly the kidney may play a significant role in the overall biotransformation of MPA in man.
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