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Thalidomide

Known as: N-Phthalyl-glutaminsaeure-imid, 2,6-Dioxo-3-phthalimidopiperidine, (+-)-Thalidomide 
A synthetic derivative of glutamic acid (alpha-phthalimido-glutarimide) with teratogenic, immunomodulatory, anti-inflammatory and anti-angiogenic… Expand
National Institutes of Health

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Review
2019
Review
2019
Chemotherapy-induced peripheral neuropathy (CIPN) is one of the most frequent side effects caused by antineoplastic agents, with… Expand
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Review
2017
Review
2017
This paper reviews the development of new high-temperature polymeric materials applicable to plastic substrates in image display… Expand
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Highly Cited
2010
Highly Cited
2010
Thalidomide Teratogenicity Target In the late 1950s and early 1960s, thalidomide was prescribed to pregnant women as a cure for… Expand
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Review
2008
Review
2008
The incidence of venous thromboembolism (VTE) is more than 1‰ annually in the general population and increases further in cancer… Expand
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Highly Cited
2000
Highly Cited
2000
Although thalidomide (Thal) was initially used to treat multiple myeloma (MM) because of its known antiangiogenic effects, the… Expand
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Highly Cited
1999
Highly Cited
1999
BACKGROUND Patients with myeloma who relapse after high-dose chemotherapy have few therapeutic options. Since increased bone… Expand
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Highly Cited
1994
Highly Cited
1994
Thalidomide is a potent teratogen causing dysmelia (stunted limb growth) in humans. We have demonstrated that orally administered… Expand
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Highly Cited
1993
Highly Cited
1993
We have examined the mechanism of thalidomide inhibition of lipopolysaccharide (LPS)-induced tumor necrosis factor alpha (TNF… Expand
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Highly Cited
1991
Highly Cited
1991
Thalidomide selectively inhibits the production of human monocyte tumor necrosis factor alpha (TNF-alpha) when these cells are… Expand
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Highly Cited
1961
Highly Cited
1961
Sir,—Congenital abnormalities are present in approximately 1.5% of babies. In recent months I have observed that the incidence of… Expand
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