Thalidomide

Known as: N-Phthalyl-glutaminsaeure-imid, 2,6-Dioxo-3-phthalimidopiperidine, (+-)-Thalidomide 
A synthetic derivative of glutamic acid (alpha-phthalimido-glutarimide) with teratogenic, immunomodulatory, anti-inflammatory and anti-angiogenic… (More)
National Institutes of Health

Papers overview

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Highly Cited
2010
Highly Cited
2010
Half a century ago, thalidomide was widely prescribed to pregnant women as a sedative but was found to be teratogenic, causing… (More)
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Highly Cited
2006
Highly Cited
2006
PURPOSE To determine if thalidomide plus dexamethasone yields superior response rates compared with dexamethasone alone as… (More)
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Highly Cited
2006
Highly Cited
2006
Newer chemotherapeutic protocols as well as high-dose chemotherapy have increased the response rate in myeloma. However, these… (More)
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Highly Cited
2001
Highly Cited
2001
The antiangiogenic activity of thalidomide (Thal), coupled with an increase in bone marrow angiogenesis in multiple myeloma (MM… (More)
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Highly Cited
2000
Highly Cited
2000
Although thalidomide (Thal) was initially used to treat multiple myeloma (MM) because of its known antiangiogenic effects, the… (More)
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Highly Cited
1999
Highly Cited
1999
BACKGROUND Patients with myeloma who relapse after high-dose chemotherapy have few therapeutic options. Since increased bone… (More)
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Highly Cited
1994
Highly Cited
1994
Thalidomide is a potent teratogen causing dysmelia (stunted limb growth) in humans. We have demonstrated that orally administered… (More)
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Highly Cited
1993
Highly Cited
1993
We have examined the mechanism of thalidomide inhibition of lipopolysaccharide (LPS)-induced tumor necrosis factor alpha (TNF… (More)
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Highly Cited
1991
Highly Cited
1991
Thalidomide selectively inhibits the production of human monocyte tumor necrosis factor alpha (TNF-alpha) when these cells are… (More)
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Highly Cited
1961
Highly Cited
1961
determined for each state in the nation. For the first time in many areas, hospital licensure laws were created and implemented… (More)
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