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Thalidomide

Known as: N-Phthalyl-glutaminsaeure-imid, 2,6-Dioxo-3-phthalimidopiperidine, (+-)-Thalidomide 
A synthetic derivative of glutamic acid (alpha-phthalimido-glutarimide) with teratogenic, immunomodulatory, anti-inflammatory and anti-angiogenic… 
National Institutes of Health

Related topics

Related topics

42 relations

Narrower (18)

3-aminophthalimidoglutarimide5'-hydroxythalidomideConterganDistaval

Broader (5)

AminesAnalgesicsLeprostatic AgentsPiperidones
Angiogenesis InhibitionAphthous StomatitisEndothelial CellsErythema Multiforme

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2008
Highly Cited
2008
Perylene bisimide dimers as fluorescent "glue" for DNA and for base-mismatch detection.
Perylene-3,4:9,10-tetracarboxylic acid bisimide (“PB”) and its derivatives are applied as fluorescent dyes in organic materials… 
Highly Cited
2003
Highly Cited
2003
Immunomodulatory analogs of thalidomide inhibit growth of Hs Sultan cells and angiogenesis in vivo
We have previously shown that thalidomide and its potent immunomodulatory derivatives (IMiDs) inhibit the in vitro growth of… 
Review
2003
Review
2003
Treatment of plasma cell dyscrasias with thalidomide and its derivatives.
PURPOSE In 1999, investigators reported promising results of a phase II study of thalidomide in patients with resistant multiple… 
Review
2000
Review
2000
'Accidental' anti-angiogenic drugs. anti-oncogene directed signal transduction inhibitors and conventional chemotherapeutic agents as examples.
Highly Cited
1997
Highly Cited
1997
T-cell antigen receptor transmembrane peptides modulate T-cell function and T cell-mediated disease
This study describes a novel method of inhibiting T-cell function by the use of peptides rationally designed from the T-cell… 
Highly Cited
1973
Highly Cited
1973
Birth defects and oral contraceptives.
Highly Cited
1973
Highly Cited
1973
Affinity chromatography of nicotinamide-adenine dinucleotide-linked dehydrogenases on immobilized derivatives of the dinucleotide.
1. Three established methods for immobilization of ligands through primary amino groups promoted little or no attachment of NAD… 
Highly Cited
1972
Highly Cited
1972
General ligands in affinity chromatography. Cofactor-substrate elution of enzymes bound to the immobilized nucleotides adenosine 5'-monophosphate and nicotinamide-adenine dinucleotide.
1. Two different gels have been prepared suitable for the separation of a number of enzymes, in particular NAD(+)-dependent… 
Highly Cited
1971
Highly Cited
1971
The identification of the site of action of dicyclohexylcarbodi-imide as a proteolipid in mitochondrialmembranes.
Mitochondrial membranes were incubated with NN′-dicyclohexyl[14C]carbodi-imide, which irreversibly inhibited the partial… 
Highly Cited
1947
Highly Cited
1947
DISEASE
Background: Little is known about patients who frequently visit the emergency department (ED) for acute exacerbation of chronic… 
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