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Thalidomide
Known as:
N-Phthalyl-glutaminsaeure-imid
, 2,6-Dioxo-3-phthalimidopiperidine
, (+-)-Thalidomide
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A synthetic derivative of glutamic acid (alpha-phthalimido-glutarimide) with teratogenic, immunomodulatory, anti-inflammatory and anti-angiogenic…
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National Institutes of Health
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Related topics
Related topics
42 relations
Narrower (18)
3-aminophthalimidoglutarimide
5'-hydroxythalidomide
Contergan
Distaval
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Broader (5)
Amines
Analgesics
Leprostatic Agents
Piperidones
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Angiogenesis Inhibition
Aphthous Stomatitis
Endothelial Cells
Erythema Multiforme
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Papers overview
Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2010
Highly Cited
2010
Identification of a Primary Target of Thalidomide Teratogenicity
Takumi Ito
,
H. Ando
,
+5 authors
H. Handa
Science
2010
Corpus ID: 17575104
Thalidomide Teratogenicity Target In the late 1950s and early 1960s, thalidomide was prescribed to pregnant women as a cure for…
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Review
2008
Review
2008
Prevention of thalidomide- and lenalidomide-associated thrombosis in myeloma
A. Palumbo
,
S. Rajkumar
,
+31 authors
M. Hussein
Leukemia
2008
Corpus ID: 6140120
The incidence of venous thromboembolism (VTE) is more than 1‰ annually in the general population and increases further in cancer…
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Highly Cited
2006
Highly Cited
2006
Thalidomide and hematopoietic-cell transplantation for multiple myeloma.
B. Barlogie
,
G. Tricot
,
+14 authors
J. Crowley
New England Journal of Medicine
2006
Corpus ID: 30742963
BACKGROUND High-dose therapy with melphalan can prolong survival among patients with multiple myeloma. We assessed whether the…
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Highly Cited
2003
Highly Cited
2003
Thalidomide alone or with dexamethasone for previously untreated multiple myeloma.
D. Weber
,
K. Rankin
,
M. Gavino
,
K. Delasalle
,
R. Alexanian
Journal of Clinical Oncology
2003
Corpus ID: 2070196
PURPOSE To evaluate the activity of thalidomide in patients with asymptomatic multiple myeloma and of thalidomide-dexamethasone…
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Highly Cited
2003
Highly Cited
2003
Asymmetric transition-metal-catalyzed allylic alkylations: applications in total synthesis.
B. Trost
,
M. L. Crawley
Chemical Reviews
2003
Corpus ID: 32189701
A. Primary Alcohols as Nucleophiles 2931 B. Carboxylates as Nucleophiles 2931 C. Alkylations with Phenols 2932 IV. Nitrogen…
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Highly Cited
1999
Highly Cited
1999
Antitumor activity of thalidomide in refractory multiple myeloma.
S. Singhal
,
J. Mehta
,
+9 authors
B. Barlogie
New England Journal of Medicine
1999
Corpus ID: 45150547
BACKGROUND Patients with myeloma who relapse after high-dose chemotherapy have few therapeutic options. Since increased bone…
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Highly Cited
1994
Highly Cited
1994
Thalidomide is an inhibitor of angiogenesis.
R. D'Amato
,
M. Loughnan
,
E. Flynn
,
J. Folkman
Proceedings of the National Academy of Sciences…
1994
Corpus ID: 23760591
Thalidomide is a potent teratogen causing dysmelia (stunted limb growth) in humans. We have demonstrated that orally administered…
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Highly Cited
1993
Highly Cited
1993
Thalidomide exerts its inhibitory action on tumor necrosis factor alpha by enhancing mRNA degradation
A. Moreira
,
E. Sampaio
,
A. Zmuidzinas
,
P. Frindt
,
K. Smith
,
G. Kaplan
Journal of Experimental Medicine
1993
Corpus ID: 1777308
We have examined the mechanism of thalidomide inhibition of lipopolysaccharide (LPS)-induced tumor necrosis factor alpha (TNF…
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Highly Cited
1991
Highly Cited
1991
Thalidomide selectively inhibits tumor necrosis factor alpha production by stimulated human monocytes
E. Sampaio
,
E. Sarno
,
R. Galilly
,
Z. Cohn
,
G. Kaplan
Journal of Experimental Medicine
1991
Corpus ID: 2255027
Thalidomide selectively inhibits the production of human monocyte tumor necrosis factor alpha (TNF-alpha) when these cells are…
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Highly Cited
1947
Highly Cited
1947
DISEASE
R. Baggott
Social Policy & Administration
1947
Corpus ID: 222064452
Background: Little is known about patients who frequently visit the emergency department (ED) for acute exacerbation of chronic…
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