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Thalidomide

Known as: N-Phthalyl-glutaminsaeure-imid, 2,6-Dioxo-3-phthalimidopiperidine, (+-)-Thalidomide 
A synthetic derivative of glutamic acid (alpha-phthalimido-glutarimide) with teratogenic, immunomodulatory, anti-inflammatory and anti-angiogenic… 
National Institutes of Health

Related topics

Related topics

42 relations

Narrower (18)

3-aminophthalimidoglutarimide5'-hydroxythalidomideConterganDistaval

Broader (5)

AminesAnalgesicsLeprostatic AgentsPiperidones
Angiogenesis InhibitionAphthous StomatitisEndothelial CellsErythema Multiforme

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2010
Highly Cited
2010
Identification of a Primary Target of Thalidomide Teratogenicity
Thalidomide Teratogenicity Target In the late 1950s and early 1960s, thalidomide was prescribed to pregnant women as a cure for… 
Review
2008
Review
2008
Prevention of thalidomide- and lenalidomide-associated thrombosis in myeloma
The incidence of venous thromboembolism (VTE) is more than 1‰ annually in the general population and increases further in cancer… 
Highly Cited
2006
Highly Cited
2006
Thalidomide and hematopoietic-cell transplantation for multiple myeloma.
BACKGROUND High-dose therapy with melphalan can prolong survival among patients with multiple myeloma. We assessed whether the… 
Highly Cited
2003
Highly Cited
2003
Thalidomide alone or with dexamethasone for previously untreated multiple myeloma.
PURPOSE To evaluate the activity of thalidomide in patients with asymptomatic multiple myeloma and of thalidomide-dexamethasone… 
Highly Cited
2003
Highly Cited
2003
Asymmetric transition-metal-catalyzed allylic alkylations: applications in total synthesis.
A. Primary Alcohols as Nucleophiles 2931 B. Carboxylates as Nucleophiles 2931 C. Alkylations with Phenols 2932 IV. Nitrogen… 
Highly Cited
1999
Highly Cited
1999
Antitumor activity of thalidomide in refractory multiple myeloma.
BACKGROUND Patients with myeloma who relapse after high-dose chemotherapy have few therapeutic options. Since increased bone… 
Highly Cited
1994
Highly Cited
1994
Thalidomide is an inhibitor of angiogenesis.
Thalidomide is a potent teratogen causing dysmelia (stunted limb growth) in humans. We have demonstrated that orally administered… 
Highly Cited
1993
Highly Cited
1993
Thalidomide exerts its inhibitory action on tumor necrosis factor alpha by enhancing mRNA degradation
We have examined the mechanism of thalidomide inhibition of lipopolysaccharide (LPS)-induced tumor necrosis factor alpha (TNF… 
Highly Cited
1991
Highly Cited
1991
Thalidomide selectively inhibits tumor necrosis factor alpha production by stimulated human monocytes
Thalidomide selectively inhibits the production of human monocyte tumor necrosis factor alpha (TNF-alpha) when these cells are… 
Highly Cited
1947
Highly Cited
1947
DISEASE
  • R. Baggott
  • Social Policy & Administration
  • 1947
  • Corpus ID: 222064452
Background: Little is known about patients who frequently visit the emergency department (ED) for acute exacerbation of chronic… 
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