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Identification and characterization of polymorphisms in the promoter region of the human Apo-1/Fas (CD95) gene.
Pairwise, cooperative and inhibitory interactions describe the assembly and probable structure of the T‐cell antigen receptor.
The molecular basis of subunit interactions and the component requirements leading to the formation of a complete TCR were examined and analysis of transient cotransfections in monkey kidney fibroblasts showed assembly between selective chain pairs.
Depression and anxiety in patients with rheumatoid arthritis: prevalence rates based on a comparison of the Depression, Anxiety and Stress Scale (DASS) and the hospital, Anxiety and Depression Scale…
Cut points for depression were comparable across the two scales while a lower cut point for anxiety in the DASS was required to equate prevalence, showing that while these two scales provide a good indication of possible depression and anxiety, the estimates of prevalence so derived could vary, particularly for anxiety.
Evaluation of a new Apo-1/Fas promoter polymorphism in rheumatoid arthritis and systemic lupus erythematosus patients.
The role of the Apo-1/Fas gene promoter MvaI polymorphism in RA and SLE is unclear and further substantiation in larger patient samples is needed.
T-cell antigen receptor transmembrane peptides modulate T-cell function and T cell-mediated disease
- N. Manolios, S. Collier, J. Taylor, J. Pollard, L. Harrison, V. Bender
- Biology, MedicineNature Medicine
CP reduced clinical signs of inflammation in three T cell-mediated disease models including adjuvant-induced arthritis, experimental allergic neuritis, and cyclophosphamide-induced diabetes in NOD/Lt(F) mice and has potential as a therapeutic agent in human inflammatory and autoimmune disorders.
New onset sarcoid‐like granulomatosis developing during anti‐TNF therapy: an under‐recognised complication
Development of sarcoidosis‐like granulomatosis in patients treated with TNF‐α antagonists is a phenomenon previously under‐recognised, suggesting a ‘class effect’ rather than being drug specific.
Transmembrane helical interactions and the assembly of the T cell receptor complex.
Studies of the subunit interactions of the multicomponent T cell antigen receptor (TCR) revealed that specific pairs of chains have the ability to assemble after transfection into fibroblasts, suggesting that well-defined helical interactions in the membrane can explain the assembly of some multichain membrane complexes.
Transmembrane helical interactions: zeta chain dimerization and functional association with the T cell antigen receptor.
- T. Rutledge, P. Cosson, N. Manolios, J. Bonifacino, R. Klausner
- Biology, ChemistryThe EMBO journal
- 1 September 1992
expression of zeta mutants in zeta‐deficient T cells revealed that the zeta transmembrane domain is also responsible for reconstituting transport of functional TCR complexes to the cell surface and differentiated the requirements for disulfide‐linked dimerization per se from assembly of the TCR complex.
INVESTIGATION OF THE -1377 POLYMORPHISM ON THE APO-1/FAS PROMOTER IN SYSTEMIC LUPUS ERYTHEMATOSUS PATIENTS USING ALLELE-SPECIFIC AMPLIFICATION
The results showed that both genotype distribution and allele frequencies in SLE patients were similar to that in controls, suggesting that the -1377 promoter polymorphism is unlikely to be associated with SLE susceptibility.
Familial risk estimation in systemic sclerosis.
- H. Englert, J. Small-McMahon, P. Brooks
- Medicine, PsychologyAustralian and New Zealand journal of medicine
- 1 February 1999
This study substantially increases the otherwise small list of documented instances of familial systemic sclerosis and quantifies the risk for the first time, ranking it as the disease's most powerful determinant identified to date.