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Pro-Inflammatory CD11c+CD206+ Adipose Tissue Macrophages Are Associated With Insulin Resistance in Human Obesity
OBJECTIVE Insulin resistance and other features of the metabolic syndrome have been causally linked to adipose tissue macrophages (ATMs) in mice with diet-induced obesity. We aimed to characterizeExpand
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Prediction of MHC class II-binding peptides using an evolutionary algorithm and artificial neural network
MOTIVATION Prediction methods for identifying binding peptides could minimize the number of peptides required to be synthesized, and thereby facilitate the identification of potential T-cell epitopes. Expand
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Gut microbial metabolites limit the frequency of autoimmune T cells and protect against type 1 diabetes
Gut dysbiosis might underlie the pathogenesis of type 1 diabetes. In mice of the non-obese diabetic (NOD) strain, we found that key features of disease correlated inversely with blood and fecalExpand
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Human Dendritic Cell Subsets from Spleen and Blood Are Similar in Phenotype and Function but Modified by Donor Health Status
Mouse dendritic cells (DC) have been extensively studied in various tissues, especially spleen, and they comprise subsets with distinct developmental origins, surface phenotypes, and functions.Expand
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Diurnal rhythms of pro-inflammatory cytokines: regulation by plasma cortisol and therapeutic implications.
Clinical features of certain immuno-inflammatory disorders such as rheumatoid arthritis and asthma exhibit diurnal fluctuation, which could be related to diurnal rhythmicity of pro-inflammatoryExpand
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Responses against islet antigens in NOD mice are prevented by tolerance to proinsulin but not IGRP.
Type 1 diabetes (T1D) is characterized by immune responses against several autoantigens expressed in pancreatic beta cells. T cells specific for proinsulin and islet-specific glucose-6-phosphataseExpand
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Insulin resistance is a risk factor for progression to Type 1 diabetes
AIMS/HYPOTHESIS Glucose homeostasis is determined by an interplay between insulin secretion and insulin action. In type 1 diabetes, autoimmune destruction of pancreatic beta cells leads to impairedExpand
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T-Cell Epitopes in Type 1 Diabetes Autoantigen Tyrosine Phosphatase IA-2: Potential for Mimicry with Rotavirus and Other Environmental Agents
The tyrosine phosphatase IA-2 is a molecular target of pancreatic islet autoimmunity in type 1 diabetes. T-cell epitope peptides in autoantigens have potential diagnostic and therapeuticExpand
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MHCPEP, a database of MHC-binding peptides: update 1997
MHCPEP (http://wehih.edu.au/mhcpep/) is a curated database comprising over 13 000 peptide sequences known to bind MHC molecules. Expand
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T cell regulation mediated by interaction of soluble CD52 with the inhibitory receptor Siglec-10
Functionally diverse T cell populations interact to maintain homeostasis of the immune system. We found that human and mouse antigen-activated T cells with high expression of the lymphocyte surfaceExpand
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