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- Publications
- Influence
Pro-Inflammatory CD11c+CD206+ Adipose Tissue Macrophages Are Associated With Insulin Resistance in Human Obesity
- J. Wentworth, G. Naselli, +6 authors L. Harrison
- Biology, Medicine
- Diabetes
- 31 March 2010
OBJECTIVE Insulin resistance and other features of the metabolic syndrome have been causally linked to adipose tissue macrophages (ATMs) in mice with diet-induced obesity. We aimed to characterize… Expand
Prediction of MHC class II-binding peptides using an evolutionary algorithm and artificial neural network
- V. Brusic, G. Rudy, G. Honeyman, J. Hammer, L. Harrison
- Biology, Computer Science
- Bioinform.
- 1998
TLDR
Gut microbial metabolites limit the frequency of autoimmune T cells and protect against type 1 diabetes
- E. Mariño, J. L. Richards, +21 authors C. Mackay
- Biology, Medicine
- Nature Immunology
- 1 May 2017
Gut dysbiosis might underlie the pathogenesis of type 1 diabetes. In mice of the non-obese diabetic (NOD) strain, we found that key features of disease correlated inversely with blood and fecal… Expand
Human Dendritic Cell Subsets from Spleen and Blood Are Similar in Phenotype and Function but Modified by Donor Health Status
- D. Mittag, Anna I. Proietto, +5 authors L. Harrison
- Biology, Medicine
- The Journal of Immunology
- 1 June 2011
Mouse dendritic cells (DC) have been extensively studied in various tissues, especially spleen, and they comprise subsets with distinct developmental origins, surface phenotypes, and functions.… Expand
Diurnal rhythms of pro-inflammatory cytokines: regulation by plasma cortisol and therapeutic implications.
- N. Petrovsky, P. McNair, L. Harrison
- Medicine
- Cytokine
- 1 April 1998
Clinical features of certain immuno-inflammatory disorders such as rheumatoid arthritis and asthma exhibit diurnal fluctuation, which could be related to diurnal rhythmicity of pro-inflammatory… Expand
Responses against islet antigens in NOD mice are prevented by tolerance to proinsulin but not IGRP.
- B. Krishnamurthy, N. Dudek, +8 authors T. Kay
- Biology, Medicine
- The Journal of clinical investigation
- 1 December 2006
Type 1 diabetes (T1D) is characterized by immune responses against several autoantigens expressed in pancreatic beta cells. T cells specific for proinsulin and islet-specific glucose-6-phosphatase… Expand
Insulin resistance is a risk factor for progression to Type 1 diabetes
- S. Fourlanos, P. Narendran, G. Byrnes, P. Colman, L. Harrison
- Biology, Medicine
- Diabetologia
- 2004
AIMS/HYPOTHESIS
Glucose homeostasis is determined by an interplay between insulin secretion and insulin action. In type 1 diabetes, autoimmune destruction of pancreatic beta cells leads to impaired… Expand
T-Cell Epitopes in Type 1 Diabetes Autoantigen Tyrosine Phosphatase IA-2: Potential for Mimicry with Rotavirus and Other Environmental Agents
- Margo C Honeyman, N. Stone, L. Harrison
- Biology, Medicine
- Molecular medicine
- 1 April 1998
The tyrosine phosphatase IA-2 is a molecular target of pancreatic islet autoimmunity in type 1 diabetes. T-cell epitope peptides in autoantigens have potential diagnostic and therapeutic… Expand
MHCPEP, a database of MHC-binding peptides: update 1997
- V. Brusic, G. Rudy, L. Harrison
- Biology, Computer Science
- Nucleic Acids Res.
- 1998
TLDR
T cell regulation mediated by interaction of soluble CD52 with the inhibitory receptor Siglec-10
- E. Bandala-Sánchez, Yu-xia Zhang, +5 authors L. Harrison
- Chemistry, Medicine
- Nature Immunology
- 1 July 2013
Functionally diverse T cell populations interact to maintain homeostasis of the immune system. We found that human and mouse antigen-activated T cells with high expression of the lymphocyte surface… Expand