T-cell antigen receptor transmembrane peptides modulate T-cell function and T cell-mediated disease

@article{Manolios1997TcellAR,
  title={T-cell antigen receptor transmembrane peptides modulate T-cell function and T cell-mediated disease},
  author={Nicholas Manolios and Simon Collier and Jude Matthew Taylor and John David Pollard and Leonard C. Harrison and Veronica Bender},
  journal={Nature Medicine},
  year={1997},
  volume={3},
  pages={84-88}
}
This study describes a novel method of inhibiting T-cell function by the use of peptides rationally designed from the T-cell antigen receptor (TCR) alpha-chain transmembrane sequence involved with TCR receptor assembly. The most effective peptide (core peptide, CP) modulating in vitro and in vivo T-cell function contained nine amino acids two of which, lysine and arginine, were hydrophilic and separated by four hydrophobic amino acids. CP without chemical modification or conjugation was able to… CONTINUE READING
18 Citations
0 References
Similar Papers

Citations

Publications citing this paper.
Showing 1-10 of 18 extracted citations

Similar Papers

Loading similar papers…