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Piperidones

Known as: Piperidones [Chemical/Ingredient], piperidone 
 
National Institutes of Health

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1,3-dimethyl-2-piperidinone1,5-dimethyl-2-piperidinone1-benzyl-4-piperidone1-methyl-3-carbomethoxy-piperidone-4
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In Bloodagonistsantagonists & inhibitorsaspects of radiation effects
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Papers overview

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2014
2014
HO-3867, a safe STAT3 inhibitor, is selectively cytotoxic to ovarian cancer.
STAT3 is well corroborated preclinically as a cancer therapeutic target, but tractable translational strategies for its blockade… Expand
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Highly Cited
2013
Highly Cited
2013
A bis-benzylidine piperidone targeting proteasome ubiquitin receptor RPN13/ADRM1 as a therapy for cancer.
The bis-benzylidine piperidone RA190 covalently binds to cysteine 88 of ubiquitin receptor RPN13 in the 19S regulatory particle… Expand
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Highly Cited
2013
Highly Cited
2013
Synthesis and discovery of novel piperidone-grafted mono- and bis-spirooxindole-hexahydropyrrolizines as potent cholinesterase inhibitors.
Three-component reaction of a series of 1-acryloyl-3,5-bisbenzylidenepiperidin-4-ones with isatin and L-proline in 1:1:1 and 1:2… Expand
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2013
2013
Asymmetric conjugate addition of malonate esters to α,β-unsaturated N-sulfonyl imines: an expeditious route to chiral δ-aminoesters and piperidones.
The asymmetric conjugate addition of malonate esters to α,β-unsaturated N-sulfonyl imines is catalyzed by PyBOX/La(OTf)3… Expand
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2013
2013
An expedient, ionic liquid mediated multi-component synthesis of novel piperidone grafted cholinesterase enzymes inhibitors and their molecular modeling study.
Series of hitherto unreported piperidone grafted pyridopyrimidines synthesized through ionic liquid mediated multi-component… Expand
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Highly Cited
2011
Highly Cited
2011
Synthesis of N-substituted 3,5-bis(arylidene)-4-piperidones with high antitumor and antioxidant activity.
A series of 3,5-bis(arylidene)-4-piperidone (DAP) compounds are considered as synthetic analogues of curcumin for anticancer… Expand
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2010
2010
Safe and targeted anticancer efficacy of a novel class of antioxidant-conjugated difluorodiarylidenyl piperidones: differential cytotoxicity in healthy and cancer cells.
The development of smart anticancer drugs that can selectively kill cancer cells while sparing the surrounding healthy tissues… Expand
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Highly Cited
2010
Highly Cited
2010
Anticancer Efficacy of a Difluorodiarylidenyl Piperidone (HO-3867) in Human Ovarian Cancer Cells and Tumor Xenografts
The purpose of this study was to evaluate the anticancer potency and mechanism of a novel difluorodiarylidenyl piperidone (H-4073… Expand
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Highly Cited
2006
Highly Cited
2006
Identification of peptide metabolites of Microcystis (Cyanobacteria) that inhibit trypsin-like activity in planktonic herbivorous Daphnia (Cladocera).
Cyanobacteria are recognized as producers of a broad variety of bioactive metabolites. Among these, the peptides synthesized by… Expand
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Highly Cited
1975
Highly Cited
1975
Induction of erythroid differentiation in murine virus infected eythroleukemia cells by highly polar compounds.
Murine-virus-infected erythroleukemia cells cultured in a medium with dimethylsulfoxide or N,N-dimethylformamide are induced to… Expand
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