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TYROBP gene

Known as: TYRO protein tyrosine kinase binding protein, KARAP, TYROBP 
This gene plays a role in signal transduction for a variety of cellular processes.
National Institutes of Health

Related topics

Related topics

5 relations
Ligand BindingSignal TransductionTYRO Protein Tyrosine Kinase Binding ProteinTYROBP wt Allele

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2014
Highly Cited
2014
TGF-β–inducible microRNA-183 silences tumor-associated natural killer cells
Significance Natural killer (NK) cells are potent tumor-cell killers, but exposure to transforming growth factor beta-1 (TGF… 
Highly Cited
2013
Highly Cited
2013
The interaction between Siglec-15 and tumor-associated sialyl-Tn antigen enhances TGF-β secretion from monocytes/macrophages through the DAP12-Syk pathway.
We previously demonstrated that Siglec-15, a member of the Siglec family of glycan-recognition proteins, is expressed on a subset… 
Review
2009
Review
2009
Molecular mediators of macrophage fusion.
Highly Cited
2005
Highly Cited
2005
Enhanced Toll-like receptor responses in the absence of signaling adaptor DAP12
DAP12 is a signaling adaptor containing an immunoreceptor tyrosine-based activation motif (ITAM) that pairs with receptors on… 
Highly Cited
2004
Highly Cited
2004
Impaired Synaptic Function in the Microglial KARAP/DAP12-Deficient Mouse
Several proteins are expressed in both immune and nervous systems. However, their putative nonimmune functions in the brain… 
Highly Cited
2003
Highly Cited
2003
Characterization of the CD200 Receptor Family in Mice and Humans and Their Interactions with CD200 1
CD200 (OX2) is a broadly distributed cell surface glycoprotein that interacts with a structurally related receptor (CD200R… 
Highly Cited
2003
Highly Cited
2003
Selective Activation of the c-Jun NH2-terminal Protein Kinase Signaling Pathway by Stimulatory KIR in the Absence of KARAP/DAP12 in CD4+ T Cells
Activation of CD4+ T cells is governed by interplay between stimulatory and inhibitory receptors; predominance of stimulatory… 
Highly Cited
2002
Highly Cited
2002
TREM-1, MDL-1, and DAP12 expression is associated with a mature stage of myeloid development.
Highly Cited
2000
Highly Cited
2000
DAP12-deficient mice fail to develop autoimmunity due to impaired antigen priming.
Highly Cited
2000
Highly Cited
2000
Combined natural killer cell and dendritic cell functional deficiency in KARAP/DAP12 loss-of-function mutant mice.
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