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TOP3A gene

Known as: zinc finger, GRF-type containing 7, TOP3A, topoisomerase (DNA) III alpha 
This gene plays a role in the regulation of DNA topology and recombination in somatic cells.
National Institutes of Health

Related topics

Related topics

7 relations
DNA Topology RegulationDNA topoisomerase IIIDNA topoisomerase III alphaRecombination, Genetic

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TOP3A wt Allele

Papers overview

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2020
2020
Mining topoisomerase isoforms in gastric cancer.
2013
2013
Resolution by Unassisted Top3 Points to Template Switch Recombination Intermediates during DNA Replication*
Background: The Sgs1/Top3/Rmi1 (STR) complex resolves DNA linkages formed during replication of methyl methanesulfonate (MMS… 
2012
2012
TOP3A, a new partner gene fused to MLL in an adult patient with de novo acute myeloid leukaemia
Chromosomal rearrangements involving the MLL gene at chromosome band 11q23 are recurrent events in acute leukaemia. Recently… 
2009
2009
WRN helicase defective in the premature aging disorder Werner syndrome genetically interacts with topoisomerase 3 and restores the top3 slow growth phenotype of sgs1 top3
Werner syndrome (WS) is a premature aging disorder characterized by genomic instability. The WRN gene defective in WS encodes a… 
2006
2006
Top3 processes recombination intermediates and modulates checkpoint activity after DNA damage.
Mutation of TOP3 in Saccharomyces cerevisiae causes poor growth, hyperrecombination, and a failure to fully activate DNA damage… 
2006
2006
Topoisomerase deficiencies subtly enhance global genomic repair of ultraviolet-induced DNA damage in Saccharomyces cerevisiae.
2002
2002
Functional and physical interaction between Sgs1 and Top3 and Sgs1-independent function of Top3 in DNA recombination repair.
A mutant allele of SGS1 of Saccharomyces cerevisiae was identified as a suppressor of the slow-growth phenotype of top3 mutants… 
2002
2002
Coaction of DNA topoisomerase IIIα and a RecQ homologue during the germ‐line mitosis in Caenorhabditis elegans
Background: Among the four RecQ homologues predicted from the Caenorhabditis elegans genomic DNA sequence, T04A11.6 is most… 
1998
1998
Isolation of a cDNA encoding mouse DNA topoisomerase III which is highly expressed at the mRNA level in the testis.
1994
1994
Evidence for a nucleotide-dependent topoisomerase activity from yeast mitochondria
Yeast mitochondria were found to contain a novel topoisomerase-like activity which required nucleoside di- or tri-phosphates as a… 
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