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TOP3A gene
Known as:
zinc finger, GRF-type containing 7
, TOP3A
, topoisomerase (DNA) III alpha
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This gene plays a role in the regulation of DNA topology and recombination in somatic cells.
National Institutes of Health
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Related topics
Related topics
7 relations
DNA Topology Regulation
DNA topoisomerase III
DNA topoisomerase III alpha
Recombination, Genetic
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TOP3A wt Allele
Papers overview
Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2017
Highly Cited
2017
Integrated Molecular Meta-Analysis of 1,000 Pediatric High-Grade and Diffuse Intrinsic Pontine Glioma
A. Mackay
,
A. Burford
,
+60 authors
Chris Jones
Cancer cell
2017
Corpus ID: 4589695
Highly Cited
2015
Highly Cited
2015
Pervasive and essential roles of the Top3-Rmi1 decatenase orchestrate recombination and facilitate chromosome segregation in meiosis.
Shangming Tang
,
Michelle Wu
,
Ruoxi Zhang
,
N. Hunter
Molecular cell
2015
Corpus ID: 206991338
Highly Cited
2006
Highly Cited
2006
Topoisomerase IIIalpha and Bloom's helicase can resolve a mobile double Holliday junction substrate through convergent branch migration.
J. Plank
,
Jianhong Wu
,
T. Hsieh
Proceedings of the National Academy of Sciences…
2006
Corpus ID: 22339577
It has long been suspected that a double Holliday junction (dHJ) could be resolved by a topoisomerase partnered with a helicase…
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Highly Cited
2005
Highly Cited
2005
RMI1/NCE4, a suppressor of genome instability, encodes a member of the RecQ helicase/Topo III complex
Michael Chang
,
M. Bellaoui
,
+7 authors
Grant W. Brown
The EMBO journal
2005
Corpus ID: 10527881
SGS1 encodes a DNA helicase whose homologues in human cells include the BLM, WRN, and RECQ4 genes, mutations in which lead to…
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Highly Cited
2001
Highly Cited
2001
Requirement for three novel protein complexes in the absence of the Sgs1 DNA helicase in Saccharomyces cerevisiae.
J. Mullen
,
V. Kaliraman
,
S. Ibrahim
,
S. Brill
Genetics
2001
Corpus ID: 25025646
The Saccharomyces cerevisiae Sgs1 protein is a member of the RecQ family of DNA helicases and is required for genome stability…
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Highly Cited
2001
Highly Cited
2001
Functional overlap between Sgs1-Top3 and the Mms4-Mus81 endonuclease.
V. Kaliraman
,
J. Mullen
,
W. M. Fricke
,
S. Bastin-Shanower
,
S. Brill
Genes & development
2001
Corpus ID: 24574386
The RecQ DNA helicases, human BLM and yeast Sgs1, form a complex with topoisomerase III (Top3) and are thought to act during DNA…
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Highly Cited
2000
Highly Cited
2000
The Bloom's Syndrome Gene Product Interacts with Topoisomerase III*
Leonard Wu
,
S. Davies
,
+5 authors
I. Hickson
The Journal of Biological Chemistry
2000
Corpus ID: 26410285
Bloom's syndrome is a rare genetic disorder associated with loss of genomic integrity and a large increase in the incidence of…
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Highly Cited
1996
Highly Cited
1996
Human TOP3: a single-copy gene encoding DNA topoisomerase III.
R. Hanai
,
P. Caron
,
J. Wang
Proceedings of the National Academy of Sciences…
1996
Corpus ID: 22975344
A human cDNA encoding a protein homologous to the Escherichia coli DNA topoisomerase I subfamily of enzymes has been identified…
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Highly Cited
1994
Highly Cited
1994
The yeast type I topoisomerase Top3 interacts with Sgs1, a DNA helicase homolog: a potential eukaryotic reverse gyrase.
S. Gangloff
,
J. P. McDonald
,
C. Bendixen
,
L. Arthur
,
R. Rothstein
Molecular and cellular biology
1994
Corpus ID: 25847084
We have previously shown that cells mutant for TOP3, a gene encoding a prokaryotic-like type I topoisomerase in Saccharomyces…
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Highly Cited
1989
Highly Cited
1989
A hyper-recombination mutation in S. cerevisiae identifies a novel eukaryotic topoisomerase
J. Wallis
,
G. Chrebet
,
G. Brodsky
,
M. Rolfe
,
R. Rothstein
Cell
1989
Corpus ID: 25558861
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