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TOP3A gene

Known as: zinc finger, GRF-type containing 7, TOP3A, topoisomerase (DNA) III alpha 
This gene plays a role in the regulation of DNA topology and recombination in somatic cells.
National Institutes of Health

Related topics

Related topics

7 relations
DNA Topology RegulationDNA topoisomerase IIIDNA topoisomerase III alphaRecombination, Genetic
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TOP3A wt Allele

Papers overview

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Highly Cited
2017
Highly Cited
2017
Integrated Molecular Meta-Analysis of 1,000 Pediatric High-Grade and Diffuse Intrinsic Pontine Glioma
Summary We collated data from 157 unpublished cases of pediatric high-grade glioma and diffuse intrinsic pontine glioma and 20… Expand
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Highly Cited
2005
Highly Cited
2005
RMI1/NCE4, a suppressor of genome instability, encodes a member of the RecQ helicase/Topo III complex
SGS1 encodes a DNA helicase whose homologues in human cells include the BLM, WRN, and RECQ4 genes, mutations in which lead to… Expand
Highly Cited
2001
Highly Cited
2001
Requirement for three novel protein complexes in the absence of the Sgs1 DNA helicase in Saccharomyces cerevisiae.
The Saccharomyces cerevisiae Sgs1 protein is a member of the RecQ family of DNA helicases and is required for genome stability… Expand
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Highly Cited
2001
Highly Cited
2001
Functional overlap between Sgs1-Top3 and the Mms4-Mus81 endonuclease.
The RecQ DNA helicases, human BLM and yeast Sgs1, form a complex with topoisomerase III (Top3) and are thought to act during DNA… Expand
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Highly Cited
2000
Highly Cited
2000
The Bloom's Syndrome Gene Product Interacts with Topoisomerase III*
Bloom's syndrome is a rare genetic disorder associated with loss of genomic integrity and a large increase in the incidence of… Expand
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Highly Cited
1999
Highly Cited
1999
The essential role of yeast topoisomerase III in meiosis depends on recombination
Yeast cells mutant for TOP3, the gene encoding the evolutionary conserved type I‐5′ topoisomerase, display a wide range of… Expand
Highly Cited
1999
Highly Cited
1999
Topoisomerase III is essential for accurate nuclear division in Schizosaccharomyces pombe.
Topoisomerases catalyse changes in the topological state of DNA and are required for many aspects of DNA metabolism. While the… Expand
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Highly Cited
1996
Highly Cited
1996
Human TOP3: a single-copy gene encoding DNA topoisomerase III.
A human cDNA encoding a protein homologous to the Escherichia coli DNA topoisomerase I subfamily of enzymes has been identified… Expand
Highly Cited
1994
Highly Cited
1994
The yeast type I topoisomerase Top3 interacts with Sgs1, a DNA helicase homolog: a potential eukaryotic reverse gyrase.
We have previously shown that cells mutant for TOP3, a gene encoding a prokaryotic-like type I topoisomerase in Saccharomyces… Expand
Highly Cited
1989
Highly Cited
1989
A hyper-recombination mutation in S. cerevisiae identifies a novel eukaryotic topoisomerase
A hyper-recombination mutation was isolated that causes an increase in recombination between short repeated delta sequences… Expand
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