Skip to search formSkip to main content
You are currently offline. Some features of the site may not work correctly.

TOP3A gene

Known as: zinc finger, GRF-type containing 7, TOP3A, topoisomerase (DNA) III alpha 
This gene plays a role in the regulation of DNA topology and recombination in somatic cells.
National Institutes of Health

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2017
Highly Cited
2017
Summary We collated data from 157 unpublished cases of pediatric high-grade glioma and diffuse intrinsic pontine glioma and 20… Expand
  • figure 1
  • figure 4
  • figure 5
  • figure 6
  • figure 7
Highly Cited
2005
Highly Cited
2005
SGS1 encodes a DNA helicase whose homologues in human cells include the BLM, WRN, and RECQ4 genes, mutations in which lead to… Expand
Highly Cited
2001
Highly Cited
2001
The Saccharomyces cerevisiae Sgs1 protein is a member of the RecQ family of DNA helicases and is required for genome stability… Expand
  • table 1
  • table 2
  • figure 1
  • figure 2
  • figure 3
Highly Cited
2001
Highly Cited
2001
The RecQ DNA helicases, human BLM and yeast Sgs1, form a complex with topoisomerase III (Top3) and are thought to act during DNA… Expand
  • figure 1
  • figure 2
  • figure 3
  • figure 4
  • figure 5
Highly Cited
2000
Highly Cited
2000
Bloom's syndrome is a rare genetic disorder associated with loss of genomic integrity and a large increase in the incidence of… Expand
  • figure 1
  • figure 3
  • figure 2
  • figure 4
  • figure 5
Highly Cited
1999
Highly Cited
1999
Yeast cells mutant for TOP3, the gene encoding the evolutionary conserved type I‐5′ topoisomerase, display a wide range of… Expand
Highly Cited
1999
Highly Cited
1999
Topoisomerases catalyse changes in the topological state of DNA and are required for many aspects of DNA metabolism. While the… Expand
  • table 1
  • figure 1
  • figure 2
  • table 2
  • figure 3
Highly Cited
1996
Highly Cited
1996
A human cDNA encoding a protein homologous to the Escherichia coli DNA topoisomerase I subfamily of enzymes has been identified… Expand
Highly Cited
1994
Highly Cited
1994
We have previously shown that cells mutant for TOP3, a gene encoding a prokaryotic-like type I topoisomerase in Saccharomyces… Expand
Highly Cited
1989
Highly Cited
1989
A hyper-recombination mutation was isolated that causes an increase in recombination between short repeated delta sequences… Expand