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TOP3A wt Allele

Known as: TOP3, Topoisomerase (DNA) III Alpha wt Allele 
Human TOP3A wild-type allele is located within 17p12-p11.2 and is approximately 41 kb in length. This allele, which encodes DNA topoisomerase 3-alpha… Expand
National Institutes of Health

Papers overview

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Highly Cited
2009
Highly Cited
2009
DNA post-replication repair (PRR) functions to bypass replication-blocking lesions and prevent damage-induced cell death. PRR… Expand
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Highly Cited
2007
Highly Cited
2007
Hypoxia is a common feature of solid tumors and is associated with their malignant phenotype. The transcription factor hypoxia… Expand
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Highly Cited
2007
Highly Cited
2007
Human solid tumors contain hypoxic regions that have considerably lower oxygen tension than the normal tissues. Hypoxia offers… Expand
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Highly Cited
2005
Highly Cited
2005
Solid tumors containing more hypoxic regions show a more malignant phenotype by increasing the expression of genes encoding… Expand
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2004
2004
Tumor hypoxia in a solid tumor mass has long been recognized as a cause of resistance to current cancer therapies, and has also… Expand
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2004
2004
In Schizosaccharomyces pombe, topoisomerase III is encoded by a single gene, top3+, which is essential for cell viability and… Expand
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Highly Cited
2003
Highly Cited
2003
Three different schemes of topography-based runoff production [versatile integrator of surface atmospheric processes (VISA)-TOP1… Expand
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Highly Cited
2002
Highly Cited
2002
The Saccharomyces cerevisiae TOP3 gene encodes the type IA topoisomerase (Top3p) that is highly conserved in evolution. Deletion… Expand
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2002
2002
A mutant allele of SGS1 of Saccharomyces cerevisiae was identified as a suppressor of the slow-growth phenotype of top3 mutants… Expand
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Highly Cited
2001
Highly Cited
2001
ABSTRACT Deletion of the Saccharomyces cerevisiae TOP3gene, encoding Top3p, leads to a slow-growth phenotype characterized by an… Expand
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