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DNA topoisomerase III alpha

Known as: TOP3alpha, TOPO IIIalpha, topoisomerase IIIalpha 
 
National Institutes of Health

Related topics

Related topics

3 relations

Broader (1)

DNA topoisomerase III
TOP3A gene

Narrower (1)

TOP3A protein, human

Papers overview

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2010
2010
Drosophila topo IIIalpha is required for the maintenance of mitochondrial genome and male germ-line stem cells.
Topoisomerase IIIalpha (topo IIIalpha), a member of the conserved Type IA subfamily of topoisomerases, is required for the cell… Expand
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Highly Cited
2008
Highly Cited
2008
Adaptation of endoplasmic reticulum exit sites to acute and chronic increases in cargo load.
The biogenesis of endoplasmic reticulum (ER) exit sites (ERES) involves the formation of phosphatidylinositol-4 phosphate (PI4… Expand
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2006
2006
Sgs1 regulates gene conversion tract lengths and crossovers independently of its helicase activity.
RecQ helicases maintain genome stability and suppress tumors in higher eukaryotes through roles in replication and DNA repair… Expand
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2006
2006
Bloom helicase and DNA topoisomerase IIIalpha are involved in the dissolution of sister chromatids.
Bloom's syndrome (BS) is an autosomal disorder characterized by predisposition to a wide variety of cancers. The gene product… Expand
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Highly Cited
2006
Highly Cited
2006
BLAP75/RMI1 promotes the BLM-dependent dissolution of homologous recombination intermediates.
BLM encodes a member of the highly conserved RecQ DNA helicase family, which is essential for the maintenance of genome stability… Expand
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Highly Cited
2005
Highly Cited
2005
Lifelong elimination of hyperbilirubinemia in the Gunn rat with a single injection of helper-dependent adenoviral vector.
Crigler-Najjar syndrome is a recessively inherited disorder characterized by severe unconjugated hyperbilirubinemia caused by a… Expand
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2005
2005
Drosophila melanogaster topoisomerase IIIalpha preferentially relaxes a positively or negatively supercoiled bubble substrate and is essential during development.
Eukaryotic type IA topoisomerases are important for the normal function of the cell, and in some cases essential for the organism… Expand
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2005
2005
Phosphorylation of BLM, dissociation from topoisomerase IIIalpha, and colocalization with gamma-H2AX after topoisomerase I-induced replication damage.
Topoisomerase I-associated DNA single-strand breaks selectively trapped by camptothecins are lethal after being converted to… Expand
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Highly Cited
2000
Highly Cited
2000
The Bloom's syndrome gene product interacts with topoisomerase III.
Bloom's syndrome is a rare genetic disorder associated with loss of genomic integrity and a large increase in the incidence of… Expand
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1999
1999
Purification and characterization of human DNA topoisomerase IIIalpha.
Human topoisomerase IIIalpha (hTopo IIIalpha), the recently identified first member of the topoisomerase IA subfamily in humans… Expand
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