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TOP1 protein, human

Known as: EC 5.99.1.2, Topo I, DNA Topoisomerase I 
DNA topoisomerase I (765 aa, ~91 kDa) is encoded by the human TOP1 gene. This protein plays a role in the regulation of DNA topology.
National Institutes of Health

Related topics

Related topics

20 relations
9-aminocamptothecinCaspase Cascade PathwayCell NucleusDB-67

Broader (1)

DNA Topoisomerases, Type I

Papers overview

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Highly Cited
2012
Highly Cited
2012
SUMO modification of the neuroprotective protein TDP1 facilitates chromosomal single-strand break repair
Breaking and sealing one strand of DNA is an inherent feature of chromosome metabolism to overcome torsional barriers. Failure to… 
Highly Cited
2010
Highly Cited
2010
Role for topoisomerase 1 in transcription-associated mutagenesis in yeast
High levels of transcription in Saccharomyces cerevisiae are associated with increased genetic instability, which has been linked… 
Highly Cited
2009
Highly Cited
2009
Selective Oxidation of DNA Topoisomerase 1 Induces Systemic Sclerosis in the Mouse1
Systemic sclerosis (SSc) is a connective tissue disorder of great clinical heterogeneity. Its pathophysiology remains unclear… 
Highly Cited
2007
Highly Cited
2007
TDP1 facilitates repair of ionizing radiation-induced DNA single-strand breaks.
Highly Cited
2005
Highly Cited
2005
Defective DNA single-strand break repair in spinocerebellar ataxia with axonal neuropathy-1
Spinocerebellar ataxia with axonal neuropathy-1 (SCAN1) is a neurodegenerative disease that results from mutation of tyrosyl… 
Highly Cited
2004
Highly Cited
2004
ABCG2 Mediates Differential Resistance to SN-38 (7-Ethyl-10-hydroxycamptothecin) and Homocamptothecins
One activity potentially limiting the efficacy of camptothecin anticancer agents is their cellular efflux by the ATP-binding… 
Highly Cited
1997
Highly Cited
1997
Effect of prolonged topotecan infusion on topoisomerase 1 levels: a phase I and pharmacodynamic study.
Topoisomerase 1 (topo-1) inhibitors act on the target enzyme by forming "cleavable complex," a high molecular weight DNA protein… 
Highly Cited
1996
Highly Cited
1996
Identification and properties of a major plasma metabolite of irinotecan (CPT-11) isolated from the plasma of patients.
Irinotecan [7-ethyl-10-[4-(1-piperidino)-1-piperidino]carbonyloxycamptothecin (CPT-11)] is a promising water-soluble analogue of… 
Highly Cited
1994
Highly Cited
1994
Apoptosis or necrosis: intracellular levels of glutathione influence mode of cell death.
Highly Cited
1990
Highly Cited
1990
HPR1, a novel yeast gene that prevents intrachromosomal excision recombination, shows carboxy-terminal homology to the Saccharomyces cerevisiae TOP1 gene
The HPR1 gene has been cloned by complementation of the hyperrecombination phenotype of hpr1-1 strains by using a color assay… 
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