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9-aminocamptothecin

Known as: Aminocamptothecin, 9-amino-20(S)-camptothecin, 9-AC 
A water-insoluble camptothecin derivative. Aminocamptothecin binds to the nuclear enzyme topoisomerase I, thereby inhibiting repair of single-strand… Expand
National Institutes of Health

Related topics

Related topics

8 relations

Broader (2)

Antineoplastic AgentsCamptothecin
DNA Replication InhibitionDNA Strand BreakNCIt Antineoplastic Agent TerminologyTOP1 protein, human
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Narrower (1)

NSC 603071

Papers overview

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Highly Cited
1999
Highly Cited
1999
Camptothecin resistance: role of the ATP-binding cassette (ABC), mitoxantrone-resistance half-transporter (MXR), and potential for glucuronidation in MXR-expressing cells.
The mitoxantrone resistance (MXR) gene encodes a recently characterized ATP-binding cassette half-transporter that confers… Expand
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Highly Cited
1999
Highly Cited
1999
Caspase-dependent Activation of Calpain during Drug-induced Apoptosis*
We have previously demonstrated that calpain is responsible for the cleavage of Bax, a proapoptotic protein, during drug-induced… Expand
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Highly Cited
1996
Highly Cited
1996
Biochemical and Biophysical Analyses of Recombinant Forms of Human Topoisomerase I (*)
Amino acid sequence comparisons of human topoisomerase I (Topo I) with seven other cellular Topo I enzymes reveal that the enzyme… Expand
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Highly Cited
1996
Highly Cited
1996
Drug-induced apoptosis in B-cell chronic lymphocytic leukemia: relationship between p53 gene mutation and bcl-2/bax proteins in drug resistance.
We investigated the relationship among chemosensitivity to drug-induced apoptosis in vitro, the presence of p53 gene mutations… Expand
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Highly Cited
1994
Highly Cited
1994
Comparison of topoisomerase I inhibition, DNA damage, and cytotoxicity of camptothecin derivatives presently in clinical trials.
BACKGROUND Camptothecins belong to a group of anticancer agents with a unique mechanism of action: poisoning of eukaryotic DNA… Expand
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Highly Cited
1992
Highly Cited
1992
Stretch‐activated anion currents of rabbit cardiac myocytes.
1. Stretch‐activated anion currents were studied in sino‐atrial and atrial cells using the whole‐cell patch clamp technique. With… Expand
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Highly Cited
1991
Highly Cited
1991
Camptothecin overcomes MDR1-mediated resistance in human KB carcinoma cells.
In order to understand the high efficacy of camptothecin derivatives against human colon tumor xenografts in nude mice, we have… Expand
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Highly Cited
1989
Highly Cited
1989
DNA topoisomerase I--targeted chemotherapy of human colon cancer in xenografts.
Drug development is needed to improve chemotherapy of patients with locally advanced or metastatic colon carcinoma, who otherwise… Expand
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Highly Cited
1980
Highly Cited
1980
Calcium-induced exposure of a hydrophobic surface on calmodulin.
Interactions between calmodulin (CaM) and several hydrophobic fluorescent probes were characterized in order to determine if CaM… Expand
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Highly Cited
1977
Highly Cited
1977
On the inhibition of muscle membrane chloride conductance by aromatic carboxylic acids
25 aromatic carboxylic acids which are analogs of benzoic acid were tested in the rat diaphragm preparation for effects on… Expand
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