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9-aminocamptothecin

Known as: Aminocamptothecin, 9-amino-20(S)-camptothecin, 9-AC 
A water-insoluble camptothecin derivative. Aminocamptothecin binds to the nuclear enzyme topoisomerase I, thereby inhibiting repair of single-strand… 
National Institutes of Health

Papers overview

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Highly Cited
1999
Highly Cited
1999
The mitoxantrone resistance (MXR) gene encodes a recently characterized ATP-binding cassette half-transporter that confers… 
Highly Cited
1999
Highly Cited
1999
We have previously demonstrated that calpain is responsible for the cleavage of Bax, a proapoptotic protein, during drug-induced… 
Review
1998
Review
1998
Highly Cited
1996
Highly Cited
1996
We investigated the relationship among chemosensitivity to drug-induced apoptosis in vitro, the presence of p53 gene mutations… 
Highly Cited
1994
Highly Cited
1994
BACKGROUND Camptothecins belong to a group of anticancer agents with a unique mechanism of action: poisoning of eukaryotic DNA… 
Highly Cited
1992
Highly Cited
1992
1. Stretch‐activated anion currents were studied in sino‐atrial and atrial cells using the whole‐cell patch clamp technique. With… 
Highly Cited
1991
Highly Cited
1991
In order to understand the high efficacy of camptothecin derivatives against human colon tumor xenografts in nude mice, we have… 
Highly Cited
1989
Highly Cited
1989
Drug development is needed to improve chemotherapy of patients with locally advanced or metastatic colon carcinoma, who otherwise… 
Highly Cited
1980
Highly Cited
1980
Interactions between calmodulin (CaM) and several hydrophobic fluorescent probes were characterized in order to determine if CaM… 
Highly Cited
1977
Highly Cited
1977
25 aromatic carboxylic acids which are analogs of benzoic acid were tested in the rat diaphragm preparation for effects on…