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9-aminocamptothecin
Known as:
Aminocamptothecin
, 9-amino-20(S)-camptothecin
, 9-AC
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A water-insoluble camptothecin derivative. Aminocamptothecin binds to the nuclear enzyme topoisomerase I, thereby inhibiting repair of single-strand…
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National Institutes of Health
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Related topics
Related topics
8 relations
Broader (2)
Antineoplastic Agents
Camptothecin
DNA Replication Inhibition
DNA Strand Break
NCIt Antineoplastic Agent Terminology
TOP1 protein, human
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Narrower (1)
NSC 603071
Papers overview
Semantic Scholar uses AI to extract papers important to this topic.
2002
2002
Multicentre phase II and pharmacokinetic study of RFS2000 (9-nitro-camptothecin) administered orally 5 days a week in patients with glioblastoma multiforme.
E. Raymond
,
M. Campone
,
+7 authors
P. Fumoleau
European Journal of Cancer
2002
Corpus ID: 10457891
2001
2001
Relation between 9-aminocamptothecin systemic exposure and tumor response in human solid tumor xenografts.
M. Kirstein
,
P. Houghton
,
+4 authors
C. Stewart
Clinical Cancer Research
2001
Corpus ID: 22550076
9-Aminocamptothecin (9-AC) is a topoisomerase I inhibitor with activity against xenografts from childhood solid tumors; however…
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2001
2001
Why drugs fail: of mice and men revisited.
C. Takimoto
Clinical Cancer Research
2001
Corpus ID: 32725988
Of the large number of promising anticancer agents entering into clinical testing, only a disappointingly small number ultimately…
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1998
1998
Microsomal metabolism of carbamazepine and oxcarbazepine in liver and placenta
P. Myllynen
,
P. Pienimäki
,
H. Raunio
,
K. Vähäkangas
Human and Experimental Toxicology
1998
Corpus ID: 24778655
Metabolism of both carbamazepine (CBZ) and oxcarbaze-pine (OCBZ) were catalyzed by human liver microsomes and microsomes from…
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Highly Cited
1997
Highly Cited
1997
Ca2+ current and Ca2+ ‐activated chloride current in isolated smooth muscle cells of the sheep urethra
K. Cotton
,
M. Hollywood
,
N. Mchale
,
K. Thornbury
Journal of Physiology
1997
Corpus ID: 27109968
1 Isolated sheep urethral cells were studied using the perforated patch clamp technique (T= 37 °C). Depolarizing steps ranging…
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1997
1997
Potentiation of murine MCa-4 carcinoma radioresponse by 9-amino-20(S)-camptothecin.
A. Kirichenko
,
T. Rich
,
R. Newman
,
E. Travis
Cancer Research
1997
Corpus ID: 39843201
9-Amino-20(S)-camptothecin (9-AC) has demonstrated efficacy against several human cancer xenografts, including cancers of the…
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Highly Cited
1996
Highly Cited
1996
Association of ClC-3 Channel with Cl− Transport by Human Nonpigmented Ciliary Epithelial Cells
Miguel Coca-Prados
,
J. Sánchez-Torres
,
K. Peterson‐Yantorno
,
M. Civan
Journal of Membrane Biology
1996
Corpus ID: 10331960
Abstract. Electrophysiologic and volumetric evidence link the swelling-activated Cl− channels [gCl(Vol)] of nonpigmented ciliary…
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1996
1996
Potentiation of cisplatin cytotoxicity by 9-aminocamptothecin.
F. Goldwasser
,
M. Valenti
,
R. Torres
,
K. Kohn
,
Y. Pommier
Clinical Cancer Research
1996
Corpus ID: 35024107
Camptothecin (CPT) derivatives are presently in ongoing Phase I/II clinical trials. The interactions between 9-aminocamptothecin…
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1996
1996
A Bicarbonate- and Weak Acid-permeable Chloride Conductance Controlled by Cytosolic Ca2+ and ATP in Rat Submandibular Acinar Cells
T. Ishikawa
Journal of Membrane Biology
1996
Corpus ID: 26425208
Abstract. A Ca2+-activated Cl− conductance in rat submandibular acinar cells was identified and characterized using whole-cell…
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Highly Cited
1993
Highly Cited
1993
Camptothecin derivatives induce regression of human ovarian carcinomas grown in nude mice and distinguish between non‐tumorigenic and tumorigenic cells in vitro
P. Pantazis
,
A. Kozielski
,
J. Mendoza
,
J. Early
,
H. Hinz
,
B. Giovanella
International Journal of Cancer
1993
Corpus ID: 22017567
We have recently shown that the plant alkaloid 20(S)‐camptothecin and its derivatives 9‐nitro‐20(S)‐camptothecin(9NC) and 9‐amino…
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