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9-aminocamptothecin

Known as: Aminocamptothecin, 9-amino-20(S)-camptothecin, 9-AC 
A water-insoluble camptothecin derivative. Aminocamptothecin binds to the nuclear enzyme topoisomerase I, thereby inhibiting repair of single-strand… 
National Institutes of Health

Related topics

Related topics

8 relations

Broader (2)

Antineoplastic AgentsCamptothecin
DNA Replication InhibitionDNA Strand BreakNCIt Antineoplastic Agent TerminologyTOP1 protein, human

Narrower (1)

NSC 603071

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2002
2002
Multicentre phase II and pharmacokinetic study of RFS2000 (9-nitro-camptothecin) administered orally 5 days a week in patients with glioblastoma multiforme.
2001
2001
Relation between 9-aminocamptothecin systemic exposure and tumor response in human solid tumor xenografts.
9-Aminocamptothecin (9-AC) is a topoisomerase I inhibitor with activity against xenografts from childhood solid tumors; however… 
2001
2001
Why drugs fail: of mice and men revisited.
Of the large number of promising anticancer agents entering into clinical testing, only a disappointingly small number ultimately… 
1998
1998
Microsomal metabolism of carbamazepine and oxcarbazepine in liver and placenta
Metabolism of both carbamazepine (CBZ) and oxcarbaze-pine (OCBZ) were catalyzed by human liver microsomes and microsomes from… 
Highly Cited
1997
Highly Cited
1997
Ca2+ current and Ca2+ ‐activated chloride current in isolated smooth muscle cells of the sheep urethra
1 Isolated sheep urethral cells were studied using the perforated patch clamp technique (T= 37 °C). Depolarizing steps ranging… 
1997
1997
Potentiation of murine MCa-4 carcinoma radioresponse by 9-amino-20(S)-camptothecin.
9-Amino-20(S)-camptothecin (9-AC) has demonstrated efficacy against several human cancer xenografts, including cancers of the… 
Highly Cited
1996
Highly Cited
1996
Association of ClC-3 Channel with Cl− Transport by Human Nonpigmented Ciliary Epithelial Cells
Abstract. Electrophysiologic and volumetric evidence link the swelling-activated Cl− channels [gCl(Vol)] of nonpigmented ciliary… 
1996
1996
Potentiation of cisplatin cytotoxicity by 9-aminocamptothecin.
Camptothecin (CPT) derivatives are presently in ongoing Phase I/II clinical trials. The interactions between 9-aminocamptothecin… 
1996
1996
A Bicarbonate- and Weak Acid-permeable Chloride Conductance Controlled by Cytosolic Ca2+ and ATP in Rat Submandibular Acinar Cells
Abstract. A Ca2+-activated Cl− conductance in rat submandibular acinar cells was identified and characterized using whole-cell… 
Highly Cited
1993
Highly Cited
1993
Camptothecin derivatives induce regression of human ovarian carcinomas grown in nude mice and distinguish between non‐tumorigenic and tumorigenic cells in vitro
We have recently shown that the plant alkaloid 20(S)‐camptothecin and its derivatives 9‐nitro‐20(S)‐camptothecin(9NC) and 9‐amino… 
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