Skip to search formSkip to main contentSkip to account menu

9-aminocamptothecin

Known as: Aminocamptothecin, 9-amino-20(S)-camptothecin, 9-AC 
A water-insoluble camptothecin derivative. Aminocamptothecin binds to the nuclear enzyme topoisomerase I, thereby inhibiting repair of single-strand… 
National Institutes of Health

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2001
2001
9-Aminocamptothecin (9-AC) is a topoisomerase I inhibitor with activity against xenografts from childhood solid tumors; however… 
2001
2001
Of the large number of promising anticancer agents entering into clinical testing, only a disappointingly small number ultimately… 
1998
1998
Metabolism of both carbamazepine (CBZ) and oxcarbaze-pine (OCBZ) were catalyzed by human liver microsomes and microsomes from… 
Highly Cited
1997
Highly Cited
1997
1 Isolated sheep urethral cells were studied using the perforated patch clamp technique (T= 37 °C). Depolarizing steps ranging… 
1997
1997
9-Amino-20(S)-camptothecin (9-AC) has demonstrated efficacy against several human cancer xenografts, including cancers of the… 
Highly Cited
1996
Highly Cited
1996
Abstract. Electrophysiologic and volumetric evidence link the swelling-activated Cl− channels [gCl(Vol)] of nonpigmented ciliary… 
1996
1996
Camptothecin (CPT) derivatives are presently in ongoing Phase I/II clinical trials. The interactions between 9-aminocamptothecin… 
1996
1996
Abstract. A Ca2+-activated Cl− conductance in rat submandibular acinar cells was identified and characterized using whole-cell… 
Highly Cited
1993
Highly Cited
1993
We have recently shown that the plant alkaloid 20(S)‐camptothecin and its derivatives 9‐nitro‐20(S)‐camptothecin(9NC) and 9‐amino…