9-aminocamptothecin

Known as: Aminocamptothecin, 9-amino-20(S)-camptothecin, 9-AC 
A water-insoluble camptothecin derivative. Aminocamptothecin binds to the nuclear enzyme topoisomerase I, thereby inhibiting repair of single-strand… (More)
National Institutes of Health

Related topics

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7 relations

Broader (2)

Antineoplastic AgentsCamptothecin
DNA Replication InhibitionDNA Strand BreakTOP1 protein, humananalogs & derivatives

Narrower (1)

NSC 603071

Papers overview

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2001
2001
Relation between 9-aminocamptothecin systemic exposure and tumor response in human solid tumor xenografts.
9-Aminocamptothecin (9-AC) is a topoisomerase I inhibitor with activity against xenografts from childhood solid tumors; however… (More)
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Review
2000
Review
2000
The clinical development of 9-aminocamptothecin.
9-Aminocamptothecin (9-AC) is a topoisomerase I-targeting agent first synthesized by Wani and Wall in 1986. Because of its potent… (More)
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Highly Cited
1999
Highly Cited
1999
Advances in Brief Overexpression of the BCRP / MXR / ABCP Gene in a Topotecan-selected Ovarian Tumor Cell Line 1
Topotecanor mitoxantrone-selected cell lines (T8 and MX3, respectively), derived from the human IGROV1 ovarian cancer cell line… (More)
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Highly Cited
1999
Highly Cited
1999
Caspase-dependent activation of calpain during drug-induced apoptosis.
We have previously demonstrated that calpain is responsible for the cleavage of Bax, a proapoptotic protein, during drug-induced… (More)
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1998
1998
Increased 9-aminocamptothecin dose requirements in patients on anticonvulsants
Background: High grade astrocytomas remain uniformly fatal despite aggressive surgery and radiotherapy. As existing… (More)
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Highly Cited
1997
Highly Cited
1997
Differential toxicity of camptothecin, topotecan and 9-aminocamptothecin to human, canine, and murine myeloid progenitors (CFU-GM) in vitro
 Purpose: 20(S)-Camptothecin (CAM), topotecan (TPT, active ingredient in Hycamtin) and 9-amino-20(S)-camptothecin (9AC) are… (More)
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Highly Cited
1996
Highly Cited
1996
Drug-induced apoptosis in B-cell chronic lymphocytic leukemia: relationship between p53 gene mutation and bcl-2/bax proteins in drug resistance.
We investigated the relationship among chemosensitivity to drug-induced apoptosis in vitro, the presence of p53 gene mutations… (More)
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1996
1996
Potentiation of cisplatin cytotoxicity by 9-aminocamptothecin.
Camptothecin (CPT) derivatives are presently in ongoing Phase I/II clinical trials. The interactions between 9-aminocamptothecin… (More)
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1995
1995
A phase I and pharmacokinetic study of a new camptothecin derivative, 9-aminocamptothecin.
Camptothecins are the only available antitumor agents which target the nuclear enzyme topoisomerase I. 9-Aminocamptothecin (9-AC… (More)
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Highly Cited
1992
Highly Cited
1992
Stretch-activated anion currents of rabbit cardiac myocytes.
1. Stretch-activated anion currents were studied in sino-atrial and atrial cells using the whole-cell patch clamp technique. With… (More)
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