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DB-67

Known as: DB 67, Silatecan AR-67, AR-67 
A synthetic, highly lipophilic derivative of camptothecin, with potential antineoplastic and radiosensitizing activities. 7-tert-butyldimethylsilyl… 
National Institutes of Health

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Broader (1)

7-tert-butyldimethylsilyl-10-hydroxycamptothecin
DNA Replication InhibitionDNA Strand BreakTOP1 protein, human

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2014
2014
Protracted dosing of the lipophilic camptothecin analogue AR-67 in non-small cell lung cancer xenografts and humans
AbstractPurpose Although preclinical studies on camptothecin antitumor effect have demonstrated the superiority of low-dose… 
2013
2013
The Effect of Breast Cancer Resistance Protein, Multidrug Resistant Protein 1, and Organic Anion-Transporting Polypeptide 1B3 on the Antitumor Efficacy of the Lipophilic Camptothecin 7-t…
AR-67 (7-t-butyldimethylsilyl-10-hydroxycamptothecin) is a lipophilic camptothecin analog, currently under early stage clinical… 
2010
2010
A Phase I Study of 7-t-Butyldimethylsilyl-10-Hydroxycamptothecin in Adult Patients with Refractory or Metastatic Solid Malignancies
Purpose: 7-t-Butyldimethylsilyl-10-hydroxycamptothecin (AR-67) is a novel third generation camptothecin selected for development… 
2010
2010
Incorporation of ionic ligands accelerates drug release from LDI-glycerol polyurethanes.
2010
2010
Factors Affecting the In Vivo Lactone Stability and Systemic Clearance of the Lipophilic Camptothecin Analogue AR-67
ABSTRACTPurposeThe narrow efficacy-toxicity window of anticancer agents necessitates understanding of factors contributing to… 
2009
2009
Metabolism and transport pathways of the blood stable camptothecin AR-67 (7-t-butyldimethylsilyl-10-hydroxycamptothecin).
2553 Background: AR-67 is a 3rd generation camptothecin analog with superior stability of its active lactone form (>85%). This… 
2007
2007
Determination of hydroxycamptothecin affinities to albumin and membranes by steady-state fluorescence anisotropy measurements.
Camptothecin (CPT) and its hydroxycamptothecin analogs are fluorescent compounds exhibiting strong anticancer properties. They… 
2004
2004
The effect of DB-67, a lipophilic camptothecin derivative, on topoisomerase I levels in non-small-cell lung cancer cells
PurposeTo determine the in vitro drug sensitivity of two non-small-cell lung cancer cell lines after treatment with the novel… 
2002
2002
Stable Supersaturated Aqueous Solutions of Silatecan 7-t-Butyldimethylsilyl-10-Hydroxycamptothecin via Chemical Conversion in the Presence of a Chemically Modified β-Cyclodextrin
AbstractPurpose. A method for obtaining clear supersaturated aqueous solutions for parenteral administration of the poorly… 
Highly Cited
2001
Highly Cited
2001
The highly lipophilic DNA topoisomerase I inhibitor DB-67 displays elevated lactone levels in human blood and potent anticancer activity.
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