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DB-67

Known as: DB 67, Silatecan AR-67, AR-67 
A synthetic, highly lipophilic derivative of camptothecin, with potential antineoplastic and radiosensitizing activities. 7-tert-butyldimethylsilyl… 
National Institutes of Health

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Broader (1)

7-tert-butyldimethylsilyl-10-hydroxycamptothecin
DNA Replication InhibitionDNA Strand BreakTOP1 protein, human

Papers overview

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2014
2014
Protracted dosing of the lipophilic camptothecin analogue AR-67 in non-small cell lung cancer xenografts and humans
AbstractPurpose Although preclinical studies on camptothecin antitumor effect have demonstrated the superiority of low-dose… 
2010
2010
A Phase I Study of 7-t-Butyldimethylsilyl-10-Hydroxycamptothecin in Adult Patients with Refractory or Metastatic Solid Malignancies
Purpose: 7-t-Butyldimethylsilyl-10-hydroxycamptothecin (AR-67) is a novel third generation camptothecin selected for development… 
2010
2010
Incorporation of ionic ligands accelerates drug release from LDI-glycerol polyurethanes.
2010
2010
Factors Affecting the In Vivo Lactone Stability and Systemic Clearance of the Lipophilic Camptothecin Analogue AR-67
ABSTRACTPurposeThe narrow efficacy-toxicity window of anticancer agents necessitates understanding of factors contributing to… 
2009
2009
Metabolism and transport pathways of the blood stable camptothecin AR-67 (7-t-butyldimethylsilyl-10-hydroxycamptothecin).
2553 Background: AR-67 is a 3rd generation camptothecin analog with superior stability of its active lactone form (>85%). This… 
2005
2005
Silatecan DB-67 is a novel DNA topoisomerase I-targeted radiation sensitizer.
The silatecan 7-tert-butyldimethylsilyl-10-hydroxy-camptothecin (DB-67) represents a new generation of camptothecin derivatives… 
2004
2004
The effect of DB-67, a lipophilic camptothecin derivative, on topoisomerase I levels in non-small-cell lung cancer cells
PurposeTo determine the in vitro drug sensitivity of two non-small-cell lung cancer cell lines after treatment with the novel… 
2002
2002
Stable Supersaturated Aqueous Solutions of Silatecan 7-t-Butyldimethylsilyl-10-Hydroxycamptothecin via Chemical Conversion in the Presence of a Chemically Modified β-Cyclodextrin
AbstractPurpose. A method for obtaining clear supersaturated aqueous solutions for parenteral administration of the poorly… 
2002
2002
A versatile prodrug approach for liposomal core-loading of water-insoluble camptothecin anticancer drugs.
We describe a versatile prodrug strategy for loading the liposomal lumen with water-insoluble camptothecins. The procedure… 
Highly Cited
2001
Highly Cited
2001
The highly lipophilic DNA topoisomerase I inhibitor DB-67 displays elevated lactone levels in human blood and potent anticancer activity.
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